Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:2.7.11.13 (protein kinase C)
 49,245 document(s) hit in 31,850,051 MEDLINE articles (0.04 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
PKC 11365
Mol 4123
Sep 3589
ATP 2312
calmodulin 2287
insulin 2193
tyrosine kinase 2035
PKA 1595
AMP 1503
ERK1 1495
MAPK 1484
p38 1441
ERK 1359
threonine 1344
protein kinase C inhibitor 1220
cytokine 1165
TPA 1126
adenylate cyclase 1065
PKC-alpha 1019
phosphatase 996
angiotensin II 953
epidermal growth factor 919
MEK 914
thrombin 906
mitogen-activated protein 894
phosphatidylinositol 3-kinase 869
GTP 866
ATPase 820
extracellular signal-regulated kinase 818
phospholipase D 796
cAMP-dependent protein kinase 793
MAP kinase 785
PLC 783
c-fos 763
PI3K 697
collagen 690
phospholipase A2 671
tumor necrosis factor 666
Rho 659
JNK 650
adenylyl cyclase 642
AP-1 633
lipopolysaccharide 617
bradykinin 611
protein tyrosine kinase 559
caspase-3 555
nitric oxide synthase 546
endoplasmic reticulum 540
membrane-bound 538
Ang II 535
c-Jun 530
ADP 525
platelet-derived growth factor 513
protein phosphatase 512
cyclooxygenase 510
endothelin-1 494
vasopressin 475
alpha, beta 473
histone 468
phospholipase 452
TNF 444
fibronectin 420
CA1 409
polypeptide 404
myosin light chain 401
protein kinase inhibitor 393
phosphoprotein 393
calcineurin 392
RhoA 391
IL-2 390
p42 387
phosphodiesterase 382
epidermal growth factor receptor 378
PKC-beta 378
ras 377
PKC zeta 377
TNF-alpha 377
EGF receptor 376
EGF 374
myosin 369
calcium channel 365
NMDA receptor 364
p53 356
GABA 353
IL-6 350
AKT 350
MEK1 350
Bcl-2 345
vascular endothelial growth factor 343
TGF-beta 334
phosphoinositide 3-kinase 333
myosin light chain kinase 325
p44 321
CD4 319
p21 319
Raf-1 318
phosphorylating 316
mTOR 315
G protein-coupled receptor 315
PKG 310
protein kinase B 309
p38 mitogen-activated protein kinase 308
metabotropic glutamate receptor 301
LPS 299
ERK2 298
insulin receptor 293
glycoprotein 292
nerve growth factor 290
SDS 286
amyloid precursor protein 284
c-myc 280
TCR 280
lipoxygenase 276
GTPase 271
muscarinic receptor 266
proximal tubule 263
substance P 262
GDP 260
p65 260
alkaline phosphatase 257
superoxide dismutase 257
beta 1 256
MAP 255
DAG 254
CaMKII 254
IL-1 251
bombesin 249
ROS 247
PI3 246
opioid receptor 244
membrane protein 244
CREB 243
IL-8 243
IFN-gamma 238
serine/threonine kinase 235
MARCKS 234
Gen 233
beta II 230
parathyroid hormone 227
GAP-43 227
interleukin-2 226
cholecystokinin 225
inducible nitric oxide synthase 224
c-Src 222
catalase 222
Rho kinase 220
PP1 220
receptor tyrosine kinase 219
IL-4 218
focal adhesion kinase 216
interleukin-6 214
PKB 210
T cell receptor 210
interferon 208
tumor necrosis factor alpha 208
proto-oncogene 207
ET-1 207
calpain 207
5-hydroxytryptamine 206
matrix metalloproteinase 206
more...
