Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:2.7.11.11 (
AMPK
)
12,425
document(s) hit in 31,850,051 MEDLINE articles (0.01 seconds)
.
Concepts found in the documents ranked by [
Frequency
|
Pointwise Mutual Information
|
Symmetric Conditional Probability
] .
Human Gene/Protein
AMPK
6226
cAMP-dependent protein kinase
6110
ATP
1352
insulin
1284
mTOR
1266
Mol
1171
AMP
736
Sep
726
AMP-activated protein kinase
537
calmodulin
506
PI3K
413
adenylate cyclase
410
AKT
408
LKB1
387
PKA
374
phosphodiesterase
346
PGC
332
MAPK
327
PKG
319
phosphatase
316
adiponectin
312
LC3
298
SIRT1
291
threonine
273
p53
271
ROS
259
adenylyl cyclase
248
AICAR
237
TNF
237
ERK
232
p38
226
caspase-3
220
ACC
216
ULK1
206
ATPase
202
endoplasmic reticulum
199
p62
199
PKC
188
phosphoprotein
186
ERK1
180
JNK
178
protein phosphatase
177
glucagon
174
histone
171
protein kinase inhibitor
169
Bcl-2
167
leptin
166
GLUT4
165
IL-6
163
polypeptide
160
acetyl-CoA carboxylase
156
ADP
154
GTP
153
cytokine
153
Beclin-1
150
PKI
148
peroxisome proliferator-activated receptor
142
PPAR
135
Nrf2
135
SDS
130
CREB
129
phosphorylating
125
tyrosine kinase
116
IRS-1
111
phospholamban
108
casein
106
p21
106
tumor necrosis factor
104
lipopolysaccharide
103
CPT
103
ubiquitin
103
collagen
103
eNOS
101
calcineurin
100
Adiponectin
100
Dictyostelium
100
alkaline phosphatase
99
superoxide dismutase
96
FAS
95
phosphorylase kinase
95
more...
Disease
cancer
1250
tumor
787
obesity
659
diabetes
646
type 2 diabetes
387
fatty liver
206
breast cancer
202
hepatocellular carcinoma
184
tumor growth
178
hyperglycemia
176
ischemia
162
Alzheimer's disease
151
tumorigenesis
141
SDS
130
metabolic syndrome
123
atherosclerosis
116
hypertension
102
cholera
101
heart failure
100
depression
99
FAS
97
prostate cancer
91
lung cancer
90
cardiovascular disease
87
pertussis
84
tumor progression
81
colorectal cancer
79
carcinoma
77
hyperlipidemia
76
lymphoma
72
glucose intolerance
71
carcinogenesis
71
dyslipidemia
70
MCF
68
Parkinson's disease
68
stroke
68
leukemia
66
myocardial ischemia
65
GSH
64
myocardial infarction
63
adenocarcinoma
62
neuroblastoma
62
glioma
59
alcoholic fatty liver
59
melanoma
55
ATM
54
cold
54
colon cancer
49
pancreatic cancer
46
non-small cell lung cancer
44
glioblastoma
43
tuberous sclerosis
43
diabetic nephropathy
41
cerebral ischemia
40
liver disease
39
NAME
38
sepsis
38
sepsis
38
osteosarcoma
38
hypoglycemia
36
cystic fibrosis
36
liver cancer
36
ovarian cancer
35
gastric cancer
34
PDE
33
cognitive impairment
33
pheochromocytoma
32
cardiomyopathy
32
metabolic disorder
32
liver fibrosis
31
hyperinsulinemia
31
HIV
30
acute myeloid leukemia
30
squamous cell carcinoma
29
liver cancer
29
mole
28
mole
28
diabetic cardiomyopathy
28
Blocking
28
renal cell carcinoma
27
more...
