Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:2.7.11.17 (CaMKII)
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Human Gene/Protein
PPM1F protein 12.9
CaM kinase II 12.9
Na+/Ca2+ exchanger isoform 3 12.9
CaMKII 12.6
calcium/calmodulin-dependent protein kinase II beta 12.5
CaMKP-N 12.1
signal recognition particle 72 11.9
CaM kinase I 11.9
chromosome 9 open reading frame 10 11.9
WD repeat-containing protein 35 11.9
CaM-KIIN 11.7
Ca(2+)/calmodulin-dependent protein kinase phosphatase 11.6
CaMKI gamma 11.4
KCIP-1 11.4
ADCK1 10.9
splicing factor arginine/serine-rich 3 10.9
HMGCS2 protein 10.9
CaM-kinase IV kinase 10.8
NPH2 10.6
calcium-response factor 10.6
protein phosphatase inhibitor 2 10.6
PNCK 10.6
calmodulin-dependent protein kinase IV 10.6
CaMKK 10.6
cardiac phospholamban 10.4
DCLK3 10.4
TBC1 domain family member 1 10.4
CAMKII 10.2
KIAA0369 10.1
SSH2 10.1
Olfactomedin 1 10.1
Galphai2 protein 10.1
E1A-associated protein p300 10.1
DCAMKL1 10.0
CAMK2N1 10.0
neural cell adhesion molecule 2 9.9
LRRC7 9.9
PPM1F 9.9
FIN13 9.9
histidine-rich calcium binding protein 9.8
type III adenylyl cyclase 9.8
POLE4 9.8
calcium/calmodulin-dependent protein kinase II 9.7
DAP-5 9.6
Glutamate decarboxylase 1 9.6
guanylate kinase-associated protein 9.6
Calcium/calmodulin-dependent protein kinase II 9.5
GPR176 9.5
glutamate decarboxylase GAD65 9.5
HA95 9.5
PLA2G4D 9.5
CDKL3 9.5
Telethonin 9.5
OXSR1 9.5
CAMK 9.5
synapsin I 9.5
GON-2 9.4
TANC1 9.4
heat shock protein beta 9.4
PI-TPbeta 9.4
GKAP 9.3
C114 9.2
neural precursor cell expressed, developmentally down-regulated 8 9.2
ANKS1B 9.2
p32 protein 9.2
Active regulator of SIRT1 9.1
Galpha14 9.1
OSSA 9.1
InsP3R3 9.1
NAD(+) kinase 9.1
calmodulin-dependent protein kinase II alpha 9.1
doublecortin kinase-2 9.1
SLC8A3 9.1
PSD protein 9.1
NLK 9.0
myomegalin 9.0
PPM1E 9.0
ZIP7 9.0
MUPP1 9.0
CLC-3 8.9
EPI64C 8.9
dNT-2 8.9
PCP4 8.9
AIP2 8.9
PEP-19 8.9
P2X purinoceptor 7 8.9
MICAL1 8.9
myocyte-specific enhancer factor 2 8.9
FEM1B 8.9
AKAP220 8.9
calponin 3 8.9
calcium/calmodulin-dependent protein kinase II alpha 8.9
cerebroglycan 8.9
calmodulin 8.9
eEF-2 kinase 8.8
solute carrier family 9 8.8
RICS 8.8
B-50/GAP43 8.8
pf16 8.8
lin-10 8.8
EMI2 8.8
AIP 8.8
IRBIT 8.8
AC3 8.7
HIVEP2 8.7
phospholamban 8.7
Caldesmon 8.7
STO 8.7
RC3 8.7
transforming growth factor-beta-activated kinase 1 8.7
BRSK1 8.7
glycogen synthase kinase 3 alpha 8.7
STK38L 8.7
PP2Calpha 8.7
KSR2 8.6
ARPP-21 8.6
SAP102 8.6
neurogranin 8.6
ZC3H14 8.6
NAT8L 8.6
CASK 8.6
Sepiapterin reductase 8.5
TBC1D1 8.5
synapsin Ib 8.5
CAMK2 8.5
TNF receptor-associated protein 8.5
phosducin-like 8.5
SAP97 8.5
KIF17 8.5
smooth muscle myosin light chain 8.4
Myopodin 8.4
TRPM8 protein 8.4
RyR2 8.4
protein kinase D2 8.4
myopodin 8.4
eIF4GII 8.4
CACNA1E 8.4
HDAC5 8.4
POPX2 8.3
CAMK2B 8.3
actopaxin 8.3
Wnt-5a 8.3
G-substrate 8.2
ADDL 8.2
protein phosphatase 2B 8.2
follistatin-related protein 8.2
GLUR1 8.2
PIAS2 8.2
SRP68 8.2
CAMK2D 8.2
pericentriolar material 1 8.2
cytokeratin 1 8.2
GluR-A 8.2
Ras-related GTP-binding protein 8.1
GRM2 8.1
Kir2.4 8.1
NCKX4 8.1
CHRM1 8.1
PSD-93 8.1
Myosin light chain kinase 8.1
more...
