Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:2.7.11.2 (
PDK1
)
2,238
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The
eukaryotic translation initiation factor 4B
(
eIF4B
) plays a critical role in recruiting the 40S ribosomal subunit to the mRNA. In response to insulin,
eIF4B
is phosphorylated on Ser422 by S6K in a rapamycin-sensitive manner. Here we demonstrate that the p90 ribosomal protein S6 kinase (RSK) phosphorylates
eIF4B
on the same residue. The relative contribution of the RSK and S6K modules to the phosphorylation of
eIF4B
is growth factor-dependent, and the two phosphorylation events exhibit very different kinetics. The S6K and RSK proteins are members of the AGC protein kinase family, and require
PDK1
phosphorylation for activation. Consistent with this requirement, phosphorylation of
eIF4B
Ser422 is abrogated in
PDK1
null embryonic stem cells. Phosphorylation of
eIF4B
on Ser422 by RSK and S6K is physiologically significant, as it increases the interaction of
eIF4B
with the eukaryotic translation initiation factor 3.
...
PMID:The mTOR/PI3K and MAPK pathways converge on eIF4B to control its phosphorylation and activity. 1676 66
