Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:2.7.11.13 (
protein kinase C
)
49,245
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Long-term potentiation (LTP) is the persistent facilitation of synaptic responses induced by a brief tetanic stimulation (tetanus). From our observations and the findings of others, we hereby propose a novel hypothesis of the cellular mechanisms involved in the induction of hippocampal LTP. Quisqualate receptors are first activated during
tetany
and this stimulates the turnover of phosphatidyl inositol (Pl). The increased turnover activates
protein kinase C
and this results in the induction of LTP. The influx of Ca++ through N-methyl-D-aspartate-linked receptor mechanisms may participate in this process but is not the main factor for the activation of
protein kinase C
. With this hypothesis, the role of quisqualate receptors associated with the turnover of Pl is emphasized, and its relevance is discussed to the input specificity of LTP and to the modulation of LTP by certain drugs.
...
PMID:The role of quisqualate receptors in the induction of hippocampal long-term potentiation. 217 81
