Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:2.7.11.12 (PKG)
 2,515 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
PKG 2515
cAMP-dependent protein kinase 302
PKA 298
guanylate cyclase 289
phosphodiesterase 231
nitric oxide synthase 221
Mol 215
Sep 179
ATP 173
soluble guanylyl cyclase 171
guanylyl cyclase 164
PKC 161
calmodulin 110
vasodilator-stimulated phosphoprotein 89
atrial natriuretic peptide 80
MAPK 78
threonine 72
phosphatase 70
ATPase 65
natriuretic peptide 63
AMP 62
eNOS 57
PDE5 56
neuronal nitric oxide synthase 54
C-type natriuretic peptide 53
ERK1 53
ERK 48
insulin 48
p38 46
PDE 45
RhoA 45
inducible nitric oxide synthase 43
angiotensin II 38
collagen 37
myosin light chain 37
ADP 36
Rho 36
protein kinase inhibitor 36
tyrosine kinase 36
PI3K 36
thrombin 35
atrial natriuretic factor 33
myosin 33
VASP 32
phosphoprotein 31
adenylyl cyclase 30
protein phosphatase 30
CREB 29
SNAP 29
endothelial nitric oxide synthase 29
dimeric 29
endoplasmic reticulum 28
membrane-bound 27
adenylate cyclase 27
phospholamban 27
myosin light chain kinase 27
CPT 26
polypeptide 26
leucine zipper 26
endothelin-1 25
ANP 25
Bcl-2 25
phosphorylating 24
Rho kinase 24
cGMP phosphodiesterase 24
Ang II 24
phosphatidylinositol 3-kinase 24
caspase-3 24
CA1 24
MEK 23
olfactory 22
NPR-A 21
Phosphodiesterase 21
GTP 21
SIN 21
cytokine 21
histone 20
SDS 20
MYPT1 20
PKI 20
calcineurin 20
TNF 19
superoxide dismutase 19
extracellular signal-regulated kinase 19
GTPase 19
lipopolysaccharide 18
tumor necrosis factor 18
PLC 18
AKT 18
collecting duct 17
hemoglobin 17
PDE2 17
NMDA receptor 17
CaMKII 17
AMPK 17
ryanodine receptor 17
PKG1 17
GMP 17
NPR-B 17
cGKI 17
bradykinin 16
Mem 16
thioredoxin 16
heme oxygenase-1 16
axonal 15
GABA 15
epidermal growth factor receptor 15
ROS 15
LPS 15
TNF-alpha 15
HEK 15
BK channel 15
BNP 14
catalase 14
mitogen-activated protein 14
brain-derived neurotrophic factor 14
alkaline phosphatase 14
epidermal growth factor 14
mTOR 14
DAF 13
Gen 13
platelet-derived growth factor 13
cyclic nucleotide phosphodiesterase 13
catenin 13
proteasome 13
JNK 13
cyclooxygenase 13
PKB 13
casein kinase 12
cardiac muscle 12
ionotropic 12
cGKII 12
calpain 12
PRKG1 12
L-type calcium channel 12
IL-6 12
TGF-beta 11
p44 11
c-fos 11
cystic fibrosis transmembrane conductance regulator 11
proximal tubule 11
ERK2 11
Protein kinase 11
GSK 11
p21 11
NMR 11
CNP 11
EGF 11
ANG 11
5-hydroxytryptamine 11
G-substrate 11
AP-1 11
MAP kinase 11
spermatozoa 10
NOS1 10
p53 10
casein 10
albumin 10
c-Jun 10
titin 10
more...
