Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:2.7.11.22 (
cdc2
)
8,319
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Cyclin A is indispensable for S phase cell cycle progression and is suggested to be a crucial target of cell adhesion signals. In this study, we demonstrate that
beta3-endonexin
, a molecule known to associate with the integrin beta3 cytoplasmic domain, specifically binds cyclin A. Deletion of the amino-terminal 52-amino-acid residues including the cyclin-binding RxL motif abolishes the ability of
beta3-endonexin
to interact with cyclin A. In an in vitro kinase assay,
beta3-endonexin
inhibits pRB kinase activity associated with cyclin A-
Cdk2
while leaving its histone H1 kinase activity unaffected. Coexpression of
beta3-endonexin
in yeast cells overcomes growth suppression caused by an activation of cyclin A-associated kinase. Our results indicate that
beta3-endonexin
is a novel cyclin A-binding molecule that regulates cyclin A-associated pRB kinase activity.
...
PMID:beta3-endonexin as a novel inhibitor of cyclin A-associated kinase. 1067 97