Disease
AIP 8.7
NINA 8.7
AIP 8.7
learning defect 8.3
OBX 8.3
Olfactory nerve 7.9
Flashing 7.5
Transient cerebral ischemia 7.5
Opioid Withdrawal 7.0
LTD 7.0
BGS 6.9
Infection induced 6.8
Cerebral hypoperfusion 6.7
adult brain tumor 6.4
CMD1 6.3
Taybi 6.3
LGMD2A 6.2
Transient ischemia 5.7
Neonatal seizures 5.7
audiogenic seizure 5.6
lymphoblastoma 5.6
CYLD 5.6
AD2 5.5
LQT2 5.4
learning disorder 5.3
Small intestine 5.3
PND 5.2
diabetic hyperglycemia 5.1
memory impairment 5.1
IS3 4.9
Angelman syndrome 4.9
hypoglycemic coma 4.9
Congenital hypothyroidism 4.9
diabetic cardiomyopathy 4.9
physical dependence 4.8
TBS 4.8
cocaine addiction 4.8
Hypertrophic 4.7
EAD 4.7
alpha thalassemia 4.6
ATRX 4.6
lissencephaly 4.4
insulinoma 4.4
Vascular dementia 4.4
FTLD 4.3
hypersexuality 4.3
avian sarcoma 4.2
MLC 4.2
Rous sarcoma 4.2
Opiates 4.2
CSE 4.1
cerebral ischemia 4.1
MDM 4.1
Depressive disorders 4.0
cognitive disorder 3.9
bone cancer 3.9
Frey 3.9
Blocking 3.9
Spinal muscular atrophy 3.9
Chronic heart failure 3.9
neuroblastoma 3.9
fear and anxiety 3.8
limb-girdle muscular dystrophy 3.8
PPP 3.8
MLS 3.7
Habituation 3.7
Ductal 3.7
PTD 3.7
intestinal cancer 3.7
NSD 3.6
heart failure 3.6
pertussis 3.5
LIN 3.5
AIDS dementia complex 3.5
Pulmonary arterial hypertension 3.5
methylmalonic acidemia 3.5
drug addiction 3.5
IVA 3.5
NPS 3.5
HNSCC 3.5
erythroblastosis 3.4
HMR 3.4
tetanus 3.4
respiratory acidosis 3.4
COL2A1 3.4
Medulloblastoma 3.4
pheochromocytoma 3.4
Spinocerebellar ataxia 3.3
mononeuropathy 3.3
Recruitment 3.3
polycystic kidney 3.3
Goldstein 3.3
Pick's disease 3.3
CAM 3.3
retrograde amnesia 3.3
ischemia 3.2
Cerebellum 3.2
AGA 3.1
RGS 3.1
MEC 3.1
Glanzmann's thrombasthenia 3.1
nephrogenic diabetes insipidus 3.1
NAME 3.1
inferior myocardial infarction 3.0
Alzheimer's disease 3.0
myeloid leukemia 3.0
Li-Fraumeni syndrome 3.0
FAS 3.0
intellectual impairment 3.0
APC 3.0
bipolar depression 3.0
congenital hypothyroidism 2.9
dilated cardiomyopathy 2.9
Testis 2.9
Testis 2.9
NPC 2.9
status epilepticus 2.9
TAS 2.9
neuronal ceroid lipofuscinosis 2.9
Osteosarcoma 2.8
Osteosarcoma 2.8