Disease
NAME 100
hypertension 79
cancer 77
heart failure 63
ischemia 63
tumor 60
PDE 45
depression 44
diabetes 37
malaria 33
atherosclerosis 31
pertussis 27
erectile dysfunction 25
Alzheimer's disease 24
pulmonary hypertension 24
obesity 22
stroke 21
SDS 20
colon cancer 16
neuroblastoma 16
sepsis 15
gastric cancer 15
sepsis 15
myocardial infarction 15
vascular disease 13
myocardial ischemia 13
type 2 diabetes 12
breast cancer 12
hyperglycemia 12
asthma 11
congestive heart failure 10
glioma 10
colorectal cancer 9
heart disease 9
MLC 9
diabetic nephropathy 8
AGS 8
cardiovascular disease 8
ATM 8
GSH 8
uterus 8
cold 7
tetanus 7
tumor growth 7
cholera 7
LTD 7
tumor progression 6
anemia 6
carcinoma 6
Parkinson's disease 6
MCF 6
tumorigenesis 6
memory impairment 5
Frey 5
plaque 5
mole 5
acute myocardial infarction 5
mole 5
metabolic syndrome 5
HIV 5
Blocking 5
sickle cell disease 5
thalassemia 5
carcinogenesis 5
adenocarcinoma 5
melanoma 5
tularemia 5
coccidiosis 5
pheochromocytoma 5
cerebral ischemia 5
FAS 5
immunodeficiency 4
chronic obstructive pulmonary disease 4
SEM 4
AS1 4
lung cancer 4
SMC 4
idiopathic thrombocytopenic purpura 4
schizophrenia 4
amnesia 4
infectious diseases 4
leukemia 4
iron deficiency 4
lymphoma 4
cystic fibrosis 4
Wilson's disease 4
coronary artery disease 4
coronary heart disease 4
SCH 3
ventricular hypertrophy 3
Still 3
Mycoplasma 3
cognitive impairment 3
ovarian cancer 3
worms 3
diabetic retinopathy 3
cardiomyopathy 3
osteoporosis 3
sensorineural hearing loss 3
osteosarcoma 3
Luminal 3
MBS 3
Endothelial dysfunction 3
polycystic kidney 3
lung carcinoma 3
renal disease 3
RGS 3
CCD 3
amyotrophic lateral sclerosis 3
Brown 3
liver fibrosis 3
mental retardation 3
toxoplasmosis 3
Thoracic 3
infertility 3
Pulmonary arterial hypertension 3
Adenovirus 3
chronic pain 3
CCD 3
Infection 3
Evans 3
PDD 3
mental retardation 3
hepatocellular carcinoma 3
hepatic encephalopathy 3
non-small cell lung cancer 3
osteoarthritis 3
Melanoma 2
ICD 2
suicide 2
Steroids 2
obsessive-compulsive disorder 2
encephalomyelitis 2
LIN 2
myelodysplastic syndrome 2
subarachnoid hemorrhage 2
PIN 2
retinitis pigmentosa 2
lung disease 2
multiple sclerosis 2
psychological stress 2
dehydration 2
paroxysmal nocturnal hemoglobinuria 2
chronic renal failure 2
addiction 2
retinoblastoma 2
urethra 2
prostate cancer 2
Huntington's disease 2
stomatitis 2
APC 2
right heart failure 2
hereditary spherocytosis 2
AAA 2
peripheral neuropathy 2
pulmonary edema 2
epididymis 2
PIN 2
Hodgkin's disease 2
alcohol abuse 2
more...
Symptom
pain 40
diarrhea 8
collapse 6
angina 6
functional recovery 3
acute pain 3
seizures 2
hypercapnia 2
spasm 2
anesthesia 2
dystonia 2
overweight 1
bradykinesia 1
cerebellar ataxia 1
analgesia 1
hypotonia 1
nausea and vomiting 1
Lower urinary tract symptoms 1
orofacial pain 1
hepatomegaly 1
clumsiness 1
anorexia 1
