Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:2.7.11.11 (AMPK)
 12,425 document(s) hit in 31,850,051 MEDLINE articles (0.01 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
AMPK 6226
cAMP-dependent protein kinase 6110
ATP 1352
insulin 1284
mTOR 1266
Mol 1171
AMP 736
Sep 726
AMP-activated protein kinase 537
calmodulin 506
PI3K 413
adenylate cyclase 410
AKT 408
LKB1 387
PKA 374
phosphodiesterase 346
PGC 332
MAPK 327
PKG 319
phosphatase 316
adiponectin 312
LC3 298
SIRT1 291
threonine 273
p53 271
ROS 259
adenylyl cyclase 248
TNF 237
AICAR 237
ERK 232
p38 226
caspase-3 220
ACC 216
ULK1 206
ATPase 202
endoplasmic reticulum 199
p62 199
PKC 188
phosphoprotein 186
ERK1 180
JNK 178
protein phosphatase 177
glucagon 174
histone 171
protein kinase inhibitor 169
Bcl-2 167
leptin 166
GLUT4 165
IL-6 163
polypeptide 160
acetyl-CoA carboxylase 156
ADP 154
cytokine 153
GTP 153
Beclin-1 150
PKI 148
peroxisome proliferator-activated receptor 142
PPAR 135
Nrf2 135
SDS 130
CREB 129
phosphorylating 125
tyrosine kinase 116
IRS-1 111
phospholamban 108
p21 106
casein 106
tumor necrosis factor 104
collagen 103
lipopolysaccharide 103
CPT 103
ubiquitin 103
eNOS 101
Dictyostelium 100
Adiponectin 100
calcineurin 100
alkaline phosphatase 99
superoxide dismutase 96
phosphorylase kinase 95
FAS 95
S6K1 94
glycogen synthase 92
epididymal 89
ACTH 89
gut 88
STAT3 88
inducible nitric oxide synthase 87
proteasome 86
NAD 85
fatty acid synthase 85
LPS 81
protein kinase B 79
LC3B 79
GSK 79
tyrosine hydroxylase 78
CA1 77
CaMKII 77
TSC2 77
hormone-sensitive lipase 75
MEK 73
SOD 72
nitric oxide synthase 71
PDB 71
glucose transporter 71
myosin light chain kinase 71
phosphatidylinositol 3-kinase 71
PARP 70
adipokine 70
myosin 70
p65 69
serine/threonine kinase 69
SREBP-1 69
catalase 68
cardiac muscle 67
CD36 66
FRAP 65
SREBP-1c 65
GSH 64
insulin receptor 64
beta-endorphin 64
PTEN 64
HO-1 62
uncoupling protein 1 61
membrane protein 60
membrane-bound 60
GTPase 60
sirtuin 1 59
VEGF 59
MAP kinase 58
PKB 58
microsomal 57
peroxisome proliferator-activated receptor gamma 57
mitogen-activated protein 57
Gen 56
IGF-1 56
NLRP3 56
catenin 55
inhibitor 2 55
14-3-3 55
lactate dehydrogenase 53
epidermal growth factor 53
ATG5 53
angiotensin II 52
c-fos 52
A-kinase anchoring protein 52
NMDA receptor 51
extracellular signal-regulated kinase 51
GLUT1 51
casein kinase 51
cytochrome c 51
erythroid 50
spermatozoa 50
HEK 50
NMR 50
thrombin 50
ghrelin 49
ribosomal protein S6 49
TFAM 49
citrate synthase 49
TOR 48
more...