Symptom
starvation
184
pain
47
fatigue
31
collapse
27
functional recovery
21
exhaustion
20
overweight
20
cachexia
14
diarrhea
13
seizures
13
weakness
11
anesthesia
10
hunger
10
memory loss
8
hypothermia
7
respiratory distress
6
thinning
5
ataxia
5
rundown
5
anorexia
5
hypercapnia
4
analgesia
4
hepatomegaly
4
stigma
4
hyperoxia
4
tremor
4
low back pain
3
bradykinesia
2
Anoxia
2
chills
2
angina
2
acute pain
2
Neuropathic pain
2
insomnia
2
cough
2
menopausal symptoms
2
back pain
2
pallor
2
Cushingoid
1
vomiting
1
syncope
1
stomach cramps
1
myalgia
1
Catch
1
muscle rigidity
1
twitching
1
spasticity
1
shoulder pain
1
bitter taste
1
nausea
1
constipation
1
ophthalmoplegia
1
acidity
1
HSA
1
cyanosis
1
hemoptysis
1
incoordination
1
dyspnea
1
POA
1
Cushingoid
1
Scratch
1
skin damage
1
headache
1
abdominal pain
1
neurological disability
1
Spots
1
Ill
1
Drug
ROS
259
Forskolin
114
lysine
78
Asn
42
NADH
38
MAP
37
Glucagon
35
caffeine
33
Parkin
29
Parkin
29
Gel
28
Cardiovasc
28
PTH
25
Ethanol
21
Monit
21
CaCl2
17
CaCl2
17
CaCl2
17
IL-2
16
Dermatol
13
Ginseng
13
RFP
13
Rolipram
12
DNase I
12
Retinoic acid
11
Liraglutide
11
K-252a
11
Fructose
11
Nephron
11
IFN-gamma
11
ascorbate
11
CSF
10
Rosiglitazone
10
Histamine
9
vitamin E
9
L-tyrosine
8
citric acid
8
Cilostazol
8
CAM
7
Sodium nitroprusside
7
Leaf
7
BH4
7
Itraconazole
7
EE2
7
ALA
7
Sorafenib
7
3-Methyladenine
7
G418
6
Arsenic trioxide
6
Angiotensin II
6
Iloprost
6
Emodin
5
Glycyrrhiza
5
Nitric Oxide
5
Emodin
5
Alanine
5
-deoxyadenosine
5
ICI
5
NH3
5
Trifluoperazine
5
TAK
5
Ara-A
5
EPA
5
Simvastatin
5
Adriamycin
4
Acadesine
4
Salicylate
4
Kenyan
4
GEO
4
Indomethacin
4
Adenosine Monophosphate
4
Glycerol
4
Methylene blue
4
Docetaxel
4
Taxol
4
Ezetimibe
4
Troglitazone
4
Portal
4
Orlistat
4
nitroglycerin
4
more...
Enzyme
AMPK
12425
protein kinase
6885
AMP-activated protein kinase
6254
AMPK
6226
protein kinase C
884
mitogen-activated protein kinase
817
adenylate cyclase
434
calcineurin
358
ERK
353
phosphodiesterase
348
PKG
319
CaMKII
244
ATPase
212
acetyl-CoA carboxylase
162
focal adhesion kinase
158
caspase-3
153
superoxide dismutase
152
CPT
135
phosphorylase
122
phosphorylase kinase
112
trypsin
111
CPT
103
CPT
103
MEK
101
alkaline phosphatase
99
phospholipase C
98
myosin light chain kinase
91
luciferase
89
proteasome
88
catalase
86
PARP
86
alanine aminotransferase
82
GSK
81
polo-like kinase 1
80
PDE
78
complex I
76
hormone-sensitive lipase
75
aspartate aminotransferase
74
tyrosine hydroxylase
74
phosphatidylinositol 3-kinase
71
phosphoenolpyruvate carboxykinase
69
lactate dehydrogenase
55
glutathione S-transferase
55
lipase
54
guanylate cyclase
52
NO synthase
49
citrate synthase
49
thrombin
49
protein phosphatase 2A
49
TOR
48
pyruvate kinase
48
PDK1
46
phosphofructokinase
43
phosphoenolpyruvate carboxykinase
38
phosphoenolpyruvate carboxykinase
38
NADPH oxidase
37
NADPH oxidase
37
AST
37
glutathione peroxidase
33
lipoprotein lipase
31
AMP-activated kinase
31
peroxidase
30
IKK
30
ATP synthase
30
chymotrypsin
29
creatine kinase
29
caspase-1
29
NOS
29
cdc2
26
6-phosphofructo-2-kinase
26
trehalase
25
glucose-6-phosphatase
25
NQO1
25
phosphoinositide 3-kinase
25
STK11
24
chloramphenicol acetyltransferase
24
urokinase-type plasminogen activator
23
pyruvate dehydrogenase
23
caspase-9
23
hexokinase
23
more...
Compound
cAMP
3049
glucose
1607
ATP
1352
calcium
1310
Dec
850
AMP
839
DNA
655
oxygen
654
phosphate
622
serine
593
threonine
518
sodium
428
cGMP
384
alanine
292
Metformin
284
Metformin
284
arginine
282
tyrosine
278
AICAR
252
AICAR
239
TNF
237
acetate
234
water
232
sulfate
206
Clin
200
adenylate
190
nitric oxide
177
DEAE
166
ADP
163
Insulin
157
leucine
155
GTP
155
ADP
154
ADP
154
lysine
151
SDS
141
Mg2+
138
hydrogen
127
glutamate
124
salt
116
Forskolin
114
Gly
110
ethanol
109
methionine
108
NAD
106
potassium
105
CPT
103
CPT
103
cysteine
96
glycerol
91
Phe
89
Asp
88
NH2
85
NAD
85
MDA
82
galactose
82
nitrogen
80
Cardiol
79
ACTH
79
MTT
77
Resveratrol
75
urea
71
palmitic acid
70
CoA
67
His
66
GSH
65
Ile
65
GSH
65
MEK
64
phosphoserine
63
bromide
59
glutamine
59
prostaglandin E1
55
manganese
53
proline
51
Isoproterenol
50
Triton X-100
50
palmitic acid
48
retinoic acid
42
N-acetylcysteine
42
more...