Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:2.7.11.22 (
cdc2
)
8,319
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The molecular mechanism underlying protein kinase C (PKC)-mediated cell cycle arrest is poorly understood. We undertook to characterize phorbol ester-activated PKC-mediated cell cycle arrest. Treatment with phorbol ester inhibited cell growth of human
histiocytic lymphoma
U937 cells with 83% of the cells arrested in G1 phase. Reduced activity of
cdk2
correlated with
cdk2
dephosphorylation and accumulation of
cdk2
inhibitor p21Waf in phorbol ester-treated cells. Dephosphorylation of
cdk2
was not associated with
cdk7
and cdc25A activity in phorbol ester-treated cells. Protein phosphatase inhibitor assays suggest that the dephosphorylation of
cdk2
results in the activation of a specific protein tyrosine phosphatase. Thus, dephosphorylation of
cdk2
as well as accumulation of
cdk2
inhibitor is likely to contribute to the G1 phase arrest in phorbol ester-treated in U937 cells.
...
PMID:Cdk7- and Cdc25A-independent dephosphorylation of Cdk2 during phorbol ester-mediated cell cycle arrest in U937 cells. 1085 62
