Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:2.7.11.12 (
PKG
)
2,515
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
.
Concepts found in the documents ranked by [
Frequency
|
Pointwise Mutual Information
|
Symmetric Conditional Probability
] .
Human Gene/Protein
PKG
2515
cAMP-dependent protein kinase
302
PKA
298
guanylate cyclase
289
phosphodiesterase
231
nitric oxide synthase
221
Mol
215
Sep
179
ATP
173
soluble guanylyl cyclase
171
guanylyl cyclase
164
PKC
161
calmodulin
110
vasodilator-stimulated phosphoprotein
89
atrial natriuretic peptide
80
MAPK
78
threonine
72
phosphatase
70
ATPase
65
natriuretic peptide
63
AMP
62
eNOS
57
PDE5
56
neuronal nitric oxide synthase
54
C-type natriuretic peptide
53
ERK1
53
insulin
48
ERK
48
p38
46
RhoA
45
PDE
45
inducible nitric oxide synthase
43
angiotensin II
38
myosin light chain
37
collagen
37
ADP
36
protein kinase inhibitor
36
Rho
36
PI3K
36
tyrosine kinase
36
more...
Disease
NAME
100
hypertension
79
cancer
77
heart failure
63
ischemia
63
tumor
60
PDE
45
depression
44
diabetes
37
malaria
33
atherosclerosis
31
pertussis
27
erectile dysfunction
25
Alzheimer's disease
24
pulmonary hypertension
24
obesity
22
stroke
21
SDS
20
colon cancer
16
neuroblastoma
16
gastric cancer
15
sepsis
15
sepsis
15
myocardial infarction
15
myocardial ischemia
13
vascular disease
13
type 2 diabetes
12
hyperglycemia
12
breast cancer
12
asthma
11
congestive heart failure
10
glioma
10
heart disease
9
MLC
9
colorectal cancer
9
GSH
8
cardiovascular disease
8
AGS
8
ATM
8
uterus
8
more...
Symptom
pain
40
diarrhea
8
collapse
6
angina
6
functional recovery
3
acute pain
3
seizures
2
hypercapnia
2
spasm
2
anesthesia
2
dystonia
2
overweight
1
bradykinesia
1
cerebellar ataxia
1
analgesia
1
hypotonia
1
nausea and vomiting
1
Lower urinary tract symptoms
1
orofacial pain
1
hepatomegaly
1
clumsiness
1
anorexia
1
Anoxia
1
Noise-induced hearing loss
1
splenomegaly
1
rundown
1
arthralgia
1
cough
1
cachexia
1
starvation
1
fatigue
1
constipation
1
respiratory distress
1
vomiting
1
memory loss
1
myoclonus
1
hemiplegia
1
Drug
Cardiovasc
25
Nitric Oxide
19
nitroglycerin
18
caffeine
17
Forskolin
16
ROS
15
Sodium nitroprusside
15
Angiotensin II
11
lysine
11
MAP
9
Monit
8
Viagra
4
Vardenafil
4
NADH
4
GEO
4
Heme
4
IFN-gamma
4
Nephron
4
CIA
4
Asn
4
Viagra
4
Methylene blue
4
Levitra
3
CaCl2
3
Levitra
3
Ouabain
3
ascorbate
3
Leaf
3
CaCl2
3
Indomethacin
3
Rolipram
3
CaCl2
3
EE2
2
IL-2
2
Iloprost
2
Glucagon
2
Cilostazol
2
ICI
2
Alarin
2
Alliance
2
more...
Enzyme
PKG
2515
protein kinase
2085
guanylate cyclase
453
AMPK
319
protein kinase C
310
phosphodiesterase
231
mitogen-activated protein kinase
181
NO synthase
143
NOS
77
ATPase
65
ERK
60
calcineurin
59
PDE
58
CaMKII
39
myosin light chain kinase
36
phospholipase C
35
protein phosphatase 2A
34
thrombin
34
MEK
32
adenylate cyclase
30
CPT
27
CPT
26
CPT
26
focal adhesion kinase
26
phosphatidylinositol 3-kinase
24
AMP-activated protein kinase
24
superoxide dismutase
22
caspase-3
21
luciferase
19
cGMP phosphodiesterase
17
AMPK
17
trypsin
16
catalase
15
NADPH oxidase
14
alkaline phosphatase
14
proteasome
13
NADPH oxidase
12
GSK
12
peroxidase
11
heme oxygenase
10
more...
Compound
cGMP
1590
nitric oxide
715
cAMP
502
calcium
454
sodium
242
Dec
189
GMP
181
ATP
173
arginine
167
8-Br-cGMP
158
serine
127
threonine
103
oxygen
94
phosphate
77
potassium
75
DNA
71
AMP
64
glucose
57
alanine
54
tyrosine
54
glutamate
51
water
47
Clin
44
Cardiol
43
bromide
39
ADP
36
ADP
36
ADP
36
cysteine
35
Sildenafil
35
hydrogen
35
salt
34
acetate
28
lysine
28
NMDA
27
nitrate
26
CPT
26
CPT
26
CO2
25
DEA
25
more...