Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:2.7.11.12 (
PKG
)
2,515
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Regulation of cytoskeletal dynamics is required to coordinate cell adhesion, morphology change and cell motility. Vasodilator-stimulated phosphoprotein (VASP) is an actin-binding protein which is composed of EVH1, EVH2 domains and
PRR
. It has been implicated in actin-based processes such as axon guidance, T cell polarization and fibroblast migrations. The regulation of VASP phosphorylation, which is controlled by
PKG
(
cGMP-dependent protein kinase
) and PKA (cAMP-dependent protein kinase), could correspond to the "switch" process in its communication with cytoskeleton during modification of focal adhesion.
...
PMID:[Roles of vasodilator-stimulated phosphoprotein in the regulation of cytoskeleton]. 1668 41
