Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:2.7.11.22 (
cdc2
)
8,319
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The activity of p34(
cdc2
) plays a key role in the regulation of the eukaryotic cell cycle. Another cell cycle associated molecule is PCNA. We investigated the effects of
2-hydroxy-17beta-estradiol
, a cell proliferator, and 2-methoxy-17beta-estradiol, a potent inhibitor of cell growth, on the levels and activity of p34(
cdc2
) and on the levels of PCNA, as well as on protein phosphorylation in MCF-7 cells.
2-Hydroxyestradiol
increased p34(
cdc2
) activity at G1/S and elevated PCNA levels during S-phase. 2-Methoxyestradiol caused unscheduled activation of p34(
cdc2
) in S-phase and decreased levels of p34(
cdc2
) and PCNA during G2/M. We conclude that 2-hydroxy- and 2-methoxyestradiol have definite, though different regulatory functions during the cell cycle.
...
PMID:17beta-Estradiol metabolites affect some regulators of the MCF-7 cell cycle. 901 99
