Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts: Gene/Protein Disease Symptom Drug Enzyme Compound   Target Concepts: Gene/Protein Disease Symptom Drug Enzyme Compound

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Query: EC:2.7.11.2 (PDK1)
2,238 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .

Human Gene/Protein PDK1 980 pyruvate dehydrogenase kinase 637 PDK 528 pyruvate dehydrogenase 348 insulin 327 PDK4 300 PI3K 256 AKT 223 Mol 220 mTOR 210 ATP 208 pyruvate dehydrogenase complex 201 Sep 143 PDK2 129 PKB 105 phosphatase 101 PTEN 95 protein kinase B 87 PDH 86 phosphatidylinositol 3-kinase 85 PKC 72 ERK 66 MAPK 64 threonine 64 ERK1 59 phosphoinositide 3-kinase 58 S6K1 55 p53 49 peroxisome proliferator-activated receptor 48 glucose transporter 48 PGC 47 Bcl-2 47 ADP 46 caspase-3 45 Pyruvate dehydrogenase 42 phosphorylating 41 MEK 40 PDK3 40 p38 38 insulin receptor 38 NADH 37 SGK1 36 AMPK 35 IRS-1 35 lactate dehydrogenase 34 pleckstrin 33 ROS 33 PDK4 protein 33 cyclin D1 33 PI3 32 GSK 32 vascular endothelial growth factor 31 JNK 30 PKA 30 lactate dehydrogenase A 29 PH domain 28 rhabdomyosarcoma 28 TCA 28 AMP-activated protein kinase 27 tyrosine kinase 27 LDHA 26 p21 26 p70 26 GLUT1 26 GLUT4 26 catenin 25 VEGF 24 NAD 24 MEK1 23 AMP 23 UCP3 22 peroxisome proliferator-activated receptor gamma 22 serine/threonine kinase 22 cytokine 22 SGK 22 insulin-like growth factor 21 PPAR 21 p85 21 p27 21 pyruvate dehydrogenase kinase 4 21 more...

Disease cancer 490 tumor 267 diabetes 127 breast cancer 75 obesity 70 tumor growth 68 tumorigenesis 67 type 2 diabetes 47 carcinoma 42 ischemia 41 hepatocellular carcinoma 39 tumor progression 37 colorectal cancer 35 lung cancer 33 heart failure 31 prostate cancer 30 hyperglycemia 28 glioblastoma 28 carcinogenesis 25 colon cancer 25 adenocarcinoma 24 glioma 23 hypertension 23 leukemia 22 non-small cell lung cancer 22 gastric cancer 21 sepsis 20 sepsis 20 stroke 19 MCF 19 Alzheimer's disease 19 dengue 17 pancreatic cancer 17 metastases 15 acute myeloid leukemia 15 neuroblastoma 15 ovarian cancer 14 lactic acidosis 13 hyperinsulinemia 13 squamous cell carcinoma 13 metabolic syndrome 12 lymphoma 11 cardiovascular disease 11 cold 11 tuberous sclerosis 11 melanoma 11 PDC 11 myocardial infarction 11 depression 11 hyperthyroidism 11 glucose intolerance 11 cervical cancer 10 glioblastoma multiforme 10 FAS 10 PDP 9 Parkinson's disease 9 atherosclerosis 8 brain tumor 8 Blocking 8 renal cell carcinoma 8 GSH 8 fatty liver 8 cerebral ischemia 8 plaque 8 amyotrophic lateral sclerosis 7 osteosarcoma 7 sickle cell disease 7 vascular disease 7 hyperlipidemia 7 peripheral neuropathy 7 hypoglycemia 7 lung carcinoma 7 liver cancer 7 aggressiveness 7 Hippel 7 dyslipidemia 6 ATM 6 SDS 6 liver cancer 6 SCD 6 more...

Symptom starvation 70 exhaustion 8 fatigue 6 pain 6 weakness 5 acidity 5 cachexia 5 seizures 4 hypothermia 3 overweight 3 hunger 2 ataxia 2 anesthesia 2 tremor 2 collapse 2 anorexia 2 eye pain 1 polyuria 1 functional recovery 1 skin damage 1 numbness 1 memory loss 1 Ill 1 hyperoxia 1 neurological disability 1 headache 1 ophthalmoplegia 1 acute stress 1 dry eye 1 decreased appetite 1 HSA 1 flushing 1 sore throat 1 myalgia 1 pelvic pain 1

