Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:2.7.11.2 (PDK1)
 2,238 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
PDK1 980
pyruvate dehydrogenase kinase 637
PDK 528
pyruvate dehydrogenase 348
insulin 327
PDK4 300
PI3K 256
AKT 223
Mol 220
mTOR 210
ATP 208
pyruvate dehydrogenase complex 201
Sep 143
PDK2 129
PKB 105
phosphatase 101
PTEN 95
protein kinase B 87
PDH 86
phosphatidylinositol 3-kinase 85
PKC 72
ERK 66
threonine 64
MAPK 64
ERK1 59
phosphoinositide 3-kinase 58
S6K1 55
p53 49
peroxisome proliferator-activated receptor 48
glucose transporter 48
Bcl-2 47
PGC 47
ADP 46
caspase-3 45
Pyruvate dehydrogenase 42
phosphorylating 41
MEK 40
PDK3 40
p38 38
insulin receptor 38
NADH 37
SGK1 36
AMPK 35
IRS-1 35
lactate dehydrogenase 34
cyclin D1 33
PDK4 protein 33
ROS 33
pleckstrin 33
PI3 32
GSK 32
vascular endothelial growth factor 31
JNK 30
PKA 30
lactate dehydrogenase A 29
TCA 28
PH domain 28
rhabdomyosarcoma 28
tyrosine kinase 27
AMP-activated protein kinase 27
p21 26
LDHA 26
p70 26
GLUT4 26
GLUT1 26
catenin 25
NAD 24
VEGF 24
AMP 23
MEK1 23
SGK 22
UCP3 22
peroxisome proliferator-activated receptor gamma 22
serine/threonine kinase 22
cytokine 22
pyruvate dehydrogenase kinase 4 21
insulin-like growth factor 21
PPAR 21
p85 21
EGF 21
p27 21
IGF-1 21
HIF-1 20
ribosomal S6 kinase 20
STK1 19
pyruvate kinase 19
NMR 19
collagen 19
hexokinase 19
GSK3 19
PKM2 19
EGFR 18
4E-BP1 18
CD36 18
c-Myc 17
lipopolysaccharide 17
PIK3CA 17
HK2 17
IL-6 17
AKT1 17
epidermal growth factor 17
SGK3 16
epidermal growth factor receptor 16
LC3 16
PI3-kinase 16
CREB 16
RSK 16
ribosomal protein S6 16
PIP3 15
ATPase 15
histone 15
carnitine palmitoyltransferase 15
cytochrome c 15
TSC2 15
p70 S6 kinase 14
CPT1 14
phosphofructokinase 14
caspase-9 14
protein phosphatase 14
receptor tyrosine kinase 14
ubiquitin 14
endoplasmic reticulum 13
TNF 13
PtdIns 13
glycogen synthase 13
UTR 13
ENaC 13
PARP 13
CPT 13
PP2A 13
PIF 13
extracellular signal-regulated kinase 13
pyruvate kinase M2 13
superoxide dismutase 13
STAT3 13
BAD 12
IRS-2 12
HIF-1alpha 12
p65 12
RhoA 12
beta-catenin 12
TORC2 12
TOR 12
acetyl-CoA carboxylase 12
SIRT1 12
3-phosphoinositide-dependent protein kinase 1 12
RAF 12
hexokinase 2 12
mitogen-activated protein 12
insulin receptor substrate 11
PDPK1 11
p90 11
histone deacetylase 11
catalase 11
PDC 11
BRAF 11
HER2 11
Rho 11
MYC 11
citrate synthase 11
more...
