Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts: Gene/Protein Disease Symptom Drug Enzyme Compound   Target Concepts: Gene/Protein Disease Symptom Drug Enzyme Compound

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Query: EC:2.7.11.12 (PKG)
2,515 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .

Human Gene/Protein PKG 2515 cAMP-dependent protein kinase 302 PKA 298 guanylate cyclase 289 phosphodiesterase 231 nitric oxide synthase 221 Mol 215 Sep 179 ATP 173 soluble guanylyl cyclase 171 guanylyl cyclase 164 PKC 161 calmodulin 110 vasodilator-stimulated phosphoprotein 89 atrial natriuretic peptide 80 MAPK 78 threonine 72 phosphatase 70 ATPase 65 natriuretic peptide 63 AMP 62 eNOS 57 PDE5 56 neuronal nitric oxide synthase 54 ERK1 53 C-type natriuretic peptide 53 ERK 48 insulin 48 p38 46 RhoA 45 PDE 45 inducible nitric oxide synthase 43 angiotensin II 38 collagen 37 myosin light chain 37 protein kinase inhibitor 36 tyrosine kinase 36 PI3K 36 Rho 36 ADP 36 thrombin 35 atrial natriuretic factor 33 myosin 33 VASP 32 phosphoprotein 31 adenylyl cyclase 30 protein phosphatase 30 CREB 29 SNAP 29 endothelial nitric oxide synthase 29 dimeric 29 endoplasmic reticulum 28 adenylate cyclase 27 myosin light chain kinase 27 membrane-bound 27 phospholamban 27 leucine zipper 26 CPT 26 polypeptide 26 ANP 25 Bcl-2 25 endothelin-1 25 Ang II 24 caspase-3 24 Rho kinase 24 phosphorylating 24 phosphatidylinositol 3-kinase 24 cGMP phosphodiesterase 24 CA1 24 MEK 23 olfactory 22 SIN 21 cytokine 21 GTP 21 NPR-A 21 Phosphodiesterase 21 calcineurin 20 SDS 20 PKI 20 histone 20 MYPT1 20 superoxide dismutase 19 GTPase 19 extracellular signal-regulated kinase 19 TNF 19 AKT 18 tumor necrosis factor 18 PLC 18 lipopolysaccharide 18 ryanodine receptor 17 hemoglobin 17 collecting duct 17 AMPK 17 cGKI 17 CaMKII 17 PDE2 17 NPR-B 17 NMDA receptor 17 GMP 17 PKG1 17 bradykinin 16 heme oxygenase-1 16 thioredoxin 16 Mem 16 axonal 15 TNF-alpha 15 HEK 15 BK channel 15 GABA 15 ROS 15 epidermal growth factor receptor 15 LPS 15 mTOR 14 epidermal growth factor 14 brain-derived neurotrophic factor 14 catalase 14 BNP 14 alkaline phosphatase 14 mitogen-activated protein 14 cyclooxygenase 13 proteasome 13 cyclic nucleotide phosphodiesterase 13 Gen 13 JNK 13 PKB 13 DAF 13 catenin 13 platelet-derived growth factor 13 ionotropic 12 PRKG1 12 calpain 12 cGKII 12 cardiac muscle 12 casein kinase 12 L-type calcium channel 12 IL-6 12 c-fos 11 cystic fibrosis transmembrane conductance regulator 11 MAP kinase 11 EGF 11 ERK2 11 Protein kinase 11 GSK 11 proximal tubule 11 p21 11 AP-1 11 CNP 11 ANG 11 TGF-beta 11 NMR 11 5-hydroxytryptamine 11 G-substrate 11 p44 11 c-Jun 10 PDE4 10 titin 10 TRPC6 10 casein 10 NOS1 10 spermatozoa 10 albumin 10 vascular endothelium 10 p53 10 AMP-activated protein kinase 10 renin 10 glucagon 10 SOD 9 p42 9 calcitonin 9 gut 9 calcium channel 9 ubiquitin 9 NOS3 9 brush border 9 vasopressin 9 MLC 9 fused 9 inhibitor 2 9 fibronectin 9 protein kinase C inhibitor 9 cAMP-response element 9 vimentin 8 oxytocin 8 calponin 8 NPR-C 8 phosphodiesterase 5A 8 AGS 8 small GTPase 8 PP1 8 p65 8 substance P 8 NADPH 8 myosin heavy chain 8 protein S 8 A-I 8 GSH 8 MnSOD 8 PDGF 8 vasoactive intestinal peptide 8 guanylin 8 microsomal 7 kit 7 IRAG 7 glucose-6-phosphate dehydrogenase 7 IL-8 7 cytochrome c 7 GDP 7 matrix metalloproteinase 7 fibrinogen 7 cyclin D1 7 peroxisome proliferator-activated receptor 7 reductase 7 histone H2B 7 NOC 7 HO-1 7 STAT3 7 interacting protein 7 ET-1 7 vascular endothelial growth factor 7 insulin receptor 7 CNB 7 