Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:2.7.11.13 (
protein kinase C
)
49,245
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
One of
protein kinase C
(
PKC
) isozymes,
PKC
beta binds to receptor for activated C kinase 1 (RACK1), and their complex is suggested to be translocated to melanosomes. The binding site of
PKC
beta for RACK1 is considered one of its catalytic domains, V5 domain which consists of three motifs such as V5-1,
V5-2
, and V5-3. Among these, V5-1 region, extreme C-terminal residues of
PKC
beta showed the highest RACK1-binding affinity.
PKC
beta can be classified into
PKC
betaI and
PKC
betaII based on their different V5 domains. RACK1-binding affinity of
PKC
betaII is five times greater than that of
PKC
betaI. The structures of
PKC
betaI,
PKC
betaII, and RACK1 are not known. However, the conformational study on
PKC
betaII V5-1 region showing high RACK1-binding selectivity may help us in understanding the interaction between RACK1 and
PKC
betaII.
...
PMID:Conformational analysis in solution of protein kinase C betaII V5-1 peptide. 1618 52
