Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:2.7.11.2 (
PDK1
)
2,238
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Pathological anxiety is paralleled by deficits in serotonergic and GABAergic neurotransmission in the amygdala. Conversely,
anxiety disorders
and depression may be reversed by brain-derived neurotrophic factor (BDNF). BDNF signaling involves Phosphatidylinositol 3-Kinase / 3-phosphoinositide-dependent protein kinase 1 (PI3K/
PDK1
). We thus hypothesized that impaired function of
PDK1
might be associated with increased anxiety and concomitant neurotransmitter changes. Here we used the hypomorphic
PDK1
(hm) mouse to investigate anxiety behavior in different settings:
PDK1
(hm) mice differed from Wt littermates
PDK1
(WT) in several behavioral measures related to anxiety and exploration, namely in the open field, dark-light box, O-maze and startle response. Further we analyzed the brain substrate underlying this phenotype and found significantly decreased GABA, taurine and serotonin concentrations in the amygdala and olfactory bulb of
PDK1
(hm) mice, while BDNF and nerve growth factor (NGF) concentrations were not significantly different between
PDK1
(hm) and
PDK1
(WT) mice. These results suggest that impaired PI3K signaling in the
PDK1
(hm) mouse reduces concentrations of GABA and serotonin in anxiety related brain regions and can serve as a molecular substrate for behavior indicative for anxious and depressive-like mood states.
...
PMID:Phosphatidylinositide dependent kinase deficiency increases anxiety and decreases GABA and serotonin abundance in the amygdala. 1908 55
