Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:2.7.11.22 (
cdc2
)
8,319
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The p16(INK4a) tumor suppressor inhibits cyclin-dependent kinases (CDK4 and CDK6). Here we report the isolation of a novel gene,
SEI-1
, whose product (p34(
SEI-1
)) appears to antagonize the function of p16(INK4a). Addition of p34(
SEI-1
) to cyclin D1-CDK4 renders the complex resistant to inhibition by p16(INK4a). Expression of
SEI-1
is rapidly induced on addition of serum to quiescent fibroblasts, and ectopic expression of p34(
SEI-1
) enables fibroblasts to proliferate even in low serum concentrations. p34(
SEI-1
) seems to act as a growth factor sensor and may facilitate the formation and activation of cyclin D-
CDK
complexes in the face of inhibitory levels of INK4 proteins.
...
PMID:Regulation of CDK4 activity by a novel CDK4-binding protein, p34(SEI-1). 1058 9
