Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:2.7.11.13 (
protein kinase C
)
49,245
document(s) hit in 31,850,051 MEDLINE articles (0.03 seconds)
.
Concepts found in the documents ranked by [
Frequency
|
Pointwise Mutual Information
|
Symmetric Conditional Probability
] .
Human Gene/Protein
PKC
11365
Mol
4123
Sep
3589
ATP
2312
calmodulin
2287
insulin
2193
tyrosine kinase
2035
PKA
1595
AMP
1503
ERK1
1495
MAPK
1484
p38
1441
ERK
1359
threonine
1344
protein kinase C inhibitor
1220
cytokine
1165
TPA
1126
adenylate cyclase
1065
PKC-alpha
1019
phosphatase
996
angiotensin II
953
epidermal growth factor
919
MEK
914
thrombin
906
mitogen-activated protein
894
phosphatidylinositol 3-kinase
869
GTP
866
ATPase
820
extracellular signal-regulated kinase
818
phospholipase D
796
cAMP-dependent protein kinase
793
MAP kinase
785
PLC
783
c-fos
763
PI3K
697
collagen
690
phospholipase A2
671
tumor necrosis factor
666
Rho
659
JNK
650
adenylyl cyclase
642
AP-1
633
lipopolysaccharide
617
bradykinin
611
protein tyrosine kinase
559
caspase-3
555
nitric oxide synthase
546
endoplasmic reticulum
540
membrane-bound
538
Ang II
535
c-Jun
530
ADP
525
platelet-derived growth factor
513
protein phosphatase
512
cyclooxygenase
510
endothelin-1
494
vasopressin
475
alpha, beta
473
histone
468
phospholipase
452
TNF
444
fibronectin
420
CA1
409
polypeptide
404
myosin light chain
401
phosphoprotein
393
protein kinase inhibitor
393
calcineurin
392
RhoA
391
IL-2
390
p42
387
phosphodiesterase
382
epidermal growth factor receptor
378
PKC-beta
378
TNF-alpha
377
ras
377
PKC zeta
377
EGF receptor
376
EGF
374
myosin
369
more...
Disease
tumor
2938
cancer
2760
pertussis
1576
diabetes
1254
ischemia
915
leukemia
586
hypertension
577
Alzheimer's disease
546
neuroblastoma
531
carcinogenesis
509
hyperglycemia
504
breast cancer
484
cholera
475
atherosclerosis
451
depression
446
carcinoma
420
glioma
386
melanoma
353
hepatocellular carcinoma
341
MCF
329
HIV
325
SDS
287
tumorigenesis
286
type 2 diabetes
247
lymphoma
241
diabetic nephropathy
232
obesity
229
prostate cancer
228
tumor growth
223
heart failure
220
ATM
212
adenocarcinoma
204
tumor progression
192
colon cancer
190
immunodeficiency
186
stroke
182
Blocking
164
myocardial ischemia
155
asthma
152
pheochromocytoma
152
diabetic retinopathy
149
myocardial infarction
149
NAME
148
lung cancer
143
acute promyelocytic leukemia
140
cardiovascular disease
137
squamous cell carcinoma
132
metastases
130
astrocytoma
130
renal disease
127
PDD
125
sepsis
123
sepsis
122
GSH
120
Parkinson's disease
113
cerebral ischemia
109
glioblastoma
108
osteosarcoma
108
erythroleukemia
103
plaque
99
myeloid leukemia
98
Epstein
96
polycystic kidney
93
acute myeloid leukemia
93
rheumatoid arthritis
89
PDB
85
vascular disease
85
virus infection
83
lung carcinoma
82
bipolar disorder
81
cold
81
infectious diseases
80
colorectal cancer
80
cystic fibrosis
79
dementia
79
AIDS
79
gastric cancer
78
retinoblastoma
78
neuropathy
77
chronic lymphocytic leukemia
77
more...
Symptom
pain
515
seizures
104
starvation
89
functional recovery
67
analgesia
66
collapse
40
anesthesia
39
diarrhea
39
ataxia
35
rundown
29
hypothermia
27
myalgia
18
acute stress
17
hypercapnia
16
thinning
16
fatigue
16
acute pain
15
memory loss
14
exhaustion
14
spasm
13
respiratory distress
13
hyperoxia
13
anorexia
13
angina
12
weakness
12
vomiting
12
splenomegaly
10
cachexia
10
fasciculation
9
Anoxia
9
nausea
9
acidity
9
headache
8
skin damage
8
overweight
7
cerebellar ataxia
7
Neuropathic pain
7
erythema
7
dystonia
7
cough
7
HSA
6
chest pain
6
tremor
5
incoordination
5
flushing
4
twitching
4
discomfort
4
syncope
4
constipation
4
bitter taste
4
impaired motor coordination
4
discomfort
4
skin irritant
4
orofacial pain
4
ENT
3
cancer pain
3
muscle stiffness
3
paresthesia
3
myoclonus
3
bone pain
3
Spots
3
polyuria
3
despair
3
dyspnea
3
distraction
3
sleepiness
3
neuralgia
3
menopausal symptoms
3
abdominal pain
3
autodigestion
2
hepatosplenomegaly
2
numbness
2
neck pain
2
hepatomegaly
2
agitation
2
bradykinesia
2
dizziness
2
Scratch
2
rhinorrhea
2
rigors
2
more...
