Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:2.7.11.22 (
cdc2
)
8,319
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Some anticancer agents induce cell cycle arrest. We analyzed the effect of anticancer agents on cell-cycle regulators, such as
CDK
. Our data suggested that arresting cells in the G2-phase of the cell cycle by cisplatin might be regulated by dephosphorylation of
cdc2 kinase
. Butyrolactone I inhibits both
cdc2
and CDK2 kinase in the cell-free system. The cytotoxic effect of paclitaxel shows mainly in the M-phase of the cell cycle.
Suramin
inhibits
cdc2 kinase
. UCN-01, a protein kinase-C inhibitor, also inhibits both
cdc2
and CDK2 kinase. Some anticancer agents induce apoptosis.
...
PMID:[Cell cycle regulation by anticancer agent]. 757 1
