Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:2.7.11.17 (
CaMKII
)
4,029
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Although the expression of
CaMKII
and synaptic-associated proteins has been widely studied, the temporospatial distribution of
CaMKII
and NMDAR subunits in different hippocampal subregions during postnatal development still lacks detailed information. In this study, we used immunofluorescent staining to assess
CaMKII
and NR2B expressions and the relationship between them in CA1, CA3, and DG of rat hippocampus on postnatal (P) days: P0, P4, P7, P10, P14, P21, P28, and
P56
. The results showed that from P0 to
P56
,
CaMKII
expression increased gradually, while NR2B expression decreased gradually, and the time points of their expression peak differed in CA1, CA3, and DG during postnatal development. Although the expression of
CaMKII
was negatively correlated with NR2B in CA1 and DG, the coexpression of
CaMKII
with NR2B existed in CA1, CA3, and DG during postnatal development. Interestingly, after P21,
CaMKII
expression and the coexpression of
CaMKII
with NR2B became obvious in the Stratum lucidum of CA3. The specific temporospatial distribution pattern of
CaMKII
with NR2B might be related to the different physiological functions during postnatal development. Discovery of the alteration of the relationship between expression of
CaMKII
and NMDAR subunits may be helpful for understanding mechanisms and therapy of neurodegenerative diseases.
...
PMID:Immunolocalization of CaMKII and NR2B in hippocampal subregions of rat during postnatal development. 2290 54