Drug
IL-2
393
MAP
297
Angiotensin II
267
Forskolin
263
ROS
247
Cardiovasc
231
IFN-gamma
231
Dermatol
213
lysine
205
caffeine
182
CSF
162
PTH
134
vitamin E
133
Histamine
127
Ethanol
125
Nephron
106
ETA
94
K-252a
83
CaCl2
80
ICI
80
CaCl2
80
CaCl2
80
Gel
78
Indomethacin
73
Asn
57
Ouabain
50
Phosphatidylserine
47
Retinoic acid
46
ascorbate
42
nitroglycerin
40
EE2
40
Glucagon
39
CAM
35
ADR
35
p75
35
Amiloride
34
Amiloride
34
Adriamycin
33
NADH
33
Vitamin E
33
IFN-beta
31
Heme
30
GHRP
26
Leaf
24
TAT
24
Taxol
23
CTX
23
Atropine
22
Growth hormone
22
Growth hormone
22
DNase I
22
uPA
21
Sodium nitroprusside
21
Trifluoperazine
20
Nitric Oxide
20
G-CSF
19
CCL
19
MRC
18
Activin
18
Imatinib
17
ABC
17
Alanine
17
ETS
16
ENT
16
EPA
15
Estrogens
14
GRF
13
Luteinizing
13
Quisqualate
13
Propofol
13
Monit
13
CDP
12
Vitamin A
12
Fructose
12
Arsenic trioxide
11
Gleevec
11
Gelatin
11
PCP
11
Portal
11
Adenosine triphosphate
11
more...
Enzyme
protein kinase C
49245
protein kinase
9214
mitogen-activated protein kinase
5579
phospholipase C
3614
ERK
1847
MEK
1390
adenylate cyclase
1115
calcineurin
999
phospholipase A2
901
thrombin
901
AMPK
884
phosphatidylinositol 3-kinase
872
ATPase
870
phospholipase D
796
focal adhesion kinase
772
NADPH oxidase
746
NADPH oxidase
680
CaMKII
540
luciferase
478
caspase-3
430
myosin light chain kinase
423
phosphodiesterase
384
phosphoinositide 3-kinase
333
PKG
310
catalase
301
superoxide dismutase
300
lipoxygenase
276
NO synthase
274
alkaline phosphatase
269
MAP
256
diacylglycerol kinase
228
trypsin
226
guanylate cyclase
214
protein phosphatase 2A
209
GSK
208
proteasome
199
glutathione S-transferase
197
AMP-activated protein kinase
195
cdc2
193
ornithine decarboxylase
189
collagenase
177
P-glycoprotein
174
renin
172
tyrosine hydroxylase
167
lactate dehydrogenase
166
urokinase-type plasminogen activator
138
PDK1
134
peroxidase
132
IKK
130
reverse transcriptase
129
PARP
122
chloramphenicol acetyltransferase
116
GRK5
113
aldose reductase
112
NOS
103
MEKK1
98
PI-PLC
94
lipase
91
lipoprotein lipase
87
AMPK
86
RNA polymerase
86
xanthine oxidase
85
acetylcholinesterase
84
topoisomerase
82
creatine kinase
81
caspase-8
80
glutathione peroxidase
78
GRK2
78
caspase-9
75
APC
69
topoisomerase
68
RNase
66
RNase
65
phosphorylase
62
acid phosphatase
60
sphingosine kinase
59
tissue plasminogen activator
55
transglutaminase
54
tyrosinase
52
MMP-3
52
more...
Compound
calcium
12612
acetate
9883
cAMP
3852
Dec
3745
DNA
3047
tyrosine
2958
serine
2549
ATP
2316
PMA
2213
PMA
2204
sodium
2161
glucose
2044
threonine
1849
oxygen
1795
phosphate
1713
AMP
1546
glutamate
1180
TPA
1126
TPA
1126
nitric oxide
1072
Phorbol
1059
glycerol
1050
Clin
927
alanine
887
GTP
871
cGMP
852
MEK
833
potassium
741
arginine
736
Phe
671
Staurosporine
599
Staurosporine
599
2-methylpiperazine
596
ADP
569
ethanol
548
water
538
ADP
528
ADP
527
leucine
481
cysteine
465
TNF
444
Insulin
427
sulfate
414
noradrenaline
397
Phorbol 12-myristate 13-acetate
378
hydrogen
375
GF 109203X
374
5-HT
365
GABA
361
GABA
355
lysine
348
Ang II
344
retinoic acid
344
H2O2
340
Cardiol
336
NMDA
329
methionine
329
COS
325
salt
311
PGE2
301
Angiotensin II
294
SDS
290
zinc
290
GDP
265
Forskolin
263
MAP
257
Mg2+
256
DAD
251
DAG
251
NH2
240
AMPA
238
prostacyclin
231
Thrombin
230
aldosterone
222
Asp
219
NADPH
204
NADPH
203
PGE
199
galactose
197
bromide
197
more...