Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:2.7.11.17 (
CaMKII
)
4,029
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
We previously reported that cells other than mast cells or neurons could synthesize histamine in response to lipopolysaccharide (LPS) or interleukin 1beta in the rat brain. To identify the responsible cells, we examined histidine decarboxylase (HDC) activity and the expression of HDC mRNA in
GMI
6-3 mouse microglial cells. Both the activity and mRNA for HDC in
GMI
6-3 cells were induced by LPS treatment, and the induction was sensitive to
calmodulin-dependent kinase II
inhibitor, KN62. These findings indicate that microglia is a third cell type producing histamine in the brain.
...
PMID:Histamine production by cultured microglial cells of the mouse. 1140 35