Disease
tumor 2938
cancer 2760
pertussis 1576
diabetes 1254
ischemia 915
leukemia 586
hypertension 577
Alzheimer's disease 546
neuroblastoma 531
carcinogenesis 509
hyperglycemia 504
breast cancer 484
cholera 475
atherosclerosis 451
depression 446
carcinoma 420
glioma 386
melanoma 353
hepatocellular carcinoma 341
MCF 329
HIV 325
SDS 287
tumorigenesis 286
type 2 diabetes 247
lymphoma 241
diabetic nephropathy 232
obesity 229
prostate cancer 228
tumor growth 223
heart failure 220
ATM 212
adenocarcinoma 204
tumor progression 192
colon cancer 190
immunodeficiency 186
stroke 182
Blocking 164
myocardial ischemia 155
pheochromocytoma 152
asthma 152
myocardial infarction 149
diabetic retinopathy 149
NAME 148
lung cancer 143
acute promyelocytic leukemia 140
cardiovascular disease 137
squamous cell carcinoma 132
metastases 130
astrocytoma 130
renal disease 127
PDD 125
sepsis 123
sepsis 122
GSH 120
Parkinson's disease 113
cerebral ischemia 109
glioblastoma 108
osteosarcoma 108
erythroleukemia 103
plaque 99
myeloid leukemia 98
Epstein 96
acute myeloid leukemia 93
polycystic kidney 93
rheumatoid arthritis 89
vascular disease 85
PDB 85
virus infection 83
lung carcinoma 82
bipolar disorder 81
cold 81
infectious diseases 80
colorectal cancer 80
AIDS 79
cystic fibrosis 79
dementia 79
retinoblastoma 78
gastric cancer 78
hyperinsulinemia 77
chronic lymphocytic leukemia 77
neuropathy 77
retinopathy 77
PHA 76
diabetic neuropathy 76
epilepsy 75
non-small cell lung cancer 74
Adhesion 72
ovarian cancer 71
pancreatic cancer 71
influenza 69
MLC 67
SEM 66
proteinuria 66
schizophrenia 65
PAF 63
tetanus 63
pulmonary hypertension 60
chronic pain 60
uterus 59
mole 58
chronic lymphocytic leukemia 58
skin tumor 58
chronic renal failure 58
Infection 57
psoriasis 57
multiple myeloma 57
blindness 57
addiction 57
glomerulosclerosis 56
acute lymphoblastic leukemia 56
arthritis 55
mole 55
Steroids 55
cognitive impairment 54
Mycobacterium 52
subarachnoid hemorrhage 51
Leukemia 51
skin cancer 51
sarcoma 49
B-cell lymphoma 49
fibrosarcoma 49
APC 49
NPC 49
type 1 diabetes 48
insulinoma 48
cardiomyopathy 47
LTD 46
coronary artery disease 46
cytomegalovirus 46
memory impairment 45
mammary tumor 45
hepatitis B 45
chronic myeloid leukemia 43
tuberculosis 43
heart disease 43
peripheral neuropathy 42
Melanoma 42
metabolic syndrome 42
neoplastic transformation 41
choriocarcinoma 41
systemic lupus erythematosus 41
renal failure 41
dyslipidemia 40
inflammatory bowel disease 40
CEM 39
congestive heart failure 39
Evans 39
diabetic cardiomyopathy 39
adenoma 39
multiple sclerosis 39
hyperlipidemia 38
fatty liver 38
glucose intolerance 38
essential hypertension 38
suicide 37
AGS 37
SCH 37
amyotrophic lateral sclerosis 37
herpes simplex 37
pituitary tumor 36
more...
