Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:2.7.11.2 (
PDK1
)
2,238
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Kaempferol
is a dietary flavonoid that is thought to function as a selective estrogen receptor modulator. In this study, we established that
kaempferol
also functions as an inverse agonist for estrogen-related receptors alpha and gamma (ERRalpha and ERRgamma). We demonstrated that
kaempferol
binds to ERRalpha and ERRgamma and blocks their interaction with coactivator peroxisome proliferator-activated receptor gamma coactivator-1alpha (PGC-1alpha).
Kaempferol
also suppressed the expressions of ERR-target genes
pyruvate dehydrogenase kinase
2 and 4 (
PDK2
and
PDK4
). This evidence suggests that
kaempferol
may exert some of its biological effect through both estrogen receptors and estrogen-related receptors.
...
PMID:Kaempferol is an estrogen-related receptor alpha and gamma inverse agonist. 1917 Nov 40