Anoxia 1
Noise-induced hearing loss 1
splenomegaly 1
rundown 1
arthralgia 1
cough 1
cachexia 1
starvation 1
fatigue 1
constipation 1
respiratory distress 1
vomiting 1
memory loss 1
myoclonus 1
hemiplegia 1
Drug
Cardiovasc 25
Nitric Oxide 19
nitroglycerin 18
caffeine 17
Forskolin 16
ROS 15
Sodium nitroprusside 15
lysine 11
Angiotensin II 11
MAP 9
Monit 8
GEO 4
CIA 4
Asn 4
Viagra 4
IFN-gamma 4
Vardenafil 4
NADH 4
Heme 4
Nephron 4
Viagra 4
Methylene blue 4
CaCl2 3
Rolipram 3
Levitra 3
Leaf 3
Indomethacin 3
Levitra 3
ascorbate 3
CaCl2 3
CaCl2 3
Ouabain 3
Iloprost 2
Alliance 2
ICI 2
IL-2 2
Glucagon 2
EE2 2
Alarin 2
Cilostazol 2
Carperitide 2
Ethanol 2
K-252a 2
Darifenacin 1
Glycyrrhiza 1
Histamine 1
Primacor 1
Dial 1
Atropine 1
Vitamin K 1
Phosphatidylserine 1
Theophylline 1
Silica 1
CSF 1
BoNT/A 1
Honey 1
TTC 1
Cicletanine 1
Indolidan 1
Estrogens 1
BOTOX 1
FeCl3 1
Gel 1
TAC 1
Glycerol 1
Photofrin 1
Glutathione 1
Bosentan 1
Dermatol 1
Etoposide 1
Donepezil 1
EPI 1
IL-1ra 1
Bosentan 1
-deoxyadenosine 1
Captopril 1
Diphenhydramine 1
Adenosine triphosphate 1
ABC 1
L-tyrosine 1
Vinpocetine 1
TAK 1
Primacor 1
Trental 1
Nephron 1
Rhubarb 1
APD 1
Alanine 1
CAM 1
Papaverine 1
Glybenclamide 1
Arsenic trioxide 1
Liraglutide 1
TiO2 1
TAT 1
CTX 1
Enzyme
PKG 2515
protein kinase 2085
guanylate cyclase 453
AMPK 319
protein kinase C 310
phosphodiesterase 231
mitogen-activated protein kinase 181
NO synthase 143
NOS 77
ATPase 65
ERK 60
calcineurin 59
PDE 58
CaMKII 39
myosin light chain kinase 36
phospholipase C 35
protein phosphatase 2A 34
thrombin 34
MEK 32
adenylate cyclase 30
CPT 27
CPT 26
focal adhesion kinase 26
CPT 26
AMP-activated protein kinase 24
phosphatidylinositol 3-kinase 24
superoxide dismutase 22
caspase-3 21
luciferase 19
cGMP phosphodiesterase 17
AMPK 17
trypsin 16
catalase 15
NADPH oxidase 14
alkaline phosphatase 14
proteasome 13
GSK 12
NADPH oxidase 12
peroxidase 11
heme oxygenase 10
renin 10
PDK1 9
glutathione S-transferase 8
cdc2 8
phosphorylase kinase 7
glucose-6-phosphate dehydrogenase 7
PARP 7
ACS 6
MAP 6
hormone-sensitive lipase 6
MPP 6
RNA polymerase 5
5'-nucleotidase 5
arginase 5
tyrosine hydroxylase 5
lactate dehydrogenase 5
aldehyde dehydrogenase 5
phosphoglycerate kinase 5
tyrosinase 5
aldehyde dehydrogenase 4
phosphoinositide 3-kinase 4
succinate dehydrogenase 4
phospholipase D 4
aldehyde dehydrogenase 4
GRK5 4
NADPH-diaphorase 4
ACE 4
aldehyde dehydrogenase 4
aldehyde dehydrogenase 4
complex I 4
apyrase 3
caspase-8 3
caspase-9 3
lysozyme 3
chloramphenicol acetyltransferase 3
phosphoribulokinase 3
APC 3
furin 3
creatine kinase 3
PI-PLC 3
collagenase 3
acetyl-CoA carboxylase 3
GRK2 3
xanthine oxidase 3
CD10 3
alanine aminotransferase 3
ADP-ribosyltransferase 3
ADP-ribosyltransferase 3
transcriptase 3
reverse transcriptase 3
MEKK1 2
mu-calpain 2
m-calpain 2
aequorin 2
RNase 2
pyruvate kinase 2