Symptom
pain 515
seizures 104
starvation 89
functional recovery 67
analgesia 66
collapse 40
diarrhea 39
anesthesia 39
ataxia 35
rundown 29
hypothermia 27
myalgia 18
acute stress 17
thinning 16
hypercapnia 16
fatigue 16
acute pain 15
exhaustion 14
memory loss 14
spasm 13
respiratory distress 13
hyperoxia 13
anorexia 13
angina 12
weakness 12
vomiting 12
splenomegaly 10
cachexia 10
acidity 9
nausea 9
Anoxia 9
fasciculation 9
headache 8
skin damage 8
overweight 7
cough 7
dystonia 7
Neuropathic pain 7
erythema 7
cerebellar ataxia 7
chest pain 6
HSA 6
incoordination 5
tremor 5
orofacial pain 4
syncope 4
constipation 4
skin irritant 4
impaired motor coordination 4
bitter taste 4
discomfort 4
discomfort 4
flushing 4
twitching 4
ENT 3
muscle stiffness 3
paresthesia 3
myoclonus 3
polyuria 3
sleepiness 3
despair 3
dyspnea 3
distraction 3
Spots 3
bone pain 3
neuralgia 3
abdominal pain 3
menopausal symptoms 3
cancer pain 3
autodigestion 2
agitation 2
dizziness 2
rhinorrhea 2
numbness 2
bradykinesia 2
Scratch 2
low back pain 2
skin irritation 2
hepatomegaly 2
hepatosplenomegaly 2
neck pain 2
rigors 2
wheezing 2
general problem 1
hypocapnia 1
forgetfulness 1
eye pain 1
urinary frequency 1
colic 1
generalized pain 1
polydipsia 1
bloating 1
scaly skin 1
Inflammatory pain 1
paraparesis 1
Mechanical pain 1
Excitable 1
photophobia 1
chorea 1
Gastrointestinal symptoms 1
ophthalmoplegia 1
pelvic pain 1
Decreased activity 1
anosmia 1
lassitude 1
tonic-clonic seizure 1
loss of balance 1
chronic cough 1
Excitability 1
arthralgia 1
DNA marker 1
torticollis 1
tachypnea 1
muscle rigidity 1
hopelessness 1
asthenia 1
Ill 1
female puberty 1
insomnia 1
Fluctuation 1
right upper quadrant pain 1
tonic seizure 1
dry eye 1
Stepping 1
athetosis 1
abnormal gait 1
disturbed balance 1
back pain 1
tingling 1
ACHE 1
vertigo 1
masculinization 1
Crawling 1
stump pain 1
Noise-induced hearing loss 1
heartburn 1
asynergy 1
Hyperekplexia 1
hypotonia 1
spasticity 1
eds 1
hot flashes 1
hunger 1
Drug
IL-2 393
MAP 297
Angiotensin II 267
Forskolin 263
ROS 247
Cardiovasc 231
IFN-gamma 231
Dermatol 213
lysine 205
caffeine 182
CSF 162
PTH 134
vitamin E 133
Histamine 127
Ethanol 125
Nephron 106
ETA 94
K-252a 83
CaCl2 80
CaCl2 80
ICI 80
CaCl2 80
Gel 78
Indomethacin 73
Asn 57
Ouabain 50
Phosphatidylserine 47
Retinoic acid 46
ascorbate 42
nitroglycerin 40
EE2 40
Glucagon 39
p75 35
CAM 35
ADR 35
Amiloride 34
Amiloride 34
Vitamin E 33
Adriamycin 33
NADH 33
IFN-beta 31
Heme 30
GHRP 26
Leaf 24
TAT 24
CTX 23
Taxol 23
DNase I 22
Growth hormone 22
Growth hormone 22
Atropine 22
Sodium nitroprusside 21
uPA 21
Trifluoperazine 20
Nitric Oxide 20
G-CSF 19
CCL 19
MRC 18
Activin 18
Imatinib 17
ABC 17
Alanine 17
ETS 16
ENT 16
EPA 15
Estrogens 14
Quisqualate 13
Monit 13
Propofol 13
Luteinizing 13
GRF 13
Vitamin A 12
CDP 12
Fructose 12
Arsenic trioxide 11
Gleevec 11
Albumin 11
Tocopherol 11
Adenosine triphosphate 11
Spiegel 11
NBT 11
PCP 11
Portal 11
Gelatin 11
Lovastatin 10
lactose 10
niacin 10
GEO 10
Ringer's solution 10
AC2 10
Safingol 10
IL-11 10
Glutathione 10
Etoposide 10
Asthma 9
linolenate 9
TAK 9
-deoxyadenosine 9
DM1 9
TTC 9
CoCl2 9
CoCl2 9
Nephron 9
Rolipram 9
G418 9
ALA 8
NAG 8
Troglitazone 8
Dial 8
HCH 8
Rasagiline 8
Fluorescein 8
Gefitinib 8
Secretin 8
Spectrum 7
IL-1ra 7
ZnCl2 7
AZT 7
AZT 7
CTX 7
Emodin 7
ROC 7
Clonidine 7
Simvastatin 7
Iloprost 7
Gabapentin 7
Phentolamine 7
Glycyrrhiza 7
Palmitoyl 7
ZnCl2 7
CTX 7
Emodin 7
Glycerol 7
Mutagen 6
Flavopiridol 6
balanced salt solution 6
TiO2 6
Azilect 6
Meth 6
Butaprost 6
Miltefosine 6
Balanol 6
Fluorescein 6
Methylene blue 6
pyridoxal phosphate 6
Bumetanide 6
DHT 6
Rosiglitazone 6
DEX 6
Pravastatin 6
Ginseng 6
DHT 6
R1881 5
Dithranol 5
CTC 5
Auranofin 5
Parkin 5
Cremophor EL 5
Bortezomib 5
Cetuximab 5
more...
