Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:2.7.11.17 (
CaMKII
)
4,029
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
We examined effects of an isoquinolinesulfonamide derivative, KN-62, on human ovarian cancer cells, NOS3AR, that are resistant to
Adriamycin
(
ADR
). MTT assay revealed that 10 microM KN-62 overcame the resistance. KN-62 had little effect on GST activity. In studies on the intracellular accumulation of
ADR
, KN-62 increased the
ADR
contents in the resistant cells close to the level seen in the sensitive cells. These results suggest that the reversal of the resistance against
ADR
in ovarian cancer cells by KN-62 is mainly due to higher accumulation of
ADR
in NOS3AR cells. Furthermore, we detected
Ca2+/calmodulin-dependent protein kinase II
(
CaM kinase II
) in NOS3AR cells since KN-62 is a specific inhibitor of the kinase. In this paper, we discussed on modulation of
ADR
-resistance by KN-62.
...
PMID:Effect of KN-62, Ca2+/calmodulin-dependent protein kinase II inhibitor, on adriamycin resistance of human ovarian cancer cells. 748 93