Disease
cancer 1250
tumor 787
obesity 659
diabetes 646
type 2 diabetes 387
fatty liver 206
breast cancer 202
hepatocellular carcinoma 184
tumor growth 178
hyperglycemia 176
ischemia 162
Alzheimer's disease 151
tumorigenesis 141
SDS 130
metabolic syndrome 123
atherosclerosis 116
hypertension 102
cholera 101
heart failure 100
depression 99
FAS 97
prostate cancer 91
lung cancer 90
cardiovascular disease 87
pertussis 84
tumor progression 81
colorectal cancer 79
carcinoma 77
hyperlipidemia 76
lymphoma 72
glucose intolerance 71
carcinogenesis 71
dyslipidemia 70
MCF 68
Parkinson's disease 68
stroke 68
leukemia 66
myocardial ischemia 65
GSH 64
myocardial infarction 63
adenocarcinoma 62
neuroblastoma 62
glioma 59
alcoholic fatty liver 59
melanoma 55
ATM 54
cold 54
colon cancer 49
pancreatic cancer 46
non-small cell lung cancer 44
tuberous sclerosis 43
glioblastoma 43
diabetic nephropathy 41
cerebral ischemia 40
liver disease 39
osteosarcoma 38
sepsis 38
sepsis 38
NAME 38
cystic fibrosis 36
hypoglycemia 36
liver cancer 36
ovarian cancer 35
gastric cancer 34
PDE 33
cognitive impairment 33
pheochromocytoma 32
metabolic disorder 32
cardiomyopathy 32
liver fibrosis 31
hyperinsulinemia 31
HIV 30
acute myeloid leukemia 30
squamous cell carcinoma 29
liver cancer 29
mole 28
mole 28
diabetic cardiomyopathy 28
Blocking 28
osteoporosis 27
renal cell carcinoma 27
dementia 26
colitis 26
Nonalcoholic fatty liver 26
metastases 25
Peutz-Jeghers syndrome 25
Huntington's disease 25
plaque 25
muscular atrophy 25
sickle cell disease 24
renal disease 24
heart disease 23
asthma 23
acute promyelocytic leukemia 21
osteoarthritis 21
worms 21
Brown 20
cervical cancer 20
tuberculosis 20
SCD 20
lung carcinoma 20
rheumatoid arthritis 20
polycystic ovary syndrome 20
malnutrition 20
chronic myeloid leukemia 19
Rous sarcoma 18
Hepatocellular carcinoma 18
INS 17
acute lymphoblastic leukemia 17
coronary artery disease 17
sarcoma 16
brain tumor 16
epilepsy 16
SCH 16
bladder cancer 16
endometrial cancer 15
TEM 15
insulinoma 15
type 1 diabetes 15
glioblastoma multiforme 15
uterus 15
SEM 15
Mycobacterium 15
Dissociation 15
polycystic kidney 15
TEM 15
hypercholesterolemia 14
hypertrophic cardiomyopathy 14
chronic disease 14
infectious diseases 14
chronic obstructive pulmonary disease 14
immunodeficiency 14
myopathy 14
EMT 14
cirrhosis 14
mammary tumor 13
arthritis 13
aggressiveness 13
virus infection 13
B-cell lymphoma 13
systemic lupus erythematosus 12
amyotrophic lateral sclerosis 12
chronic renal failure 12
malaria 12
MLC 11
tumor angiogenesis 11
hyperphagia 11
NOD 11
diabetic retinopathy 11
Glioblastoma 11
proteinuria 11
OPA1 11
influenza 11
multiple myeloma 11
Pineal 11
acute myocardial infarction 11