Enzyme
protein kinase C 49245
protein kinase 9214
mitogen-activated protein kinase 5579
phospholipase C 3614
ERK 1847
MEK 1390
adenylate cyclase 1115
calcineurin 999
thrombin 901
phospholipase A2 901
AMPK 884
phosphatidylinositol 3-kinase 872
ATPase 870
phospholipase D 796
focal adhesion kinase 772
NADPH oxidase 746
NADPH oxidase 680
CaMKII 540
luciferase 478
caspase-3 430
myosin light chain kinase 423
phosphodiesterase 384
phosphoinositide 3-kinase 333
PKG 310
catalase 301
superoxide dismutase 300
lipoxygenase 276
NO synthase 274
alkaline phosphatase 269
MAP 256
diacylglycerol kinase 228
trypsin 226
guanylate cyclase 214
protein phosphatase 2A 209
GSK 208
proteasome 199
glutathione S-transferase 197
AMP-activated protein kinase 195
cdc2 193
ornithine decarboxylase 189
collagenase 177
P-glycoprotein 174
renin 172
tyrosine hydroxylase 167
lactate dehydrogenase 166
urokinase-type plasminogen activator 138
PDK1 134
peroxidase 132
IKK 130
reverse transcriptase 129
PARP 122
chloramphenicol acetyltransferase 116
GRK5 113
aldose reductase 112
NOS 103
MEKK1 98
PI-PLC 94
lipase 91
lipoprotein lipase 87
AMPK 86
RNA polymerase 86
xanthine oxidase 85
acetylcholinesterase 84
topoisomerase 82
creatine kinase 81
caspase-8 80
glutathione peroxidase 78
GRK2 78
caspase-9 75
APC 69
topoisomerase 68
RNase 66
RNase 65
phosphorylase 62
acid phosphatase 60
sphingosine kinase 59
tissue plasminogen activator 55
transglutaminase 54
tyrosinase 52
CPT 52
ACE 52
MMP-3 52
plasmin 51
PDE 50
lysozyme 49
choline acetyltransferase 49
CPT 48
MMP 43
CPT 43
hexosaminidase 43
PTPase 40
elastase 40
transcriptase 40
phosphorylase kinase 39
glutamine synthetase 38
aequorin 37
neutral sphingomyelinase 37
apyrase 37
beta-galactosidase 36
adenosine deaminase 36
NQO1 36
CD10 36
adenosine deaminase 35
phosphatidylinositol 4-kinase 34
thymidine kinase 34
heme oxygenase 33
12-lipoxygenase 31
phosphoenolpyruvate carboxykinase 31
ACS 30
complex I 30
endonuclease 30
glyceraldehyde-3-phosphate dehydrogenase 29
alanine aminotransferase 28
glyceraldehyde-3-phosphate dehydrogenase 28
chymotrypsin 27
cholinesterase 27
monoamine oxidase 27
DNA polymerase 26
matrix metalloproteinase 2 26
neutrophil elastase 26
MIP 26
matrix metalloproteinase 9 25
beta-glucuronidase 25
phosphoenolpyruvate carboxykinase 25
ATP synthase 24
TACE 24
TAT 24
HSD 24
hormone-sensitive lipase 24
phosphoenolpyruvate carboxykinase 24
m-calpain 23
gamma-glutamyl transpeptidase 22
TOR 22
rhodopsin kinase 22
glyceraldehyde-3-phosphate dehydrogenase 22
interstitial collagenase 22
furin 21
aspartate aminotransferase 21
pyruvate kinase 21
15-lipoxygenase 21
calcium pump 21
glyceraldehyde-3-phosphate dehydrogenase 21
p80 21
histidine decarboxylase 21
beta-secretase 21
glyceraldehyde-3-phosphate dehydrogenase 21
hexokinase 21
glutathione reductase 20
AMP-activated kinase 20
ribonuclease 20
aldehyde dehydrogenase 20
cathepsin G 20
mu-calpain 20
MDR 20
ribonuclease 20
pyruvate dehydrogenase 19
prostaglandin synthetase 19
caspase-1 19
cellulose synthase 18
pyruvate dehydrogenase 17
more...
