Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:2.7.11.22 (cdc2)
 8,319 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Cdc2 proteins are well characterized as protein kinases and are functionally involved in the control of the G2 to M transition during cell division. cdc2 proteins (cdc2Sp, CDC28 and CDC2Gg) and proteins sharing a high degree of similarity with cdc2 proteins (EG1 and DM2C), and therefore belonging to the same structural family, were analyzed using Fourier transform of the coded sequences. Characteristic code/frequency pairs (0.140, 0.148 and 0.238) distinguish the cdc2 proteins from the related proteins. The frequencies 0.140, 0.148 and 0.238 (and the associated codes) allow discrimination between all cdc2 proteins (cdc2Sp, CDC28, CDC2Gg, CDC2Hs, CDC2Mm, CDC2Dm, CDC2Ms) and related proteins (EG1, DM2C, MO15, GTA, PHO85, KSS1, PSKJ3, FUS3, KIN28), thus providing the first evidence for predicting cdc2 function from a sequence. A rice cdc2 homolog (R2) did not match the cdc2 proteins and is, therefore, unlikely to be a cdc2 protein. Pertinent patterns in the cdc2 proteins were searched, and mapped to the 90-210 region (numbering from cdc2 of S. pombe) which correlates well with the putative cyclin binding domain of the cdc2 proteins.
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PMID:Distinction by sequence analysis between cdc2 protein kinases involved in cell cycle control and closely related proteins. 181 88

The cell division cycle have been shown to be regulated by a closely-related family of protein kinases named CDKs (by cyclin-dependent kinases). Using a PCR-based cloning technique, we have isolated cDNAs encoding a human CDC2-related protein kinase. The full-length cDNA accommodates an open reading frame that does not contain any ATG initiation codon upstream of the sequence encoding the catalytic domain of this putative kinase. Three putative non-ATG initiation codons have been detected. Starting at the most 5' non-ATG initiation site, the encoded product is 316 amino acids long with a predicted molecular weight of 35.8 kDa. Analysis of the deduced amino acid sequence showed it to contain the XI subdomains present in all known protein kinases and a PSTAIRE-like motive, PISSLRE, which temporarily names this kinase. PISSLRE is most related to p58/GTA (55% identity in the catalytic domain), the galactosyl transferase associated protein, which has been shown to inhibit entry into S-phase when over-expressed in CHO cells. PISSLRE shares 38-45% identity with all CDKs and contains the regulatory Tyr and Thr residues present in most of the members of the CDK family of protein kinases, which suggests similar modes of regulation. PISSLRE is expressed in all human tissues tested, including those which contain high proportion of terminally differentiated cells. However, the levels of the PISSLRE transcripts are dissimilar among different tissues.
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PMID:PISSLRE, a human novel CDC2-related protein kinase. 820 57

Cyclin-dependent kinases (cdks) is a family of serine-threonine kinases whose principal role is the promotion of the cell transition through the regulatory points of the cell cycle (G1 and G2/M). The best known human cdks are: cdk1-cdk7 and p58-GTA. The latter one, contrarily to the other cdks, is supposed to act as a antiproliferative factor. Most cdks may be involved in the development of neoplastic disorders. This hypothesis is based on their biological features (interactions with viral oncoproteins), their hyperexpression in some malignancies and frequent deletions of cdk inhibitory genes in cancer cells. cdk5, which displays the maximal kinase activity in non-proliferating brain neurons may participate in the pathogeny of the Alzheimer's disease.
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PMID:[Cyclin dependent kinases. From molecular biology to pathology]. 865 28