Rett syndrome 2.8
HOS 2.8
cognitive impairment 2.8
drug withdrawal 2.8
secondary hypertension 2.7
bovine leukemia 2.7
PDE 2.6
FTC 2.6
anhedonia 2.6
Schmidt 2.6
depression 2.5
Ischemic stroke 2.5
motion sickness 2.5
gastroparesis 2.5
endotoxic shock 2.5
astrocytoma 2.5
INS 2.5
hepatic encephalopathy 2.4
EMD 2.4
motor neuron disease 2.4
Fox 2.4
familial adenomatous polyposis 2.4
diphtheria 2.4
cardiomyopathy 2.4
movement disorder 2.4
renal cyst 2.4
brain edema 2.4
glioma 2.4
disinhibition 2.4
torsades de pointes 2.3
senile dementia 2.3
epilepsy 2.3
ventricular hypertrophy 2.3
hypothyroidism 2.3
forgetting 2.3
Wells 2.3
SMS 2.3
lymphosarcoma 2.3
Pineal 2.3
more...
Symptom
Mobility Limitations 11.4
rundown 6.0
Cushingoid 5.2
Cushingoid 5.1
disturbed balance 5.1
memory loss 4.1
despair 3.3
hypocapnia 3.2
bone pain 2.9
eds 2.9
abnormal gait 2.8
fasciculation 2.6
Neuropathic pain 2.5
acute stress 2.4
seizures 1.9
ataxia 1.8
exhaustion 1.8
hypercapnia 1.6
hypothermia 1.5
cancer pain 1.4
cerebellar ataxia 1.1
functional recovery 0.8
pain 0.8
hyperoxia 0.6
insomnia 0.6
collapse 0.5
fatigue 0.5
starvation 0.3
respiratory distress 0.3
analgesia 0.2
vomiting -0.0
dystonia -0.1
Ill -0.5
thinning -0.5
sleepiness -0.7
acidity -0.9
anesthesia -1.0
tremor -1.2
discomfort -1.5
nausea -1.6
discomfort -1.6
overweight -1.7
headache -2.8
Drug
Flurothyl 9.0
Valcyte 8.9
Lubeluzole 7.9
K-252a 7.8
Olomoucine 7.5
Sulfadimethoxine 7.3
Aluminum chloride 7.2
Butaprost 7.0
Pimobendan 6.8
Atosiban 6.7
Tianeptine 6.6
Quisqualate 6.5
CG1 6.3
Trifluoperazine 6.2
DFP 6.1
Fluphenazine 6.0
Escitalopram 6.0
Hyperforin 5.9
SNL 5.4
Felodipine 5.4
GHRP 5.4
SMP 5.4
Thioridazine 5.0
Ranolazine 5.0
Ranolazine 5.0
ID2 4.8
IPD 4.7
Dasatinib 4.7
Menthol 4.7
Rimonabant 4.6
AC2 4.5
MDM 4.3
Rolipram 4.2
Liraglutide 4.2
Angiotensin II 4.1
Emodin 4.1
NVP 4.0
Reserpine 4.0
TAK 4.0
Forskolin 3.9
Emodin 3.8
Parkin 3.7
Parkin 3.7
Glide 3.6
Kainic acid 3.6
Pronase 3.6
caffeine 3.5
Everolimus 3.5
MAP 3.5
Glucagon 3.4
Ganciclovir 3.4
Sorafenib 3.4
MgSO4 3.4
Irinotecan 3.3
CAM 3.2
Nitric Oxide 3.2
ROS 3.2