Disease
cancer 490
tumor 267
diabetes 127
breast cancer 75
obesity 70
tumor growth 68
tumorigenesis 67
type 2 diabetes 47
carcinoma 42
ischemia 41
hepatocellular carcinoma 39
tumor progression 37
colorectal cancer 35
lung cancer 33
heart failure 31
prostate cancer 30
glioblastoma 28
hyperglycemia 28
carcinogenesis 25
colon cancer 25
adenocarcinoma 24
glioma 23
hypertension 23
non-small cell lung cancer 22
leukemia 22
gastric cancer 21
sepsis 20
sepsis 20
stroke 19
MCF 19
Alzheimer's disease 19
dengue 17
pancreatic cancer 17
metastases 15
neuroblastoma 15
acute myeloid leukemia 15
ovarian cancer 14
hyperinsulinemia 13
lactic acidosis 13
squamous cell carcinoma 13
metabolic syndrome 12
depression 11
lymphoma 11
tuberous sclerosis 11
glucose intolerance 11
hyperthyroidism 11
PDC 11
myocardial infarction 11
cardiovascular disease 11
cold 11
melanoma 11
FAS 10
cervical cancer 10
glioblastoma multiforme 10
PDP 9
Parkinson's disease 9
atherosclerosis 8
brain tumor 8
plaque 8
GSH 8
cerebral ischemia 8
Blocking 8
fatty liver 8
renal cell carcinoma 8
hypoglycemia 7
peripheral neuropathy 7
sickle cell disease 7
hyperlipidemia 7
vascular disease 7
osteosarcoma 7
aggressiveness 7
Hippel 7
lung carcinoma 7
amyotrophic lateral sclerosis 7
liver cancer 7
ATM 6
ventricular hypertrophy 6
SDS 6
myocardial ischemia 6
dilated cardiomyopathy 6
SCD 6
retinoblastoma 6
Glioblastoma 6
dyslipidemia 6
neuropathy 6
liver cancer 6
B-cell lymphoma 5
polycystic kidney 5
pulmonary hypertension 5
solid tumor 5
hypercholesterolemia 5
blindness 5
APC 5
virus infection 5
myopathy 5
Charcot-Marie-Tooth disease 5
cognitive impairment 5
bladder cancer 5
AGS 5
tumor angiogenesis 5
diabetic nephropathy 5
mammary tumor 5
endometrial cancer 4
epithelial ovarian cancer 4
autoimmune disease 4
NS3 4
multiple myeloma 4
pertussis 4
malnutrition 4
Huntington's disease 4
right heart failure 4
rheumatoid arthritis 4
Neuroblastoma 4
cardiomyopathy 4
MRS 4
Neuroblastoma 4
SAR 4
epilepsy 4
diabetic retinopathy 4
anemia 4
Evans 4
HGF 4
hepatitis C 3
type 1 diabetes 3
Pineal 3
renal cancer 3
PDB 3
PDH deficiency 3
brain cancer 3
leukemogenesis 3
osteoporosis 3
adenoma 3
SCID 3
hematologic malignancies 3
worms 3
AS1 3
congestive heart failure 3
heart disease 3
chronic lymphocytic leukemia 3
immunodeficiency 3
EMT 3
colitis 3
chronic myeloid leukemia 3
ABL 3
viremia 3
HTS 3
abortion 3
meningioma 3
dementia 3
NF2 3
Japanese encephalitis 3
Leigh syndrome 3
Melanoma 3
polycythemia 3
Hepatocellular carcinoma 3
RP11 3
renal disease 3
thyroid cancer 3
WT1 3
herpes simplex 3
more...