Compound
calcium 12612
acetate 9883
cAMP 3852
Dec 3745
DNA 3047
tyrosine 2958
serine 2549
ATP 2316
PMA 2213
PMA 2204
sodium 2161
glucose 2044
threonine 1849
oxygen 1795
phosphate 1713
AMP 1546
glutamate 1180
TPA 1126
TPA 1126
nitric oxide 1072
Phorbol 1059
glycerol 1050
Clin 927
alanine 887
GTP 871
cGMP 852
MEK 833
potassium 741
arginine 736
Phe 671
Staurosporine 599
Staurosporine 599
2-methylpiperazine 596
ADP 569
ethanol 548
water 538
ADP 528
ADP 527
leucine 481
cysteine 465
TNF 444
Insulin 427
sulfate 414
noradrenaline 397
Phorbol 12-myristate 13-acetate 378
hydrogen 375
GF 109203X 374
5-HT 365
GABA 361
GABA 355
lysine 348
Ang II 344
retinoic acid 344
H2O2 340
Cardiol 336
NMDA 329
methionine 329
COS 325
salt 311
PGE2 301
Angiotensin II 294
zinc 290
SDS 290
GDP 265
Forskolin 263
MAP 257
Mg2+ 256
DAG 251
DAD 251
NH2 240
AMPA 238
prostacyclin 231
Thrombin 230
aldosterone 222
Asp 219
NADPH 204
NADPH 203
PGE 199
galactose 197
bromide 197
THP 194
THP 194
UTP 187
diacetate 185
Triton X-100 185
Carbachol 184
Sphingosine 184
caffeine 182
ACh 177
Gly 173
DEAE 172
Arachidonic acid 168
Genistein 163
ACTH 161
manganese 160
Rottlerin 158
Rottlerin 158
Rottlerin 158
isoquinoline 155
MDA 152
Chelerythrine 148
Chelerythrine 148
prostaglandin E1 144
iodine 144
Adenosine 143
gamma-aminobutyric acid 141
N-acetylcysteine 139
piperazine 137
phosphoserine 137
tryptophan 137
Phosphatidylinositol 136
Tyrosine 133
Glutamate 132
Wortmannin 129
MTT 127
Histamine 127
vitamin D 127
Dopamine 126
cadmium 126
GSH 125
Ins(1,4,5)P3 125
GSH 125
TMB 123
iron 123
Bradykinin 119
Okadaic acid 119
PLA 111
EDTA 109
PEG 109
EDTA 109
GMP 108
nitrogen 106
palmitic acid 106
nicotinamide 106
proline 105
His 101
TSH 101
DMSO 99
Serine 99
myristic acid 99
ETA 98
TRH 96
Cycloheximide 94
Norepinephrine 94
ammonium 93
urea 93
aspartic acid 92
fMet 92
superoxide radical 89
myristic acid 89
Dexamethasone 87
CO2 86
glutamine 85
PEG 85
PDB 84
carbonate 84
NAD 82
CAT 82
CAT 82
CAT 82
more...