Drug NADH 36 ROS 33 lysine 19 citric acid 11 Triclosan 9 vitamin E 8 MAP 7 Cardiovasc 4 Asn 3 caffeine 3 ascorbate 3 Leaf 3 Monit 3 Rosiglitazone 3 Sodium dichloroacetate 3 Fragment 3 Alanine 3 Amiloride 2 Heme 2 Itraconazole 2 Amiloride 2 Retinoic acid 2 Portal 2 AMC 2 Gleevec 2 Simvastatin 2 Imatinib 2 Troglitazone 2 NVP 2 Ouabain 2 Glycyrrhiza 2 RAL 2 ICI 2 Red ginseng 1 GEO 1 AHF 1 PCP 1 ROC 1 ALA 1 Angiotensin II 1 Kenyan 1 Forskolin 1 CSF 1 Japanese encephalitis vaccine 1 Ranolazine 1 Ketoconazole 1 TMS 1 EE2 1 Herceptin 1 Glycerol 1 TAK 1 CaCl2 1 Etoposide 1 ABC 1 Etodolac 1 OTC 1 Parkin 1 Exenatide 1 Ginseng 1 Nitric Oxide 1 Azithromycin 1 uPA 1 Erlotinib 1 Zmax 1 Gefitinib 1 Bortezomib 1 Rituximab 1 Diisopropylamine dichloroacetate 1 OTC 1 CER 1 Glucagon 1 Ranolazine 1 Nephron 1 CaCl2 1 IFN-gamma 1 Flavopiridol 1 ADM 1 niacin 1 Asthma 1 CaCl2 1 more...

Enzyme PDK1 2238 pyruvate dehydrogenase 470 pyruvate dehydrogenase 337 pyruvate dehydrogenase 337 protein kinase 258 mitogen-activated protein kinase 175 focal adhesion kinase 148 ERK 145 protein kinase C 134 phosphatidylinositol 3-kinase 85 MEK 63 AMP-activated protein kinase 60 phosphoinositide 3-kinase 58 ACE 57 PDH 56 AMPK 46 GSK 37 lactate dehydrogenase 37 AMPK 35 CPT 34 luciferase 34 pyruvate dehydrogenase phosphatase 33 caspase-3 31 calcineurin 26 pyruvate kinase 20 hexokinase 19 superoxide dismutase 18 glutathione S-transferase 18 HK2 17 ATPase 16 phosphoenolpyruvate carboxykinase 16 phosphofructokinase 15 PARP 14 CPT 13 CPT 13 complex I 13 IKK 12 catalase 12 TOR 12 STK2 12 cdc2 12 acetyl-CoA carboxylase 12 caspase-9 11 citrate synthase 11 phosphoenolpyruvate carboxykinase 11 hormone-sensitive lipase 11 phosphoenolpyruvate carboxykinase 11 NADPH oxidase 10 prolyl hydroxylase 10 phospholipase C 9 PKG 9 lipoate acetyltransferase 9 proteasome 9 glucose-6-phosphate dehydrogenase 8 NADPH oxidase 8 glucokinase 7 thrombin 7 protein phosphatase 2A 7 pyruvate carboxylase 7 caspase-8 6 isocitrate dehydrogenase 6 glutaminase 6 succinate dehydrogenase 6 glucose-6-phosphatase 6 isocitrate dehydrogenase 6 glyceraldehyde-3-phosphate dehydrogenase 6 RNA polymerase 6 ACS 6 acyl-CoA dehydrogenase 6 lipoprotein lipase 6 phosphodiesterase 5 MAP 5 creatine kinase 5 LPL 5 thymidine kinase 5 APC 5 phospholipase D 5 cytochrome oxidase 5 diaphorase 4 alpha-ketoglutarate dehydrogenase 4 more...

Compound glucose 478 oxygen 224 ATP 208 Dec 159 threonine 157 DNA 122 serine 100 acetyl-CoA 74 phosphate 72 Dichloroacetate 67 tyrosine 64 PDH 56 Insulin 52 alanine 49 calcium 49 ADP 48 ADP 46 ADP 46 sodium 43 CoA 42 MEK 36 NADH 36 water 34 NAD 33 glutamate 32 cAMP 29 TCA 29 acetate 24 AMP 24 MDA 24 NAD 24 lysine 23 glutamine 23 glycerol 22 His 22 Pyruvate 22 Clin 20 Asp 20 cysteine 20 hydrogen 20 arginine 19 MTT 19 Cardiol 18 pentose 17 pentose 17 pentose 17 pentose 17 Phosphatidylinositol 14 nitric oxide 14 salt 14 Rapamycin 13 2-oxoglutarate 13 CPT 13 TNF 13 CPT 13 leucine 13 methionine 13 potassium 11 TPP 11 Lactate 10 malonyl-CoA 10 Mg2+ 10 Phe 10 Gly 10 PAP 9 DCA 9 DOCA 9 alloxan 9 DCA 9 PDP 9 retinoic acid 9 palmitic acid 9 PAP 9 ammonium 9 N-acetylcysteine 8 DEN 8 GSH 8 GSH 8 H2O2 8 proline 8 more...

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