Symptom
starvation 70
exhaustion 8
fatigue 6
pain 6
weakness 5
acidity 5
cachexia 5
seizures 4
hypothermia 3
overweight 3
hunger 2
ataxia 2
anesthesia 2
tremor 2
collapse 2
anorexia 2
eye pain 1
polyuria 1
functional recovery 1
skin damage 1
numbness 1
memory loss 1
Ill 1
hyperoxia 1
neurological disability 1
headache 1
ophthalmoplegia 1
acute stress 1
dry eye 1
decreased appetite 1
HSA 1
flushing 1
sore throat 1
myalgia 1
pelvic pain 1
Drug
NADH 36
ROS 33
lysine 19
citric acid 11
Triclosan 9
vitamin E 8
MAP 7
Cardiovasc 4
caffeine 3
ascorbate 3
Monit 3
Rosiglitazone 3
Asn 3
Alanine 3
Sodium dichloroacetate 3
Leaf 3
Fragment 3
Gleevec 2
AMC 2
Ouabain 2
Troglitazone 2
Heme 2
Retinoic acid 2
Amiloride 2
Portal 2
Itraconazole 2
Amiloride 2
Imatinib 2
NVP 2
Simvastatin 2
Glycyrrhiza 2
RAL 2
ICI 2
Red ginseng 1
GEO 1
AHF 1
PCP 1
ROC 1
ALA 1
Angiotensin II 1
Kenyan 1
Forskolin 1
CSF 1
Japanese encephalitis vaccine 1
Ranolazine 1
Ketoconazole 1
TMS 1
EE2 1
KGF 1
Hymenialdisine 1
NOV 1
Cilostazol 1
TAK 1
CaCl2 1
Taxol 1
MRC 1
Etodolac 1
OTC 1
Parkin 1
Exenatide 1
Ginseng 1
uPA 1
Nitric Oxide 1
Azithromycin 1
Bortezomib 1
Erlotinib 1
Zmax 1
Gefitinib 1
Diisopropylamine dichloroacetate 1
Rituximab 1
OTC 1
CER 1
CaCl2 1
Glucagon 1
Ranolazine 1
Nephron 1
Glycerol 1
Herceptin 1
Etoposide 1
IFN-gamma 1
Flavopiridol 1
ADM 1
niacin 1
Parkin 1
ABC 1
Asthma 1
CaCl2 1
Sorafenib 1
Fructose 1
Gel 1
Enzyme
PDK1 2238
pyruvate dehydrogenase 470
pyruvate dehydrogenase 337
pyruvate dehydrogenase 337
protein kinase 258
mitogen-activated protein kinase 175
focal adhesion kinase 148
ERK 145
protein kinase C 134
phosphatidylinositol 3-kinase 85
MEK 63
AMP-activated protein kinase 60
phosphoinositide 3-kinase 58
ACE 57
PDH 56
AMPK 46
lactate dehydrogenase 37
GSK 37
AMPK 35
CPT 34
luciferase 34
pyruvate dehydrogenase phosphatase 33
caspase-3 31
calcineurin 26
pyruvate kinase 20
hexokinase 19
superoxide dismutase 18
glutathione S-transferase 18
HK2 17
phosphoenolpyruvate carboxykinase 16
ATPase 16
phosphofructokinase 15
PARP 14
CPT 13
complex I 13
CPT 13
cdc2 12
catalase 12
acetyl-CoA carboxylase 12
TOR 12
IKK 12
STK2 12
hormone-sensitive lipase 11
phosphoenolpyruvate carboxykinase 11
phosphoenolpyruvate carboxykinase 11
citrate synthase 11
caspase-9 11
NADPH oxidase 10
prolyl hydroxylase 10
phospholipase C 9
lipoate acetyltransferase 9
PKG 9
proteasome 9
glucose-6-phosphate dehydrogenase 8
NADPH oxidase 8
pyruvate carboxylase 7
glucokinase 7
thrombin 7
protein phosphatase 2A 7
glucose-6-phosphatase 6
succinate dehydrogenase 6
acyl-CoA dehydrogenase 6
lipoprotein lipase 6
glyceraldehyde-3-phosphate dehydrogenase 6
isocitrate dehydrogenase 6
glutaminase 6
ACS 6
caspase-8 6
RNA polymerase 6
isocitrate dehydrogenase 6
creatine kinase 5
phosphodiesterase 5
phospholipase D 5
MAP 5
LPL 5
cytochrome oxidase 5
thymidine kinase 5
APC 5
alpha-ketoglutarate dehydrogenase 4
branched-chain alpha-keto acid dehydrogenase 4
glyceraldehyde-3-phosphate dehydrogenase 4
trypsin 4
