Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:2.7.11.17 (
CaMKII
)
4,029
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Ankyrin repeat and sterile alpha motif domain-containing protein 1B
(ANKS1B, also known as
AIDA-1
) is a major component of the postsynaptic density (PSD) in excitatory neurons where it concentrates at the electron-dense core under basal conditions and moves out during activity. This study investigates the molecular mechanism underlying activity-induced displacement of
AIDA-1
. Experiments with PSD fractions from brain indicate phosphorylation of
AIDA-1
upon activation of endogenous
CaMKII
. Immuno-electron microscopy studies show that treatment of hippocampal neurons with NMDA results in an ~ 30 nm shift in the median distance of the
AIDA-1
label from the postsynaptic membrane, an effect that is blocked by the
CaMKII
inhibitor tatCN21.
CaMKII
-mediated redistribution of
AIDA-1
is similar to that observed for SynGAP.
CaMKII
-mediated removal of two abundant PSD-95-binding proteins from the PSD core during activity is expected to initiate a molecular reorganization at the PSD.
...
PMID:CaMKII-mediated displacement of AIDA-1 out of the postsynaptic density core. 2747 89