serine/threonine protein kinase 7 APB 7 p38 mitogen-activated protein kinase 7 CK2 7 PDK1 7 EGF receptor 6 glutamate receptor 6 VEGF 6 survivin 6 Raf-1 6 PI3 6 PP2A 6 RGS2 6 alpha-actin 6 fimbrin 6 cGMP-PDE 6 membrane protein 6 erythropoietin 6 osteopontin 6 tyrosine hydroxylase 6 ACS 6 guanylyl cyclase C 6 muscarinic receptor 6 calmodulin-dependent protein kinase IV 6 Myosin 6 protein kinase B 6 natriuretic peptide receptor B 6 MAP 6 amyloid precursor protein 6 Ca2+-ATPase 6 calcium/calmodulin-dependent protein kinase II 6 beta-catenin 6 PDE5A 6 serotonin transporter 6 GTPase-activating protein 6 heat shock protein 6 opioid receptor 6 thrombospondin 6 natriuretic peptide receptor A 6 protein tyrosine kinase 6 MPP 6 cAMP response element binding protein 6 hormone-sensitive lipase 6 vasoactive intestinal peptide (VIP) 6 AT1 6 elastin 5 CPI-17 5 LATS 5 cyclin 5 serum albumin 5 TRPC3 5 lactate dehydrogenase 5 CGI 5 synaptophysin 5 serine/threonine kinase 5 RyR2 5 SGK 5 metabotropic glutamate receptor 5 IL-4 5 Kir6.2 5 protein tyrosine phosphatase 5 P2X 5 NOS2 5 tyrosinase 5 CCK 5 cytochrome 5 S6K1 5 annexin V 5 telokin 5 sodium pump 5 p27 5 erythroid 5 MEK1 5 glutathione S-transferase 5 desmoglein 1 5 beta 1 5 Titin 5 protein phosphatase-1 5 p50 5 peroxisome proliferator-activated receptor gamma 5 NAD 5 Aplysia 5 myeloperoxidase 5 CaM kinase II 5 cage 5 occludin 5 P-selectin 5 p38 MAP kinase 5 phospholipase 5 caveolin-1 5 Met 5 IL-10 5 AT2 4 Dictyostelium 4 NADH 4 AS1 4 Cx43 4 SMC 4 epididymal 4 PP2 4 septin 4 caspase-9 4 growth hormone 4 PARP 4 extracellular signal regulated kinase 4 DARPP-32 4 adaptor protein 4 STAT 4 guanine nucleotide exchange factor 4 cAMP response element-binding protein 4 TAZ 4 actin-binding protein 4 IL-1 4 TRPV1 4 acid sphingomyelinase 4 phosphoinositide 3-kinase 4 P2Y12 4 TRPA1 4 MMP-2 4 TRPC4 4 UTR 4 chemokine 4 uroguanylin 4 von Willebrand factor 4 TLR4 4 cholecystokinin 4 NCX 4 platelet-derived 4 AVP 4 serum response factor 4 CNGA3 4 somatostatin 4 inward rectifier 4 Sp1 4 GMPS 4 PDE1A 4 IL-1 beta 4 G protein-coupled receptor 4 PPAR 4 EBP 4 mucin 4 NHE1 4 CCK8 4 proliferating cell nuclear antigen 4 perilipin 4 GUCY2D 4 SUR1 4 colon carcinoma 4 thyroid hormone 4 amylase 4 IL-17 4 osteogenic 4 MLCK 4 peroxidase 4 Vascular endothelial growth factor 4 parathyroid hormone 4 AAG 4 chloride channel 4 cAMP-dependent protein kinase catalytic subunit 4 IGF-1 4 TRAM 4 Hsp20 4 COX 4 DG2 4 extracellular matrix protein 4 phospholipase D 4 leptin 4 NDR 4 connexin 4 thrombin receptor 4 IFN-gamma 4 D. melanogaster 4 serine protease 4 COX-1 4 JAK2 4 GABA(A) receptor 4 glial fibrillary acidic protein 4 aldehyde dehydrogenase 4 alpha isoform 4 G protein-coupled receptor kinase 4 VIP 4 cyclin E 4 alpha, beta 4 brain-derived 4 histone deacetylase 3 PKR 3 ENaC 3 lectin 3 glucose transporter 3 14-3-3 3 tyrosine phosphatase 3 ORF 3 PKC-alpha 3 bcl-2 3 CD14 3 PKN 3 LKB1 3 ADRB2 3 TRPC1 3 natriuretic peptide clearance receptor 3 Aurora-A 3 CD11b 3 myosin phosphatase target subunit 1 3 extracellular signal-regulated kinase 1 3 CCD 3 cyclin-dependent kinase 3 beta-endorphin 3 MHC 3 myelin basic protein 3 amyloid beta 3 glycoprotein 3 Endothelin-1 3 CA3 3 GKAP42 3 G-septin 3 RSK 3 semaphorin 3A 3 urocortin 3 PIF 3 LATS1 3 tap 3 TRPV4 3 PNP 3 GLUT4 3 35 kDa 3 NAC 3 NR2B 3 adenyl cyclase 3 GST 3 ROCK1 3 transforming growth factor-beta 3 ADP-ribosyl cyclase 3 VEGFR2 3 connexin 43 3 Leydig cell 3 Pol 3 N-cadherin 3 asymmetrical 3 TCF 3 muscle specific 3 vascular cell adhesion molecule-1 3 fur 3 regulator of