glutamine synthetase 4
diaphorase 4
phosphorylase 4
polo-like kinase 1 4
DNA methyltransferase 4
transcriptase 4
NO synthase 4
acyl-CoA dehydrogenase 3
6-phosphofructo-2-kinase 3
inositol phosphatase 3
phospholipase A2 3
TACE 3
pyruvate decarboxylase 3
glutathione peroxidase 3
diaphorase 3
alanine aminotransferase 3
malate dehydrogenase 3
chymotrypsin 3
BCKDH 3
CPR 3
adenylate cyclase 3
AMP-activated kinase 3
demethylase 3
STK3 3
alkaline phosphatase 3
farnesyltransferase 3
farnesyltransferase 3
glutathione synthetase 3
ATP synthase 3
3-hydroxyacyl-CoA dehydrogenase 3
histone demethylase 2
phosphoribulokinase 2
PDE 2
CEP 2
succinyl-CoA synthetase 2
PHT 2
glucose oxidase 2
glutamate dehydrogenase 2
PHD 2
TPP 2
glutamate dehydrogenase 2
GRK2 2
xanthine oxidase 2
collagenase 2
CaMKII 2
glycogenin 2
phosphorylase kinase 2
MEKK1 2
malonyl-CoA decarboxylase 2
STK11 2
aldolase 2
fructose 1,6-bisphosphatase 2
histidine kinase 2
reverse transcriptase 2
glutamate dehydrogenase 2
CEP 2
ALDH 2
TdT 2
TPP 2
alcohol dehydrogenase 1
endonuclease 1
acyl-CoA synthetase 1
transketolase 1
fumarase 1
SPC 1
neutral sphingomyelinase 1
cystathionine beta-synthase 1
acyl-CoA oxidase 1
PAH 1
SCS 1
urease 1
adenosine deaminase 1
MDR 1
glycerol-3-phosphate dehydrogenase 1
CYP7A1 1
arylsulfatase 1
adenosine deaminase 1
2,4-dienoyl-CoA reductase 1
more...
Compound
glucose 478
oxygen 224
ATP 208
Dec 159
threonine 157
DNA 122
serine 100
acetyl-CoA 74
phosphate 72
Dichloroacetate 67
tyrosine 64
PDH 56
Insulin 52
alanine 49
calcium 49
ADP 48
ADP 46
ADP 46
sodium 43
CoA 42
NADH 36
MEK 36
water 34
NAD 33
glutamate 32
cAMP 29
TCA 29
NAD 24
MDA 24
acetate 24
AMP 24
lysine 23
glutamine 23
glycerol 22
Pyruvate 22
His 22
Clin 20
hydrogen 20
Asp 20
cysteine 20
arginine 19
MTT 19
Cardiol 18
pentose 17
pentose 17
pentose 17
pentose 17
Phosphatidylinositol 14
nitric oxide 14
salt 14
methionine 13
2-oxoglutarate 13
CPT 13
CPT 13
leucine 13
TNF 13
Rapamycin 13
potassium 11
TPP 11
Phe 10
Lactate 10
Mg2+ 10
Gly 10
malonyl-CoA 10
PDP 9
alloxan 9
palmitic acid 9
PAP 9
DCA 9
DOCA 9
ammonium 9
DCA 9
PAP 9
retinoic acid 9
N-acetylcysteine 8
proline 8
iron 8
Hearts 8
GSH 8
DEN 8
GSH 8
H2O2 8
Hearts 7
boron 7
nitrogen 7
Wortmannin 7
Serine 6
valine 6
urea 6
DMSO 6
GTP 6
nicotinamide 6
MAP 6
NH2 6
Adriamycin 6
zinc 6
bromide 6
ADR 6
DDP 6
acetamide 6
SDS 6
ACS 6
tryptophan 6
ACS 6
COX 6
acetamide 6
palmitic acid 6
sulfate 6
tryptophan 5
aspartic acid 5
tryptophan 5
ethanol 5
PMA 5
aspartic acid 5
Panam 5
CO2 5
pyrimidine 5
AGE 5
aspartic acid 5
tryptophan 5
dUTP 5
Metformin 5
Metformin 5
pyrimidine 5
Melatonin 5
aspartic acid 5
Quercetin 5
cGMP 5
WY-14,643 4
Celecoxib 4
TOF 4
Pro-Gly 4
L-carnitine 4
glucose-6-phosphate 4
glutamic acid 4
Curcumin 4
phosphocreatine 4
5-FU 4
galactose 4
PPI 4
TSC 4
BCR 4
Cholesterol 3
Tyrosine 3
quinazoline 3
acetic acid 3
silver 3
cadmium 3
TACE 3
pyridine 3
quinazoline 3
5-HT 3
cyanide 3
PGE2 3
Alanine 3
cobalt 3
Tamoxifen 3
Austin 3
CAM 3
LY 294002 3
more...