macular degeneration 11
Infection 11
gestational diabetes mellitus 11
lipid disorder 11
more...
Symptom
starvation 184
pain 47
fatigue 31
collapse 27
functional recovery 21
exhaustion 20
overweight 20
cachexia 14
diarrhea 13
seizures 13
weakness 11
anesthesia 10
hunger 10
memory loss 8
hypothermia 7
respiratory distress 6
thinning 5
ataxia 5
rundown 5
anorexia 5
hypercapnia 4
analgesia 4
hepatomegaly 4
stigma 4
hyperoxia 4
tremor 4
low back pain 3
bradykinesia 2
Anoxia 2
chills 2
angina 2
acute pain 2
Neuropathic pain 2
insomnia 2
cough 2
menopausal symptoms 2
back pain 2
pallor 2
Cushingoid 1
vomiting 1
syncope 1
stomach cramps 1
myalgia 1
Catch 1
muscle rigidity 1
twitching 1
spasticity 1
shoulder pain 1
bitter taste 1
nausea 1
constipation 1
ophthalmoplegia 1
acidity 1
HSA 1
cyanosis 1
hemoptysis 1
incoordination 1
dyspnea 1
POA 1
Cushingoid 1
Scratch 1
skin damage 1
headache 1
abdominal pain 1
neurological disability 1
Spots 1
Ill 1
Drug
ROS 259
Forskolin 114
lysine 78
Asn 42
NADH 38
MAP 37
Glucagon 35
caffeine 33
Parkin 29
Parkin 29
Gel 28
Cardiovasc 28
PTH 25
Monit 21
Ethanol 21
CaCl2 17
CaCl2 17
CaCl2 17
IL-2 16
RFP 13
Ginseng 13
Dermatol 13
Rolipram 12
DNase I 12
Fructose 11
K-252a 11
ascorbate 11
Nephron 11
Retinoic acid 11
Liraglutide 11
IFN-gamma 11
Rosiglitazone 10
CSF 10
vitamin E 9
Histamine 9
L-tyrosine 8
citric acid 8
Cilostazol 8
BH4 7
3-Methyladenine 7
CAM 7
ALA 7
Leaf 7
Sodium nitroprusside 7
Sorafenib 7
EE2 7
Itraconazole 7
Arsenic trioxide 6
G418 6
Angiotensin II 6
Iloprost 6
ICI 5
Alanine 5
Nitric Oxide 5
EPA 5
TAK 5
Emodin 5
Emodin 5
Glycyrrhiza 5
Ara-A 5
-deoxyadenosine 5
NH3 5
Trifluoperazine 5
Simvastatin 5
Methylene blue 4
Adriamycin 4
Indomethacin 4
Kenyan 4
Ezetimibe 4
Adenosine Monophosphate 4
Docetaxel 4
Acadesine 4
Troglitazone 4
Portal 4
Salicylate 4
GEO 4
nitroglycerin 4
Taxol 4
Orlistat 4
Glycerol 4
Bifidobacterium 4
ADM 3
TAC 3
Growth hormone 3
Balanol 3
MDS 3
CIA 3
Growth hormone 3
niacin 3
p75 3
PTC 3
Secretin 3
Vitamin K2 3
Exenatide 3
Heme 3
Pronase 3
Ouabain 3
DM1 3
ETA 3
Dasatinib 3
Luteinizing 3
Artesunate 3
balanced salt solution 3
Atropine 3
Fraction 3
ROC 3
CTX 3
Imatinib 3
ABC 3
TAT 2
CoCl2 2
GRF 2
CoCl2 2
Ginger 2
Penfluridol 2
Glutathione 2
DHT 2
Vitamin A 2
ETS 2
Theophylline 2
CTX 2
Gefitinib 2
1-Deoxynojirimycin 2
PFT 2
CTX 2
ATV 2
Fragment 2
Amiloride 2
R1881 2
FAD 2
Valsartan 2
NBT 2
Photofrin 2
Amiloride 2
Clopidogrel 2
Lovastatin 2
Donepezil 2
DMAP 2
uPA 2
Biopolymers 2
DHT 2
Fidarestat 2
Pramlintide 2
metformin hydrochloride 2
Triclosan 2
Elcatonin 2
Fidarestat 2
Sesamol 2
Salbutamol 2
Bupivacaine 2
CCL 2
MRC 2
Mutagen 2
PCB 2
ENT 2
FLP 2
TTC 2
DEX 2
Phosphatidylserine 2
Norplant 1
more...