G protein signaling 3 RGS 3 glycogen synthase kinase 3 3 matrix protein 3 GT1 3 troponin I 3 GAF 3 nuclear factor of activated T-cells 3 IK1 3 SCH 3 PDE1C 3 agrin 3 xanthine oxidase 3 neutral endopeptidase 3 p38MAPK 3 thrombospondin 1 3 transcriptional regulator 3 Nrf2 3 PP2C 3 CgA 3 GTP-binding protein 3 Superoxide dismutase 3 adenomatous polyposis coli 3 GKAP 3 SOD2 3 RAGE 3 interleukin 2 3 osteosarcoma 3 smooth muscle myosin light chain kinase 3 HO-2 3 lysozyme 3 small G protein 3 CFTR 3 creatine kinase 3 cryptic 3 ribosomal S6 kinase 3 sonic hedgehog 3 MAST 3 ROCK2 3 ADP-ribosyltransferase 3 NHE3 3 TASK-1 3 TOF 3 ribosomal protein 3 c-Src 3 BRL 3 phosphorylase kinase 3 PDE4A 3 NGF 3 ACE 3 Proteasome 3 CB2 3 LDH 3 collagenase 3 nerve growth factor 3 pleckstrin 3 PRK 3 estrogen receptor 3 ESI 3 chromogranin A 3 acetyl-CoA carboxylase 3 YAP 3 ANF 3 cofilin 3 ASK1 3 AT1R 3 adrenomedullin 3 HO2 3 caspase-8 3 A431 3 PGK 3 A-kinase anchoring protein 3 VIII 3 CHOP 3 cyclooxygenase-1 3 smooth muscle myosin heavy chain 3 SCN 3 follicle-stimulating hormone 3 MMP-9 3 NHERF1 3 zyxin 2 short form 2 PAF receptor 2 CGKII 2 protease-activated receptor-1 2 interferon 2 PI3-kinase 2 holocarboxylase synthetase 2 cytochrome P450 2 monocyte chemoattractant protein-1 2 DRG 2 uncoupling protein 2 IFN 2 COX-2 2 smooth muscle alpha-actin 2 alanine aminotransferase 2 muscle protein 2 precursor protein 2 CXCR4 2 p21-activated kinase 1 2 aspartate aminotransferase 2 IL-33 2 Brain-derived neurotrophic factor 2 TFII-I 2 NPR 2 ET-3 2 PI-PLC 2 P40 2 Tyrosine kinase 2 PC6 2 p21-activated kinase 2 2 anti-apoptotic protein 2 TPA 2 thymus 2 CD36 2 BRAF 2 receptor tyrosine kinase 2 EPAC 2 sarcomeric 2 NADP 2 nitric oxide synthase 1 2 PKM 2 NHE2 2 GAPDH 2 ankyrin 2 glycoprotein IIb 2 activin 2 smoothelin-like 1 2 MSK 2 JNK1 2 San 2 pyruvate kinase 2 P2Y1 2 Vimentin 2 GLUT1 2 SGK494 2 hormone receptor 2 CRIK 2 G6PD 2 AKAP 2 phosphotyrosine phosphatase 2 glucose-6-phosphatase 2 cyclin-dependent kinase 4 2 CD38 2 G-protein-coupled receptor 2 unknown function 2 GRK2 2 POG 2 contractile protein 2 PDE2A 2 smoothelin 2 granulocyte 2 ATF-1 2 focal adhesion kinase 2 RNase 2 nucleotide-binding protein 2 Klotho 2 C11 2 ICS 2 EGFR 2 vascular endothelial growth factor receptor 2 NHERF2 2 CDK2 2 hepatocyte growth factor 2 dynorphin 2 RNO 2 constitutive nitric oxide synthase 2 CK1 2 caveolin-2 2 PGI 2 P18 2 rhodopsin kinase 2 acid phosphatase 2 CAT 2 AGE 2 IKK 2 P-glycoprotein 2 more...

Disease NAME 100 hypertension 79 cancer 77 ischemia 63 heart failure 63 tumor 60 PDE 45 depression 44 diabetes 37 malaria 33 atherosclerosis 31 pertussis 27 erectile dysfunction 25 Alzheimer's disease 24 pulmonary hypertension 24 obesity 22 stroke 21 SDS 20 neuroblastoma 16 colon cancer 16 sepsis 15 sepsis 15 gastric cancer 15 myocardial infarction 15 myocardial ischemia 13 vascular disease 13 type 2 diabetes 12 breast cancer 12 hyperglycemia 12 asthma 11 glioma 10 congestive heart failure 10 heart disease 9 MLC 9 colorectal cancer 9 GSH 8 ATM 8 uterus 8 cardiovascular disease 8 diabetic nephropathy 8 AGS 8 tumor growth 7 LTD 7 cold 7 cholera 7 tetanus 7 tumorigenesis 6 MCF 6 carcinoma 6 Parkinson's disease 6 anemia 6 tumor progression 6 memory impairment 5 carcinogenesis 5 mole 5 adenocarcinoma 5 HIV 5 pheochromocytoma 5 plaque 5 cerebral ischemia 5 metabolic syndrome 5 tularemia 5 Frey 5 melanoma 5 sickle cell disease 5 coccidiosis 5 thalassemia 5 mole 5 acute myocardial infarction 5 Blocking 5 FAS 5 lymphoma 4 AS1 4 SMC 4 amnesia 4 Wilson's disease 4 SEM 4 idiopathic