DBS 3.2
APD 3.1
Adenosine triphosphate 3.1
CaCl2 3.1
CaCl2 3.1
DEX 3.1
Photofrin 3.1
PCP 3.1
ETA 3.1
Histamine 3.1
CaCl2 3.1
Monensin 3.0
Luteinizing 2.9
uPA 2.9
Propofol 2.9
Asn 2.9
FLP 2.9
Doxycycline 2.9
Retinoic acid 2.8
Fragment 2.8
RFP 2.7
Ouabain 2.7
ZnCl2 2.6
ZnCl2 2.6
Honey 2.6
Lovastatin 2.6
Phenytoin 2.6
Gel 2.5
ALA 2.5
Gleevec 2.5
BH4 2.4
Allergen 2.4
Ranitidine 2.3
TAC 2.3
Simvastatin 2.3
p75 2.0
Itraconazole 2.0
-deoxyadenosine 1.9
EPI 1.9
DHT 1.8
G418 1.8
Estrogens 1.8
DHT 1.8
Glycerol 1.8
CDP 1.8
L-tyrosine 1.7
TAT 1.7
Ethanol 1.7
Imatinib 1.7
ETS 1.6
ICI 1.6
Growth hormone 1.4
Growth hormone 1.4
Heme 1.3
Taxol 1.3
lysine 1.3
EE2 1.0
IL-2 0.9
ENT 0.9
ABC 0.8
Adriamycin 0.8
CSF 0.6
Glutathione 0.6
FAD 0.5
vitamin E 0.4
Nephron 0.4
Mutagen 0.4
PTH 0.2
NH3 0.2
Leaf 0.1
ROC 0.0
IFN-gamma -0.3
Cardiovasc -0.5
TiO2 -0.5
ascorbate -0.5
Monit -0.6
lactose -1.1
NADH -1.5
Asthma -1.7
Enzyme
CaMKII 12.9
SMP-I 11.4
EC 2.1.1.60 10.6
NSY 9.4
proteasome ATPase 8.9
polo-like kinase 1 8.6
myosin light chain kinase 7.9
eEF2 kinase 7.7
EC 2.4.1.11 7.4
CDP-diacylglycerol synthase 7.3
1-acylglycerol-3-phosphate O-acyltransferase 7.3
AMPK 7.3
calcineurin 7.0
PKG 6.9
protein kinase 6.9
Ins(1,4,5)P3 3-kinase 6.7
type 1 protein phosphatase 6.6
guanylate kinase 6.4
protein kinase C 6.4
sepiapterin reductase 6.4
phosphorylase kinase 6.3
phosphatidylinositol synthase 6.2
PI-PLC 6.1
AMP-activated protein kinase 6.1
protein phosphatase 2A 5.9
PWD 5.9
tryptophan hydroxylase 5.9
AMPK 5.8
calpain 3 5.8
calpain 3 5.7
myosin ATPase 5.6
6-phosphofructo-2-kinase 5.6
calcium pump 5.5
CLK1 5.4
lactose synthetase 5.4
rhodopsin kinase 5.4
tetanus neurotoxin 5.3
dihydropteridine reductase 5.3
factor C 5.2
phosphatidate phosphatase 5.2
MEK 5.2
proton-translocating ATPase 5.1
mu-calpain 5.1
MEKK1 5.1
AMP-activated kinase 5.1
guanase 5.1
phospholipase C 5.1
GSK 5.0
GAR 5.0
clostripain 5.0
mitogen-activated protein kinase 5.0
O-GlcNAc transferase 5.0
acetyl-CoA carboxylase 4.9
p80 4.9
Mg2+-ATPase 4.7
H,K-ATPase 4.7
proline dehydrogenase 4.7
glycerophosphate acyltransferase 4.7
CPT 4.6
