EC:2.7.11.12 - FACTA Search

Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts: Target Concepts:

Query: EC:2.7.11.12 (PKG)
2,515 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

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Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .

Human Gene/Protein
PKG	2515
cAMP-dependent protein kinase	302
PKA	298
guanylate cyclase	289
phosphodiesterase	231
nitric oxide synthase	221
Mol	215
Sep	179
ATP	173
soluble guanylyl cyclase	171
guanylyl cyclase	164
PKC	161
calmodulin	110
vasodilator-stimulated phosphoprotein	89
atrial natriuretic peptide	80
MAPK	78
threonine	72
phosphatase	70
ATPase	65
natriuretic peptide	63
AMP	62
eNOS	57
PDE5	56
neuronal nitric oxide synthase	54
ERK1	53
C-type natriuretic peptide	53
ERK	48
insulin	48
p38	46
PDE	45
RhoA	45
inducible nitric oxide synthase	43
angiotensin II	38
myosin light chain	37
collagen	37
ADP	36
PI3K	36
tyrosine kinase	36
protein kinase inhibitor	36
Rho	36
thrombin	35
atrial natriuretic factor	33
myosin	33
VASP	32
phosphoprotein	31
adenylyl cyclase	30
protein phosphatase	30
SNAP	29
CREB	29
dimeric	29
endothelial nitric oxide synthase	29
endoplasmic reticulum	28
adenylate cyclase	27
membrane-bound	27
myosin light chain kinase	27
phospholamban	27
CPT	26
polypeptide	26
leucine zipper	26
Bcl-2	25
ANP	25
endothelin-1	25
phosphorylating	24
Ang II	24
CA1	24
caspase-3	24
cGMP phosphodiesterase	24
phosphatidylinositol 3-kinase	24
Rho kinase	24
MEK	23
olfactory	22
NPR-A	21
Phosphodiesterase	21
GTP	21
cytokine	21
SIN	21
histone	20
MYPT1	20
calcineurin	20
PKI	20

Disease
NAME	100
hypertension	79
cancer	77
heart failure	63
ischemia	63
tumor	60
PDE	45
depression	44
diabetes	37
malaria	33
atherosclerosis	31
pertussis	27
erectile dysfunction	25
Alzheimer's disease	24
pulmonary hypertension	24
obesity	22
stroke	21
SDS	20
colon cancer	16
neuroblastoma	16
myocardial infarction	15
gastric cancer	15
sepsis	15
sepsis	15
myocardial ischemia	13
vascular disease	13
hyperglycemia	12
type 2 diabetes	12
breast cancer	12
asthma	11
congestive heart failure	10
glioma	10
MLC	9
heart disease	9
colorectal cancer	9
ATM	8
AGS	8
GSH	8
cardiovascular disease	8
uterus	8
diabetic nephropathy	8
cholera	7
tumor growth	7
LTD	7
cold	7
tetanus	7
carcinoma	6
MCF	6
tumor progression	6
anemia	6
tumorigenesis	6
Parkinson's disease	6
coccidiosis	5
acute myocardial infarction	5
mole	5
memory impairment	5
mole	5
cerebral ischemia	5
melanoma	5
HIV	5
pheochromocytoma	5
adenocarcinoma	5
carcinogenesis	5
plaque	5
tularemia	5
Frey	5
thalassemia	5
metabolic syndrome	5
sickle cell disease	5
Blocking	5
FAS	5
immunodeficiency	4
Wilson's disease	4
amnesia	4
iron deficiency	4
chronic obstructive pulmonary disease	4
lung cancer	4
SEM	4
leukemia	4
AS1	4

Symptom
pain	40
diarrhea	8
collapse	6
angina	6
functional recovery	3
acute pain	3
seizures	2
hypercapnia	2
spasm	2
anesthesia	2
dystonia	2
overweight	1
bradykinesia	1
cerebellar ataxia	1
analgesia	1
hypotonia	1
nausea and vomiting	1
Lower urinary tract symptoms	1
orofacial pain	1
hepatomegaly	1
clumsiness	1
anorexia	1
Anoxia	1
Noise-induced hearing loss	1
splenomegaly	1
rundown	1
arthralgia	1
cough	1
cachexia	1
starvation	1
fatigue	1
constipation	1
respiratory distress	1
vomiting	1
memory loss	1
myoclonus	1
hemiplegia	1

Enzyme
PKG	2515
protein kinase	2085
guanylate cyclase	453
AMPK	319
protein kinase C	310
phosphodiesterase	231
mitogen-activated protein kinase	181
NO synthase	143
NOS	77
ATPase	65
ERK	60
calcineurin	59
PDE	58
CaMKII	39
myosin light chain kinase	36
phospholipase C	35
thrombin	34
protein phosphatase 2A	34
MEK	32
adenylate cyclase	30
CPT	27
CPT	26
focal adhesion kinase	26
CPT	26
AMP-activated protein kinase	24
phosphatidylinositol 3-kinase	24
superoxide dismutase	22
caspase-3	21
luciferase	19
AMPK	17
cGMP phosphodiesterase	17
trypsin	16
catalase	15
NADPH oxidase	14
alkaline phosphatase	14
proteasome	13
NADPH oxidase	12
GSK	12
peroxidase	11
renin	10
heme oxygenase	10
PDK1	9
glutathione S-transferase	8
cdc2	8
PARP	7
glucose-6-phosphate dehydrogenase	7
phosphorylase kinase	7
ACS	6
hormone-sensitive lipase	6
MAP	6
MPP	6
RNA polymerase	5
5'-nucleotidase	5
tyrosine hydroxylase	5
lactate dehydrogenase	5
arginase	5
phosphoglycerate kinase	5
tyrosinase	5
aldehyde dehydrogenase	5
NADPH-diaphorase	4
complex I	4
succinate dehydrogenase	4
phospholipase D	4
phosphoinositide 3-kinase	4
aldehyde dehydrogenase	4
aldehyde dehydrogenase	4
aldehyde dehydrogenase	4
GRK5	4
aldehyde dehydrogenase	4
ACE	4
transcriptase	3
ADP-ribosyltransferase	3
acetyl-CoA carboxylase	3
APC	3
alanine aminotransferase	3
reverse transcriptase	3
ADP-ribosyltransferase	3
phosphoribulokinase	3
PI-PLC	3
chloramphenicol acetyltransferase	3