thrombocytopenic purpura 4 infectious diseases 4 lung cancer 4 iron deficiency 4 immunodeficiency 4 leukemia 4 cystic fibrosis 4 coronary artery disease 4 chronic obstructive pulmonary disease 4 schizophrenia 4 coronary heart disease 4 Evans 3 Still 3 MBS 3 liver fibrosis 3 non-small cell lung cancer 3 hepatic encephalopathy 3 hepatocellular carcinoma 3 Adenovirus 3 lung carcinoma 3 ventricular hypertrophy 3 renal disease 3 CCD 3 polycystic kidney 3 sensorineural hearing loss 3 cardiomyopathy 3 diabetic retinopathy 3 Luminal 3 SCH 3 CCD 3 PDD 3 osteosarcoma 3 cognitive impairment 3 Infection 3 Endothelial dysfunction 3 chronic pain 3 Pulmonary arterial hypertension 3 infertility 3 worms 3 toxoplasmosis 3 RGS 3 Thoracic 3 ovarian cancer 3 Brown 3 mental retardation 3 amyotrophic lateral sclerosis 3 osteoporosis 3 Mycoplasma 3 mental retardation 3 osteoarthritis 3 ICD 2 suicide 2 obsessive-compulsive disorder 2 stomatitis 2 arthritis 2 psychological stress 2 multiple sclerosis 2 lung disease 2 subarachnoid hemorrhage 2 encephalomyelitis 2 paroxysmal nocturnal hemoglobinuria 2 Steroids 2 epididymis 2 retinoblastoma 2 achromatopsia 2 PAF 2 Melanoma 2 pulmonary edema 2 prediabetes 2 ICS 2 retinitis pigmentosa 2 peripheral neuropathy 2 PIN 2 glaucoma 2 metastases 2 chronic renal failure 2 alcohol abuse 2 renal insufficiency 2 Hodgkin's disease 2 APC 2 right heart failure 2 thrombocytopenia 2 myelodysplastic syndrome 2 addiction 2 urethra 2 LIN 2 prostate cancer 2 intermittent claudication 2 myocarditis 2 Huntington's disease 2 essential hypertension 2 CHH 2 Giant 2 B-cell lymphoma 2 rheumatoid arthritis 2 familial adenomatous polyposis 2 arteriosclerosis 2 brain edema 2 cornea 2 abdominal aortic aneurysm 2 SAR 2 renal ischemia 2 macular degeneration 2 PIN 2 AAA 2 hereditary spherocytosis 2 Adhesion 2 dehydration 2 glioblastoma 2 portal hypertension 2 renal failure 2 Bardet-Biedl syndrome 2 chronic myeloid leukemia 2 MRS 2 Hypertrophic 2 intraocular pressure 2 cirrhosis 2 mitral regurgitation 1 uterine leiomyosarcoma 1 CNC2 1 coronary occlusion 1 cocaine addiction 1 volvulus 1 GCE 1 HRS 1 warts 1 Bladder 1 ketosis 1 proteinuria 1 bone cancer 1 Chronic kidney disease (CKD) 1 blindness 1 cytomegalovirus 1 posttraumatic stress disorder 1 Multiple carboxylase deficiency 1 hyperlipidemia 1 gastritis 1 rhabdomyosarcoma 1 multiple myeloma 1 CLN3 1 cognitive deficit 1 pituitary adenoma 1 glucose intolerance 1 encephalitis 1 carcinoma of the esophagus 1 cholestasis 1 muscular atrophy 1 small cell lung cancer 1 NOD 1 migraine 1 glomerulosclerosis 1 Chagas 1 FHM2 1 muscular dystrophy 1 postmenopausal bone loss 1 Mycobacterium 1 EPI 1 Wuchereria 1 esophageal cancer 1 ischemic cardiomyopathy 1 aortic stenosis 1 impotence 1 disinhibition 1 Vidal 1 tuberculosis 1 hearing disorder 1 SCD 1 myeloproliferative disorders 1 thyroid cancer 1 TAM 1 Hepatotoxicity 1 Diaz 1 hemoglobinopathies 1 developmental delay 1 hemolytic uremic syndrome 1 Epstein 1 HCI 1 adenocarcinoma of the colon 1 Bladder 1 unstable angina 1 type 1 diabetes 1 STS 1 fibrosarcoma 1 hypertensive cardiomyopathy 1 learning disorder 1 LAD 1 alcoholism 1 Renal interstitial fibrosis 1 hyperinsulinemia 1 brain tumor 1 ADHD 1 hemiplegic migraine 1 squamous cell carcinoma 1 physical dependence 1 idiopathic dilated cardiomyopathy 1 ischemic ulcer 1 primary pulmonary hypertension 1 eosinophilia 1 schistosomiasis 1 HSP 1 chronic liver disease 1 antidiuresis 1 medulloblastoma 1 diabetic cardiomyopathy 1 male infertility 1 dilated cardiomyopathy 1 giant cell arteritis 