Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:2.7.11.22 (
cdc2
)
8,319
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Long noncoding RNAs (lncRNAs) are usually associated with tumor development and progression and some of them are dysregulated in various human cancers. The mechanisms underlying their dysregulation are worth further study. Here, we demonstrate that the expression level of LNC
CRYBG3
is correlated with 1501 aberrantly expressed proteins in A549 cells (non-small cell lung cancer (NSCLC) cells). LNC
CRYBG3
overexpression results in M phase arrest and promoted cell death, whereas LNC
CRYBG3
knockdown did not elicit the opposite effects. The overexpression of LNC
CRYBG3
inhibits cell proliferation both
in vitro
and in vivo. Moreover, it upregulates the expression of cyclin B1 and the phosphorylation of H3, whereas it inhibited the expression of
cyclin-dependent kinase 6
and cyclin D1. Taken together, these findings suggest that LNC
CRYBG3
regulates the cell cycle process of A549 cells, suggesting its potential application for the treatment of this disease.
...
PMID:LNC CRYBG3 inhibits tumor growth by inducing M phase arrest. 3125 84
