Gene/Protein
Disease
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Enzyme
Compound
Pivot Concepts:
Gene/Protein
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Drug
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Target Concepts:
Gene/Protein
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Query: EC:2.7.11.22 (
cdc2
)
8,319
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The microtubule-dependent molecular motor
KIF23
(Kinesin family member 23) is one of two components of the centralspindlin complex assembled during late stages of mitosis. Formation of this complex is known as an essential step for cytokinesis. Here, we identified
KIF23
as a new transcriptional target gene of the tumor suppressor protein p53. We showed that p53 reduces expression of
KIF23
on the mRNA as well as the protein level in different cell types. Promoter reporter assays revealed that this repression results from downregulation of
KIF23
promoter activity.
CDK
inhibitor p21(WAF1/CIP1) was shown to be necessary to mediate p53-dependent repression. Furthermore, we identified the highly conserved cell cycle genes homology region (CHR) in the
KIF23
promoter to be strictly required for p53-dependent repression as well as for cell cycle-dependent expression of
KIF23
. Cell cycle- and p53-dependent regulation of
KIF23
appeared to be controlled by differential binding of DREAM and MMB complexes to the CHR element. With this study, we describe a new mechanism for transcriptional regulation of
KIF23
. Considering the strongly supporting function of
KIF23
in cytokinesis, its p53-dependent repression may contribute to the prevention of uncontrolled cell growth.
...
PMID:p53 and cell cycle dependent transcription of kinesin family member 23 (KIF23) is controlled via a CHR promoter element bound by DREAM and MMB complexes. 2365 May 52