AMP-activated kinase 2
ADPase 2
STR 2
P-glycoprotein 2
TSP-1 2
glucose-6-phosphatase 2
acid phosphatase 2
IKK 2
glyceraldehyde-3-phosphate dehydrogenase 2
phospholipase A2 2
matrix metalloproteinase 9 2
rhodopsin kinase 2
matrix metalloproteinase 2 2
thioredoxin reductase 2
hexokinase 2
lipase 2
ornithine decarboxylase 2
AGT 2
C3 convertase 2
sucrase 2
RNase 2
polo-like kinase 1 2
sucrase-isomaltase 2
aspartate aminotransferase 2
choline acetyltransferase 2
chymotrypsin 2
phosphoglucomutase 2
PTPase 2
ascorbate peroxidase 1
TMT 1
PRE 1
caspase-6 1
prolidase 1
tryptase 1
dihydrofolate reductase 1
caspase-6 1
GCA 1
sphingomyelin synthase 1
type 1 protein phosphatase 1
gamma-glutamylcysteine synthetase 1
alpha-glucosidase 1
3-mercaptopyruvate sulfurtransferase 1
12-lipoxygenase 1
phenylalanine hydroxylase 1
pyruvate dehydrogenase 1
DNase 1
invertase 1
plasmin 1
neuraminidase 1
pyruvate dehydrogenase 1
1-hydroxylase 1
proteinase K 1
CPR 1
peroxiredoxin 1
sphingosine kinase 1
prolyl hydroxylase 1
adenosine kinase 1
factor C 1
urokinase-type plasminogen activator 1
TSA 1
MDR 1
endonuclease 1
dimethylarginine dimethylaminohydrolase 1
thymidine kinase 1
more...
Compound
cGMP 1590
nitric oxide 715
cAMP 502
calcium 454
sodium 242
Dec 189
GMP 181
ATP 173
arginine 167
8-Br-cGMP 158
serine 127
threonine 103
oxygen 94
phosphate 77
potassium 75
DNA 71
AMP 64
glucose 57
tyrosine 54
alanine 54
glutamate 51
water 47
Clin 44
Cardiol 43
bromide 39
ADP 36
ADP 36
ADP 36
hydrogen 35
Sildenafil 35
cysteine 35
salt 34
acetate 28
lysine 28
NMDA 27
CPT 26
nitrate 26
CPT 26
DEA 25
DEA 25
CO2 25
DEA 25
GTP 23
ACh 21
PEG 21
Phe 20
leucine 20
SDS 20
noradrenaline 19
GABA 19
TNF 19
MEK 19
GABA 18
Ile 18
DETA 17
Off 17
methionine 17
COS 17
sulfate 17
caffeine 17
Forskolin 16
ethanol 16
prostacyclin 16
5-HT 16
Mg2+ 16
PMA 16
Ang II 16
BNP 15
Asp 15
AMPA 15
His 14
PMA 14
Angiotensin II 14
manganese 13
H2S 12
proline 12
glycerol 12
pyridine 12
Estrogen 12
DEAE 12
Estrogen 12
NH2 11
isoquinoline 11
Triton X-100 10
DT3 10
phosphoserine 10
PGE 10
Neuronal 10
adenylate 10
Isoproterenol 10
urea 9
Insulin 9
nitrogen 9
4-chlorophenyl 9
H2O2 9
4-chlorophenyl 9
Gly 9
2-methylpiperazine 9
Nitroglycerin 9
prostaglandin E1 8
nicotinamide 8
NADPH 8
superoxide radical 8
GSH 8
NADPH 8
Glutamate 8
GSH 8
N-acetylcysteine 8
Serine 7
iron 7
diacetate 7
GDP 7
LTD 7
iodine 7
zinc 7
dUTP 7
cobalt 7
Dopamine 6
ornithine 6
H2S 6
4-AP 6
PGE2 6
ornithine 6
ornithine 6
aldosterone 6
TEA 6
ACS 6
TEA 6
MAP 6
MPP 6
galactose 6
ornithine 6
GF 109203X 6
isoleucine 6
ornithine 6
MPP 6
ACS 6
isoleucine 6
tryptophan 6
nonyl 6
nickel 6
Carbachol 6
acetic acid 5
Cyclic ADP-ribose 5
pyrimidine 5
aspartic acid 5
MTT 5
Methylene blue 5
UTP 5
HCl 5
NAD 5
Casein 5
glutamic acid 5
1-methylpiperidine 5
ADP-ribose 5
pyrimidine 5
NAD 5
silver 5
aspartic acid 4
Wortmannin 4
more...