MsrA 4.6
diacylglycerol kinase 4.6
MAP 4.6
SMP 4.5
CPT 4.5
phosphatidylinositol 3-kinase 4.4
tyrosine hydroxylase 4.4
PDE 4.4
NOS 4.4
TSA 4.3
CPT 4.2
carnitine acetyltransferase 4.2
12-lipoxygenase 4.2
GRK2 4.2
diacylglycerol acyltransferase 4.2
adenosine kinase 4.1
HMG-CoA synthase 4.0
phosphoinositide 3-kinase 4.0
lysyl endopeptidase 4.0
phosphodiesterase 4.0
phosphoribulokinase 3.9
glyceraldehyde-3-phosphate dehydrogenase 3.9
glyceraldehyde-3-phosphate dehydrogenase 3.8
cdc2 3.8
meprin 3.8
HK2 3.8
cytochrome P-450scc 3.8
GRK5 3.8
adenylate cyclase 3.8
glyceraldehyde-3-phosphate dehydrogenase 3.7
guanylate cyclase 3.7
ATPase 3.6
ERK 3.6
NADPH oxidase 3.6
NADPH oxidase 3.6
arylalkylamine N-acetyltransferase 3.6
phosphatidylinositol 4-kinase 3.5
acrosin 3.5
monoacylglycerol lipase 3.5
phenylalanine hydroxylase 3.5
glyceraldehyde-3-phosphate dehydrogenase 3.5
NO synthase 3.5
kinesin 3.5
glycerol kinase 3.4
DAT 3.4
insulin-degrading enzyme 3.4
sphingosine kinase 3.4
phospholipase D 3.4
ubiquitin-protein ligase 3.3
phosphorylase 3.3
glyceraldehyde-3-phosphate dehydrogenase 3.3
m-calpain 3.3
IKK 3.3
pyruvate kinase 3.2
phospholipase A2 3.1
p100 3.1
trehalase 3.1
Pla 3.1
histone acetyltransferase 3.1
cathepsin K 3.1
PCP 3.1
cGMP phosphodiesterase 3.0
chloramphenicol acetyltransferase 3.0
farnesyltransferase 2.9
DOPA decarboxylase 2.9
choline acetyltransferase 2.9
PDK1 2.8
luciferase 2.8
histidine kinase 2.7
chymotrypsin 2.7
arylsulfatase 2.7
xanthine dehydrogenase 2.7
CPS 2.6
phosphoglucomutase 2.5
focal adhesion kinase 2.5
heme oxygenase 2.5
glutathione S-transferase 2.5
purine nucleoside phosphorylase 2.5
gamma-glutamylcysteine synthetase 2.5
caspase-3 2.5
proteasome 2.5
lipoxygenase 2.4
histidine decarboxylase 2.4
farnesyltransferase 2.4
thrombin 2.4
triphosphatase 2.4
apyrase 2.4
NQO1 2.4
Alternating 2.3
beta-galactosidase 2.3
APC 2.3
dipeptidyl peptidase IV 2.2
phosphoglucose isomerase 2.2
paraoxonase 2.2
aldolase 2.2
ATP synthase 2.2
prostate-specific membrane antigen 2.2
prostaglandin synthetase 2.1
glutaminase 2.1
cathepsin L 2.0
BAL 2.0
more...