1 colitis 1 parkinsonism 1 PAPA 1 CDS 1 lipoma 1 anxiety state 1 anal fissure 1 teratoma 1 autism 1 EIA 1 Krabbe disease 1 Renal fibrosis 1 disseminated intravascular coagulation 1 liver cancer 1 skin disease 1 SCID 1 chondrosarcoma 1 hyperphosphatemia 1 rare disease 1 COPD 1 choriocarcinoma 1 acute monocytic leukemia 1 Leukemia 1 confusion 1 Mitchell 1 PCA 1 nerve lesion 1 LCD 1 sexual dysfunction 1 chronic disease 1 respiratory disease 1 cerebral vasospasm 1 Spring viremia of carp 1 ICC 1 opisthorchiasis 1 Tag 1 lung metastases 1 esophageal cancer 1 insulinoma 1 paracoccidioidomycosis 1 bronchospasm 1 Pineal 1 Waterhouse-Friderichsen syndrome 1 ash 1 aggressiveness 1 sleep apnea 1 hepatoblastoma 1 memory disorder 1 optic atrophy 1 membranous nephropathy 1 sleep disturbances 1 alcoholic fatty liver 1 drug abuse 1 DM1 1 mimicry 1 cleft palate 1 retinopathy of prematurity 1 Foot-and-mouth disease 1 varices 1 Bladder 1 pemphigoid 1 G6PD deficiency 1 IVF 1 liver disease 1 PSS 1 Duchenne muscular dystrophy 1 vasculitis 1 eye disease 1 Schistosoma mansoni 1 cardiovascular risk factor 1 meningococcal infection 1 West 1 TMJ 1 inflammatory bowel disease 1 coagulopathy 1 EBV infection 1 intracranial aneurysm 1 ventricular dilatation 1 platelet disorder 1 hypoglycemia 1 irritable bowel syndrome 1 drug addiction 1 hypertensive heart disease 1 wasting 1 coma 1 AD8 1 Dissociation 1 IVA 1 dyslipidemia 1 HCG 1 Vascular lesions 1 Harada 1 metabolic disorder 1 CSE 1 dyskinesia 1 glioblastoma multiforme 1 hypercholesterolemia 1 tumor angiogenesis 1 preeclampsia 1 gout 1 nystagmus 1 PDB 1 dyspepsia 1 metastatic breast cancer 1 CAM 1 MLS 1 delayed speech 1 liver cancer 1 glomerulonephritis 1 nephritis 1 ICC 1 papillary thyroid cancer 1 cervical cancer 1 Barrett's esophagus 1 viremia 1 HGF 1 mental illness 1 seminoma 1 virus infection 1 SM1 1 PTP 1 Diabetes and Pregnancy 1

Symptom pain 40 diarrhea 8 collapse 6 angina 6 functional recovery 3 acute pain 3 seizures 2 hypercapnia 2 spasm 2 anesthesia 2 dystonia 2 overweight 1 bradykinesia 1 cerebellar ataxia 1 analgesia 1 hypotonia 1 nausea and vomiting 1 Lower urinary tract symptoms 1 orofacial pain 1 hepatomegaly 1 clumsiness 1 anorexia 1 Anoxia 1 Noise-induced hearing loss 1 splenomegaly 1 rundown 1 arthralgia 1 cough 1 cachexia 1 starvation 1 fatigue 1 constipation 1 respiratory distress 1 vomiting 1 memory loss 1 myoclonus 1 hemiplegia 1

Drug Cardiovasc 25 Nitric Oxide 19 nitroglycerin 18 caffeine 17 Forskolin 16 ROS 15 Sodium nitroprusside 15 lysine 11 Angiotensin II 11 MAP 9 Monit 8 GEO 4 CIA 4 Asn 4 Viagra 4 IFN-gamma 4 Vardenafil 4 NADH 4 Heme 4 Nephron 4 Viagra 4 Methylene blue 4 CaCl2 3 Rolipram 3 Levitra 3 Leaf 3 Indomethacin 3 Levitra 3 ascorbate 3 CaCl2 3 CaCl2 3 Ouabain 3 Iloprost 2 Alliance 2 ICI 2 IL-2 2 Glucagon 2 EE2 2 Alarin 2 Cilostazol 2 Carperitide 2 Ethanol 2 K-252a 2 Darifenacin 1 Glycyrrhiza 1 Histamine 1 Primacor 1 Dial 1 Atropine 1 Vitamin K 1 Phosphatidylserine 1 Theophylline 1 Silica 1 CSF 1 BoNT/A 1 Honey 1 TTC 1 Cicletanine 1 Indolidan 1 Estrogens 1 BOTOX 1 FeCl3 1 Gel 1 TAC 1 Glycerol 1 Photofrin 1 Glutathione 1 Bosentan 1 Dermatol 1 Etoposide 1 Donepezil 1 EPI 1 IL-1ra 1 Bosentan 1 -deoxyadenosine 1 Captopril 1 Diphenhydramine 1 Adenosine triphosphate 1 ABC 1 L-tyrosine 1 Vinpocetine 1 TAK 1 Primacor 1 Trental 1 Nephron 1 Rhubarb 1 APD 1 Alanine 1 CAM 1 Papaverine 1 Glybenclamide 1 Arsenic trioxide 1 Liraglutide 1 TiO2 1 TAT 1 CTX 1

