Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts: Gene/Protein Disease Symptom Drug Enzyme Compound   Target Concepts: Gene/Protein Disease Symptom Drug Enzyme Compound

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Query: EC:2.7.11.2 (PDK1)
2,238 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .

Human Gene/Protein PDK1 980 pyruvate dehydrogenase kinase 637 PDK 528 pyruvate dehydrogenase 348 insulin 327 PDK4 300 PI3K 256 AKT 223 Mol 220 mTOR 210 ATP 208 pyruvate dehydrogenase complex 201 Sep 143 PDK2 129 PKB 105 phosphatase 101 PTEN 95 protein kinase B 87 PDH 86 phosphatidylinositol 3-kinase 85 PKC 72 ERK 66 threonine 64 MAPK 64 ERK1 59 phosphoinositide 3-kinase 58 S6K1 55 p53 49 glucose transporter 48 peroxisome proliferator-activated receptor 48 PGC 47 Bcl-2 47 ADP 46 caspase-3 45 Pyruvate dehydrogenase 42 phosphorylating 41 MEK 40 PDK3 40 p38 38 insulin receptor 38 more...

Disease cancer 490 tumor 267 diabetes 127 breast cancer 75 obesity 70 tumor growth 68 tumorigenesis 67 type 2 diabetes 47 carcinoma 42 ischemia 41 hepatocellular carcinoma 39 tumor progression 37 colorectal cancer 35 lung cancer 33 heart failure 31 prostate cancer 30 hyperglycemia 28 glioblastoma 28 carcinogenesis 25 colon cancer 25 adenocarcinoma 24 glioma 23 hypertension 23 non-small cell lung cancer 22 leukemia 22 gastric cancer 21 sepsis 20 sepsis 20 MCF 19 stroke 19 Alzheimer's disease 19 pancreatic cancer 17 dengue 17 acute myeloid leukemia 15 neuroblastoma 15 metastases 15 ovarian cancer 14 squamous cell carcinoma 13 hyperinsulinemia 13 lactic acidosis 13 more...

Symptom starvation 70 exhaustion 8 fatigue 6 pain 6 weakness 5 acidity 5 cachexia 5 seizures 4 hypothermia 3 overweight 3 hunger 2 ataxia 2 anesthesia 2 tremor 2 collapse 2 anorexia 2 eye pain 1 polyuria 1 functional recovery 1 skin damage 1 numbness 1 memory loss 1 Ill 1 hyperoxia 1 neurological disability 1 headache 1 ophthalmoplegia 1 acute stress 1 dry eye 1 decreased appetite 1 HSA 1 flushing 1 sore throat 1 myalgia 1 pelvic pain 1

Drug NADH 36 ROS 33 lysine 19 citric acid 11 Triclosan 9 vitamin E 8 MAP 7 Cardiovasc 4 Leaf 3 Asn 3 caffeine 3 Rosiglitazone 3 Fragment 3 Alanine 3 Sodium dichloroacetate 3 ascorbate 3 Monit 3 Troglitazone 2 Portal 2 Imatinib 2 Itraconazole 2 Simvastatin 2 Retinoic acid 2 Amiloride 2 Amiloride 2 AMC 2 ICI 2 Gleevec 2 Ouabain 2 Heme 2 Glycyrrhiza 2 NVP 2 RAL 2 Ginseng 1 GEO 1 Bortezomib 1 ROC 1 Kenyan 1 Diisopropylamine dichloroacetate 1 Forskolin 1 more...

Enzyme PDK1 2238 pyruvate dehydrogenase 470 pyruvate dehydrogenase 337 pyruvate dehydrogenase 337 protein kinase 258 mitogen-activated protein kinase 175 focal adhesion kinase 148 ERK 145 protein kinase C 134 phosphatidylinositol 3-kinase 85 MEK 63 AMP-activated protein kinase 60 phosphoinositide 3-kinase 58 ACE 57 PDH 56 AMPK 46 GSK 37 lactate dehydrogenase 37 AMPK 35 CPT 34 luciferase 34 pyruvate dehydrogenase phosphatase 33 caspase-3 31 calcineurin 26 pyruvate kinase 20 hexokinase 19 superoxide dismutase 18 glutathione S-transferase 18 HK2 17 ATPase 16 phosphoenolpyruvate carboxykinase 16 phosphofructokinase 15 PARP 14 CPT 13 complex I 13 CPT 13 cdc2 12 IKK 12 catalase 12 TOR 12 more...

Compound glucose 478 oxygen 224 ATP 208 Dec 159 threonine 157 DNA 122 serine 100 acetyl-CoA 74 phosphate 72 Dichloroacetate 67 tyrosine 64 PDH 56 Insulin 52 alanine 49 calcium 49 ADP 48 ADP 46 ADP 46 sodium 43 CoA 42 MEK 36 NADH 36 water 34 NAD 33 glutamate 32 cAMP 29 TCA 29 MDA 24 NAD 24 acetate 24 AMP 24 glutamine 23 lysine 23 glycerol 22 His 22 Pyruvate 22 hydrogen 20 Asp 20 Clin 20 cysteine 20 more...

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