Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:2.7.11.22 (
cdc2
)
8,319
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The mechanisms by which cyclins promote mammalian cell cycle progression have been a topic of intense investigation over the last decade. We previously described an interaction between D-type cyclins and A-kinase anchoring protein,
AKAP95
. Here, we demonstrate that
AKAP95
can also bind cyclin E1. Association between
AKAP95
and cyclins is displaced by CDKs. We show that these G(1)/S cyclins can interact with RII subunit of PKAalpha through
AKAP95
. The presence of alternate complexes cyclin-
CDK
and cyclin D/E-
AKAP95
-PKA.RIIalpha suggest different roles of G(1)/S cyclins and a wider biological importance of these interactions in cells.
...
PMID:G1/S Cyclins interact with regulatory subunit of PKA via A-kinase anchoring protein, AKAP95. 1672 Oct 56