Enzyme PKG 2515 protein kinase 2085 guanylate cyclase 453 AMPK 319 protein kinase C 310 phosphodiesterase 231 mitogen-activated protein kinase 181 NO synthase 143 NOS 77 ATPase 65 ERK 60 calcineurin 59 PDE 58 CaMKII 39 myosin light chain kinase 36 phospholipase C 35 thrombin 34 protein phosphatase 2A 34 MEK 32 adenylate cyclase 30 CPT 27 CPT 26 CPT 26 focal adhesion kinase 26 AMP-activated protein kinase 24 phosphatidylinositol 3-kinase 24 superoxide dismutase 22 caspase-3 21 luciferase 19 AMPK 17 cGMP phosphodiesterase 17 trypsin 16 catalase 15 alkaline phosphatase 14 NADPH oxidase 14 proteasome 13 GSK 12 NADPH oxidase 12 peroxidase 11 heme oxygenase 10 renin 10 PDK1 9 glutathione S-transferase 8 cdc2 8 glucose-6-phosphate dehydrogenase 7 phosphorylase kinase 7 PARP 7 ACS 6 hormone-sensitive lipase 6 MAP 6 MPP 6 RNA polymerase 5 5'-nucleotidase 5 tyrosine hydroxylase 5 phosphoglycerate kinase 5 arginase 5 lactate dehydrogenase 5 tyrosinase 5 aldehyde dehydrogenase 5 NADPH-diaphorase 4 complex I 4 phosphoinositide 3-kinase 4 succinate dehydrogenase 4 phospholipase D 4 aldehyde dehydrogenase 4 aldehyde dehydrogenase 4 aldehyde dehydrogenase 4 ACE 4 aldehyde dehydrogenase 4 GRK5 4 PI-PLC 3 apyrase 3 caspase-8 3 caspase-9 3 lysozyme 3 chloramphenicol acetyltransferase 3 phosphoribulokinase 3 APC 3 furin 3 xanthine oxidase 3 collagenase 3 CD10 3 creatine kinase 3 alanine aminotransferase 3 GRK2 3 ADP-ribosyltransferase 3 acetyl-CoA carboxylase 3 ADP-ribosyltransferase 3 transcriptase 3 reverse transcriptase 3 MEKK1 2 mu-calpain 2 m-calpain 2 aequorin 2 RNase 2 pyruvate kinase 2 AMP-activated kinase 2 ADPase 2 STR 2 P-glycoprotein 2 aspartate aminotransferase 2 TSP-1 2 acid phosphatase 2 choline acetyltransferase 2 sucrase 2 IKK 2 AGT 2 glucose-6-phosphatase 2 thioredoxin reductase 2 matrix metalloproteinase 2 2 phospholipase A2 2 ornithine decarboxylase 2 lipase 2 matrix metalloproteinase 9 2 rhodopsin kinase 2 glyceraldehyde-3-phosphate dehydrogenase 2 hexokinase 2 C3 convertase 2 RNase 2 polo-like kinase 1 2 sucrase-isomaltase 2 chymotrypsin 2 phosphoglucomutase 2 PTPase 2 ascorbate peroxidase 1 TMT 1 PRE 1 caspase-6 1 prolidase 1 tryptase 1 dihydrofolate reductase 1 caspase-6 1 GCA 1 sphingomyelin synthase 1 type 1 protein phosphatase 1 gamma-glutamylcysteine synthetase 1 alpha-glucosidase 1 3-mercaptopyruvate sulfurtransferase 1 12-lipoxygenase 1 phenylalanine hydroxylase 1 pyruvate dehydrogenase 1 DNase 1 invertase 1 plasmin 1 neuraminidase 1 pyruvate dehydrogenase 1 1-hydroxylase 1 proteinase K 1 pepsin 1 sphingosine kinase 1 prolyl hydroxylase 1 peroxiredoxin 1 ornithine aminotransferase 1 CPR 1 urokinase-type plasminogen activator 1 3-hydroxy-3-methylglutaryl-CoA reductase 1 TOR 1 myosin ATPase 1 adenosine kinase 1 factor C 1 diaphorase 1 malate dehydrogenase 1 calcium pump 1 endonuclease 1 MDR 1 hexosaminidase 1 isocitrate dehydrogenase 1 glutathione reductase 1 elastase 1 neutral sphingomyelinase 1 gamma-glutamyl transpeptidase 1 thymidine kinase 1 PAH 1 MMP 1 TSA 1 thermolysin 1 lipoprotein lipase 1 dimethylarginine dimethylaminohydrolase 1 phosphorylase 1 CNPase 1 sulfiredoxin 1 propionyl-CoA carboxylase 1 TAT 1 cytochrome oxidase 1 NAD glycohydrolase 1 pyruvate dehydrogenase 1 DCF 1 adenosine deaminase 1 aromatic L-amino acid decarboxylase 1 phosphofructokinase 1 propionyl-CoA carboxylase 1 CAD 1 glucose oxidase 1 prostacyclin synthase 1 purine nucleoside phosphorylase 1 acetylcholinesterase 1 SNO 1 PRPP synthetase 1 guanase 1 botulinum neurotoxin 1 TACE 1 RNase P 1 adenosine deaminase 1 CAD 1 6-phosphofructo-2-kinase 1 guanylate kinase 1 CAD 1 AMP deaminase 1 PHT 1 cathepsin B 1 deaminase 1 alpha-amylase 1 GAS 1 lysyl oxidase 1 CDH 1 N-acetylglucosaminyltransferase 1 CPL 1 hypoxanthine-guanine phosphoribosyltransferase 1 monoamine oxidase 1