Compound
4-methoxybenzenesulfonamide 10.8
Pratensein 10.6
5-isoquinolinesulfonic acid 10.1
4-aminocyclohexanecarboxylic acid 9.8
4-aminocyclohexanecarboxylic acid 9.8
Ap(6)A 8.9
Echinocystic acid 8.9
KIV 8.8
Scytalone 8.8
Diisopropyl 8.6
Chicago Sky Blue 6B 8.6
2-naphthalenesulfonamide 8.5
3,4-D 8.2
FPL64176 8.0
Phosphorylase b 7.9
BayK8644 7.7
8-Bromoadenosine 7.6
8-Bromoadenosine 7.6
8-Bromoadenosine 7.6
8-Bromoadenosine 7.6
8-Bromoadenosine 7.6
8-Bromoadenosine 7.6
8-Bromoadenosine 7.6
12-hydroperoxyeicosatetraenoic acid 7.5
Berbamine 7.5
DNC 7.4
Calyculin A 7.2
A-7 7.2
Chelerythrine 7.1
Chelerythrine 7.1
Gadolinium chloride 7.1
LTD 7.0
N6-Methyladenosine 6.9
AMPA 6.9
Chrysophanol 6.8
CMK 6.8
Chrysophanol 6.8
2-aminoethyl diphenylborinate 6.7
Aniracetam 6.7
2-aminoethyl diphenylborinate 6.7
7-Ketocholesterol 6.7
Imperatorin 6.7
2-methylpiperazine 6.6
5-methylisoxazole 6.6
TOCP 6.5
Okadaic acid 6.5
NMDA 6.5
Ryanodine 6.5
Monocrotaline 6.4
succinamide 6.4
Hyperoside 6.3
Cyclic ADP-ribose 6.3
APV 6.2
GF 109203X 6.2
Trifluoperazine 6.2
1H-pyrrole-2,5-dione 6.1
NBQX 6.1
Aconitine 6.1
Aconitine 6.1
Fluphenazine 6.0
RBA 6.0
1H-indazole 6.0
22R-hydroxycholesterol 5.9
Hyperforin 5.9
Dantrolene 5.9
Evodiamine 5.9
Staurosporine 5.8
MK801 5.8
2-pyrrolidinone 5.8
Thapsigargin 5.8
Evodiamine 5.8
Sinomenine 5.8
Staurosporine 5.8
CBN 5.7
Paeoniflorin 5.7
threonine 5.7
phosphoserine 5.6
3-(dimethylamino)propyl 5.6
Temsirolimus 5.6
methoxyacetic acid 5.5
Osthole 5.5
VO4 5.5
Nobiletin 5.4
9-octadecenoic acid 5.4
9-octadecenoic acid 5.4
9-octadecenoic acid 5.4
calcium 5.4
C12H8N2 5.4
Aspartame 5.3
Isoform 5.3
Mr 30 5.3
Tetramethylpyrazine 5.2
GAR 5.2
cAMP 5.2
Dibutyryl cyclic AMP 5.2
Dibutyryl cyclic AMP 5.2
Herbimycin 5.2
8-Br-cGMP 5.2
9-octadecenoic acid 5.2
Veratridine 5.1
2-pyrrolidinone 5.1
DHF 5.1
BBM 5.1
TBS 5.1
Naringin 5.0
Nisoldipine 5.0
chloroacetic acid 5.0
PPADS 5.0
2-hydroxyethyl 5.0
2-hydroxyethyl 5.0
2-hydroxyethyl 5.0
Cyproterone acetate 5.0
2-hydroxyethyl 5.0
2-hydroxyethyl 5.0
2-hydroxyethyl 5.0
2-hydroxyethyl 5.0
Ang II 5.0
Glutamate 4.9
Formin 4.9
Nifedipine 4.9
DLG 4.9
MEK 4.9
Allyl isothiocyanate 4.9
D-Serine 4.8
Glu-Glu 4.8
serine 4.8
OPE 4.8
LY 294002 4.8
Wortmannin 4.8
IPD 4.8
cGMP 4.7
Betulinic acid 4.7
Genistein 4.7
AMP 4.7
Hearts 4.7
Naringin 4.7
Carbachol 4.7
glutamate 4.7
Serine 4.7
Memantine 4.7
IDP 4.7
Honokiol 4.7
2-hydroxyethyl 4.7
Menthol 4.6
CPT 4.6
Linolenic acid 4.6
Fluo-3 4.6
isoquinoline 4.6
Neuronal 4.6
20-HETE 4.6
Celastrol 4.6
Phorbol 4.5
Menthol 4.5
E-4031 4.5
DHPG 4.5
CPT 4.5
Remifentanil 4.5
PMA 4.5
Ins(1,4,5)P3 4.4
VPM 4.4
more...