Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:2.7.11.22 (
cdc2
)
8,319
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Flubendazole
, FDA-approved anthelmintic, has been widely used in treating testinal parasites. In the recent years,
Flubendazole
has been reported to exert anticancer activities. On the other hand, little was known about the effects of
Flubendazole
on gliomas. Here we demonstrated a novel effect of flubendazole on glioma cells. We found that
Flubendazole
inhibited cell proliferation and promoted cell apoptosis of glioma cell lines in vitro, and suppressed tumor growth in xenograft models by intraperitoneal injection. However,
Flubendazole
might have no influence on cell migration. Mechanism study reaveled that
Flubendazole
caused cell cycle arrest in G2/M phase, which partly account for the suppressed proliferation. Consistently,
Flubendazole
induced P53 expression and reduced Cyclin B1 and p-
cdc2
expression in glioma cells. In addition,
Flubendazole
promoted cell apoptosis by regulating the classical apoptosis protein BCL-2 expression. These observations suggest that
Flubendazole
exerts anti-proliferation and pro-apoptosis effects in Glioma through affecting the cell cycle and intrinsic apoptotic signaling, and indicate a novel utilization of
Flubendazole
in the treatment of Glioma.
...
PMID:Flubendazole inhibits glioma proliferation by G2/M cell cycle arrest and pro-apoptosis. 2953 15