Compound cGMP 1590 nitric oxide 715 cAMP 502 calcium 454 sodium 242 Dec 189 GMP 181 ATP 173 arginine 167 8-Br-cGMP 158 serine 127 threonine 103 oxygen 94 phosphate 77 potassium 75 DNA 71 AMP 64 glucose 57 alanine 54 tyrosine 54 glutamate 51 water 47 Clin 44 Cardiol 43 bromide 39 ADP 36 ADP 36 ADP 36 hydrogen 35 cysteine 35 Sildenafil 35 salt 34 lysine 28 acetate 28 NMDA 27 nitrate 26 CPT 26 CPT 26 DEA 25 DEA 25 DEA 25 CO2 25 GTP 23 PEG 21 ACh 21 leucine 20 Phe 20 SDS 20 TNF 19 noradrenaline 19 MEK 19 GABA 19 Ile 18 GABA 18 DETA 17 sulfate 17 COS 17 caffeine 17 methionine 17 Off 17 PMA 16 prostacyclin 16 5-HT 16 Ang II 16 Mg2+ 16 Forskolin 16 ethanol 16 AMPA 15 Asp 15 BNP 15 His 14 PMA 14 Angiotensin II 14 manganese 13 Estrogen 12 proline 12 pyridine 12 Estrogen 12 H2S 12 DEAE 12 glycerol 12 NH2 11 isoquinoline 11 Isoproterenol 10 Triton X-100 10 PGE 10 adenylate 10 phosphoserine 10 DT3 10 Neuronal 10 4-chlorophenyl 9 Insulin 9 urea 9 H2O2 9 Gly 9 nitrogen 9 Nitroglycerin 9 4-chlorophenyl 9 2-methylpiperazine 9 GSH 8 superoxide radical 8 NADPH 8 N-acetylcysteine 8 Glutamate 8 prostaglandin E1 8 NADPH 8 GSH 8 nicotinamide 8 cobalt 7 Serine 7 iodine 7 zinc 7 diacetate 7 LTD 7 GDP 7 dUTP 7 iron 7 MPP 6 TEA 6 4-AP 6 Carbachol 6 ornithine 6 ornithine 6 ACS 6 H2S 6 PGE2 6 nickel 6 isoleucine 6 TEA 6 MPP 6 MAP 6 ornithine 6 nonyl 6 ACS 6 tryptophan 6 ornithine 6 aldosterone 6 GF 109203X 6 isoleucine 6 galactose 6 ornithine 6 Dopamine 6 ADP-ribose 5 Casein 5 NAD 5 NAD 5 silver 5 HCl 5 1-methylpiperidine 5 Methylene blue 5 pyrimidine 5 MTT 5 Cyclic ADP-ribose 5 pyrimidine 5 UTP 5 glutamic acid 5 aspartic acid 5 acetic acid 5 2,3-diphosphoglycerate 4 Estradiol 4 aspartic acid 4 CIT 4 Glibenclamide 4 Phosphatidylinositol 4 Cereb 4 MDA 4 tryptophan 4 Sulindac 4 Progesterone 4 Luminal 4 tryptophan 4 copper 4 COX 4 barium 4 MPTP 4 aspartic acid 4 ammonia 4 Adenosine 4 NADH 4 aspartic acid 4 Wortmannin 4 Nitrate 4 Heme 4 tryptophan 4 Genistein 4 APAP 4 Tempol 3 Glu-Glu 3 Salt 3 Panam 3 Bisphenol A 3 HCO 3 APV 3 Morphine 3 Nitrite 3 Norepinephrine 3 glutamine 3 TOF 3 pentose 3 pentose 3 Naringenin 3 Tris 3 Naringenin 3 Indomethacin 3 pentose 3 Verapamil 3 Bisphenol A 3 cyclohexane 3 DAD 3 Thrombin 3 Diabetol 3 benzoic acid 3 pentose 3 Cytochalasin D 3 EDTA 3 Verapamil 3 aldehyde 3 BRL 3 Collagen 3 CaCl2 3 PNP 3 Guo 3 NO3 3 PPI 3 SCN 3 40S 3 cyanide 3 Phorbol 3 Guo 3 EDTA 3 Ouabain 3 SPM 2 QNB 2 creatinine 2 DDVP 2 propionic acid 2 Inositol 2 Dipyridamole 2 Tamoxifen 2 Thromboxane 2 Protoporphyrin IX 2 TPA 2 Vimentin 2 PDB 2 Hemin 2 STZ 2 Calcitonin 2 2-hydroxyethyl 2 Hemin 2 ASA 2 Nitrite 2 Glucagon 2 Nifedipine 2 CPP 2 tin 2 titanium 2 Cysteine 2 AGE 2 cadmium 2 THP 2 2-hydroxyethyl 2 aminomethyl 2 DHA 2 phosphoric acid 2 Melatonin 2 CAT 2 Tamoxifen 2 NADP 2 Phenylephrine 2 Dipyridamole 2 PIN 2 DDP 2 HEPES 2 ammonium 2 Resveratrol 2 ICI 2 Naringin 2 2-hydroxyethyl 2 Biotin 2 2-hydroxyethyl 2 valine 2 NPR 2 Hearts 2 2-hydroxyethyl 2 UDP 2 2-hydroxyethyl 2 Dipyridamole 2 APT 2 AAA 2 DAMP 2 Hemin 2 Rapamycin 2 Pac 2 MPT 2 kaempferol 2 Okadaic acid 2 CAT 2 Dipyridamole 2 6-aminonicotinamide 2 formaldehyde 2 CAT 2 DAMP 2 CAM 2 acetaldehyde 2 gamma-aminobutyric acid 2 Tyrosine 2 Milrinone 2 2-hydroxyethyl 2 1-chloro-2,4-dinitrobenzene 2 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine 2 Hemin 2 THP 2 propionic acid 2 2-hydroxyethyl 2 Methacholine 2 FK506 2 TPA 2 