Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:2.7.11.13 (
protein kinase C
)
49,245
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Heat shock treatment of rat embryo fibroblasts resulted in a 60% increase in cytosolic
protein kinase C
activity, in contrast to phorbol ester-induced translocation to the membrane. During reversal of the cells back to the normal temperature a decrease in cytosolic
PKC
activity was observed and paralleled by an increase in protamine kinase activity. Cell lysates prepared from heat shock-treated cells show a marked calcium/phospholipid-dependent phosphorylation of several endogenous
PKC
substrate proteins, while the 28-kDa stress protein was shown to be a
PKC
substrate. These cells express the
TYPE
III-alpha isoform of
PKC
and, thus, the alterations induced within cells exposed to hyperthermic treatment may reflect a functional significance with regard to the regulation of this specific isoform.
...
PMID:Alterations in protein kinase C type III-alpha during heat shock of rat embryo fibroblasts. 184 15
