Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:2.7.11.12 (PKG)
2,515 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
PKG 2515
cAMP-dependent protein kinase 302
PKA 298
guanylate cyclase 289
phosphodiesterase 231
nitric oxide synthase 221
Mol 215
Sep 179
ATP 173
soluble guanylyl cyclase 171
guanylyl cyclase 164
PKC 161
calmodulin 110
vasodilator-stimulated phosphoprotein 89
atrial natriuretic peptide 80
MAPK 78
threonine 72
phosphatase 70
ATPase 65
natriuretic peptide 63
AMP 62
eNOS 57
PDE5 56
neuronal nitric oxide synthase 54
C-type natriuretic peptide 53
ERK1 53
insulin 48
ERK 48
p38 46
RhoA 45
PDE 45
inducible nitric oxide synthase 43
angiotensin II 38
myosin light chain 37
collagen 37
ADP 36
protein kinase inhibitor 36
Rho 36
PI3K 36
tyrosine kinase 36
more...
Disease
NAME 100
hypertension 79
cancer 77
heart failure 63
ischemia 63
tumor 60
PDE 45
depression 44
diabetes 37
malaria 33
atherosclerosis 31
pertussis 27
erectile dysfunction 25
Alzheimer's disease 24
pulmonary hypertension 24
obesity 22
stroke 21
SDS 20
colon cancer 16
neuroblastoma 16
gastric cancer 15
sepsis 15
sepsis 15
myocardial infarction 15
myocardial ischemia 13
vascular disease 13
type 2 diabetes 12
hyperglycemia 12
breast cancer 12
asthma 11
congestive heart failure 10
glioma 10
heart disease 9
MLC 9
colorectal cancer 9
GSH 8
cardiovascular disease 8
AGS 8
ATM 8
uterus 8
more...
Symptom
pain 40
diarrhea 8
collapse 6
angina 6
functional recovery 3
acute pain 3
seizures 2
hypercapnia 2
spasm 2
anesthesia 2
dystonia 2
overweight 1
bradykinesia 1
cerebellar ataxia 1
analgesia 1
hypotonia 1
nausea and vomiting 1
Lower urinary tract symptoms 1
orofacial pain 1
hepatomegaly 1
clumsiness 1
anorexia 1
Anoxia 1
Noise-induced hearing loss 1
splenomegaly 1
rundown 1
arthralgia 1
cough 1
cachexia 1
starvation 1
fatigue 1
constipation 1
respiratory distress 1
vomiting 1
memory loss 1
myoclonus 1
hemiplegia 1
Drug
Cardiovasc 25
Nitric Oxide 19
nitroglycerin 18
caffeine 17
Forskolin 16
ROS 15
Sodium nitroprusside 15
Angiotensin II 11
lysine 11
MAP 9
Monit 8
Viagra 4
Vardenafil 4
NADH 4
GEO 4
Heme 4
IFN-gamma 4
Nephron 4
CIA 4
Asn 4
Viagra 4
Methylene blue 4
Levitra 3
CaCl2 3
Levitra 3
Ouabain 3
ascorbate 3
Leaf 3
CaCl2 3
Indomethacin 3
Rolipram 3
CaCl2 3
EE2 2
IL-2 2
Iloprost 2
Glucagon 2
Cilostazol 2
ICI 2
Alarin 2
Alliance 2
more...
Enzyme
PKG 2515
protein kinase 2085
guanylate cyclase 453
AMPK 319
protein kinase C 310
phosphodiesterase 231
mitogen-activated protein kinase 181
NO synthase 143
NOS 77
ATPase 65
ERK 60
calcineurin 59
PDE 58
CaMKII 39
myosin light chain kinase 36
phospholipase C 35
protein phosphatase 2A 34
thrombin 34
MEK 32
adenylate cyclase 30
CPT 27
CPT 26
CPT 26
focal adhesion kinase 26
phosphatidylinositol 3-kinase 24
AMP-activated protein kinase 24
superoxide dismutase 22
caspase-3 21
luciferase 19
cGMP phosphodiesterase 17
AMPK 17
trypsin 16
catalase 15
NADPH oxidase 14
alkaline phosphatase 14
proteasome 13
NADPH oxidase 12
GSK 12
peroxidase 11
heme oxygenase 10
more...
Compound
cGMP 1590
nitric oxide 715
cAMP 502
calcium 454
sodium 242
Dec 189
GMP 181
ATP 173
arginine 167
8-Br-cGMP 158
serine 127
threonine 103
oxygen 94
phosphate 77
potassium 75
DNA 71
AMP 64
glucose 57
alanine 54
tyrosine 54
glutamate 51
water 47
Clin 44
Cardiol 43
bromide 39
ADP 36
ADP 36
ADP 36
cysteine 35
Sildenafil 35
hydrogen 35
salt 34
acetate 28
lysine 28
NMDA 27
nitrate 26
CPT 26
CPT 26
CO2 25
DEA 25
more...