LIN 2 Hemin 2 Retinal 2 DAG 2 alloxan 2 Genipin 2 Diltiazem 2 Hearts 2 Diltiazem 2 BSO 2 CPP 2 chlorine 1 dichloroacetonitrile 1 CBS 1 benzene 1 Arsenite 1 DOC 1 oxalic acid 1 Trypsin 1 Baicalin 1 morpholine 1 Diabetol 1 AAB 1 Naringin 1 2-naphthol 1 ETH 1 Pinacidil 1 Osthole 1 Curcumin 1 1,3-benzodioxole 1 Ferulic acid 1 oxalic acid 1 MgCl2 1 Hydroxyurea 1 DBD 1 HVA 1 Barbiturate 1 oxalic acid 1 isopropanol 1 Histone 1 Nitro-L-arginine 1 UGA 1 acetone 1 oxalic acid 1 Allergan 1 oxalic acid 1 2-naphthol 1 AEA 1 guanidine 1 oxalic acid 1 Bilirubin 1 Fostriecin 1 oxalic acid 1 quinuclidine 1 AAB 1 Ruthenium red 1 1-methyl-1,2,3,6-tetrahydropyridine 1 Dexmedetomidine 1 cyclopentyl 1 Oil Red O 1 ATF 1 L-carnitine 1 2,2,6,6-tetramethylpiperidine 1 CTX 1 Substance P 1 2-imidazolidinone 1 PHT 1 perchloric acid 1 aldehyde 1 DAPT 1 IPA 1 palmitic acid 1 PD 123319 1 tetraphosphate 1 hydroxylamine 1 piperidine 1 2-nonenal 1 octyl 1 IAA-94 1 Amide 1 TEM 1 IPA 1 CPA 1 Rhodamine B 1 TBP 1 Vasopressin 1 oxalic acid 1 Adrenal 1 Histamine 1 palmitic acid 1 Atropine 1 Alanine 1 phthalaldehyde 1 Malvidin 1 2-naphthol 1 CAP 1 PLA 1 MDR 1 retinoic acid 1 D-600 1 protocatechuate 1 Paraquat 1 Oxytocin 1 p-Synephrine 1 EPC 1 CDH 1 1H-imidazole 1 N-acetylaspartate 1 mercury 1 NPPB 1 DBP 1 INa 1 oxalic acid 1 L-DOPA 1 hydroxide 1 Elastin 1 Ascorbic acid 1 8-Bromoinosine 1 GAP 1 myristic acid 1 pentaerythritol 1 Stimul 1 Hemoglobin 1 Pioglitazone 1 rubidium 1 Ginsenoside Re 1 silicon 1 naphthalene 1 G11 1 EPSP 1 ethanesulfonic acid 1 strontium 1 Losartan 1 Nystatin 1 Paraquat 1 Chelerythrine 1 Androgen 1 Phenylalanine 1 hydroxylamine 1 1H-indazole 1 Salix 1 Ferulic acid 1 Minocycline 1 Carrageenan 1 CCC 1 TXA2 1 GC-1 1 bis(2-chloroethyl) 1 CdCl2 1 Phytic acid 1 dipropyl 1 12-hydroperoxyeicosatetraenoic acid 1 ETH 1 Isoform 1 oxalic acid 1 benzophenone 1 20-HETE 1 Quercetin 1 CIT 1 Menadione 1 CPA 1 Neu5Ac 1 GPT 1 ANA 1 DRB 1 Capsaicin 1 Theophylline 1 N2O 1 IPA 1 IPC 1 IMP 1 Sialic acid 1 CPA 1 Sodium 1 piperidine 1 Yellow 1 IPA 1 Nystatin 1 BBM 1 CoA 1 SO2 1 HCI 1 oxalic acid 1 pyrrolidine 1 FAP 1 ITG 1 4-methoxybenzyl 1 Papaverine 1 PAS 1 hexadecyl 1 Bradykinin 1 Isoliquiritigenin 1 chalcone 1 Nicorandil 1 Austin 1 Relaxant 1 Arachidonic acid 1 PCI 1 Tunicamycin 1 Oil Red O 1 BOP 1 Synephrine 1 DIDS 1 BayK8644 1 DPI 1 Xamoterol 1 Uridine 1 DCL 1 FAP 1 Pirenzepine 1 PCM 1 Leucine 1 DTT 1 piperazine 1 D-Serine 1 D-NONOate 1 TMB 1 1H-pyrazole 1 ADR 1 TTC 1 Triton 1 AET 1 quinuclidine 1 PEG 1 DPP 1 ethyl acetate 1 Isopropylamine 1 oxalic acid 1 isoxazole 1 Ubiquitin 1 chlorobenzene 1 Sarcosine 1 Pluronic 1 1H-imidazole 1 octyl 1 SO3 1 PAG 1 oxalic acid 1 phenol 1 myricetin 1 Pro-Gly 1 Thapsigargin 1 Fluo-3 1 Hematoxylin 1 4-methoxybenzenesulfonamide 1 Cinnamyl alcohol 1 Magnolol 1 DTT 1 Phosphoserine 1 Halothane 1 Cinnamaldehyde 1 C6H12O5 1 IPC 1 MK801 1 Suramin 1 2,4-dichlorophenyl 1 pyrrolidine 1 Cortisol 1 TFE 1 Cyanidin 1 VP-16 1 oxalic acid 1 LY 294002 1 RELA 1 myristic acid 1 Staurosporine 1 octyl 1 oxalic acid 1 TBP 1 DCM 1 Diphenhydramine 1 oxalic acid 1 hydrazine 1 Repaglinide 1 ALP 1 SPD 1 Tris 1 oxalic acid 1 2,4-dichlorophenyl 1 Phosphatidylserine 1 ANA 1 CaO 1 Nobiletin 1 SITS 1 TACE 1 glucose-6-phosphate 1 Cinnamic acid 1 PAH 1 Chelerythrine 1 ethanimidamide 1 AEA 1 Ins(1,4,5)P3 1 BaCl2 1 Optimal 1 Carvacrol 1 Staurosporine 1 malonyl-CoA 1 Azathioprine 1 CPA 1 1H-pyrazole 1 Plasmin 1 ethanesulfonic acid 1 Adriamycin 1 DBP 1 BUdR 1 Tirofiban 1 CCC 1 vitamin D 1

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