Enzyme
AMPK 12425
protein kinase 6885
AMP-activated protein kinase 6254
AMPK 6226
protein kinase C 884
mitogen-activated protein kinase 817
adenylate cyclase 434
calcineurin 358
ERK 353
phosphodiesterase 348
PKG 319
CaMKII 244
ATPase 212
acetyl-CoA carboxylase 162
focal adhesion kinase 158
caspase-3 153
superoxide dismutase 152
CPT 135
phosphorylase 122
phosphorylase kinase 112
trypsin 111
CPT 103
CPT 103
MEK 101
alkaline phosphatase 99
phospholipase C 98
myosin light chain kinase 91
luciferase 89
proteasome 88
catalase 86
PARP 86
alanine aminotransferase 82
GSK 81
polo-like kinase 1 80
PDE 78
complex I 76
hormone-sensitive lipase 75
tyrosine hydroxylase 74
aspartate aminotransferase 74
phosphatidylinositol 3-kinase 71
phosphoenolpyruvate carboxykinase 69
lactate dehydrogenase 55
glutathione S-transferase 55
lipase 54
guanylate cyclase 52
NO synthase 49
citrate synthase 49
thrombin 49
protein phosphatase 2A 49
pyruvate kinase 48
TOR 48
PDK1 46
phosphofructokinase 43
phosphoenolpyruvate carboxykinase 38
phosphoenolpyruvate carboxykinase 38
AST 37
NADPH oxidase 37
NADPH oxidase 37
glutathione peroxidase 33
AMP-activated kinase 31
lipoprotein lipase 31
ATP synthase 30
peroxidase 30
IKK 30
creatine kinase 29
NOS 29
chymotrypsin 29
caspase-1 29
cdc2 26
6-phosphofructo-2-kinase 26
trehalase 25
phosphoinositide 3-kinase 25
glucose-6-phosphatase 25
NQO1 25
STK11 24
chloramphenicol acetyltransferase 24
hexokinase 23
renin 23
urokinase-type plasminogen activator 23
pyruvate dehydrogenase 23
caspase-9 23
collagenase 22
glyceraldehyde-3-phosphate dehydrogenase 22
ACE 21
ornithine decarboxylase 21
MAP 21
glucokinase 19
phospholipase A2 19
GRK2 18
pyruvate dehydrogenase 18
adenosine deaminase 18
pyruvate dehydrogenase 18
heme oxygenase 18
adenosine deaminase 18
calcium pump 18
RNA polymerase 17
glucose-6-phosphate dehydrogenase 17
eEF2 kinase 17
phenylalanine hydroxylase 16
P-glycoprotein 16
HK2 16
cholesterol esterase 16
succinate dehydrogenase 16
RNase 16
RNase 16
fructose-2,6-bisphosphatase 16
acetylcholinesterase 15
glyceraldehyde-3-phosphate dehydrogenase 15
APC 15
fructose 1,6-bisphosphatase 14
aldehyde dehydrogenase 14
ACS 14
beta-galactosidase 13
cytochrome oxidase 13
glyceraldehyde-3-phosphate dehydrogenase 13
glyceraldehyde-3-phosphate dehydrogenase 13
glyceraldehyde-3-phosphate dehydrogenase 13
aldehyde dehydrogenase 12
aldehyde dehydrogenase 12
aldehyde dehydrogenase 12
aldehyde dehydrogenase 12
caspase-8 11
reverse transcriptase 11
cathepsin D 10
alcohol dehydrogenase 10
acid phosphatase 10
MEKK1 10
cGMP phosphodiesterase 9
glutamate dehydrogenase 9
glutamate dehydrogenase 9
subtilisin 9
glutamate dehydrogenase 9
LPL 9
MPP 9
GRK5 8
cathepsin B 8
3-hydroxy-3-methylglutaryl coenzyme A reductase 8
21-hydroxylase 8
adenylate kinase 8
rhodopsin kinase 8
adenosine kinase 8
5'-nucleotidase 8
malate dehydrogenase 8
type 1 protein phosphatase 8
phospholipase D 7
acyl-CoA oxidase 7
PDH 7
CD10 7
tissue plasminogen activator 7
arginase 7
thymidine kinase 7
MMP 7
thermolysin 7
acyl-CoA dehydrogenase 7
O-GlcNAc transferase 7
enolase 7
tryptophan hydroxylase 6
demethylase 6
Mg2+-ATPase 6
topoisomerase 6
more...
Compound
cAMP 3049
glucose 1607
ATP 1352
calcium 1310
Dec 850
AMP 839
DNA 655
oxygen 654
phosphate 622
serine 593
threonine 518
sodium 428
cGMP 384
alanine 292
Metformin 284
Metformin 284
arginine 282
tyrosine 278
AICAR 252
AICAR 239
TNF 237
acetate 234
water 232
sulfate 206
Clin 200
adenylate 190
nitric oxide 177
DEAE 166
ADP 163
Insulin 157
leucine 155
GTP 155
ADP 154
ADP 154
lysine 151
SDS 141
Mg2+ 138
hydrogen 127
glutamate 124
salt 116
Forskolin 114
Gly 110
ethanol 109
methionine 108
NAD 106
potassium 105
CPT 103
CPT 103
cysteine 96
glycerol 91
Phe 89
Asp 88
NAD 85
NH2 85
MDA 82
galactose 82
nitrogen 80
ACTH 79
Cardiol 79
MTT 77
Resveratrol 75
urea 71
palmitic acid 70
CoA 67
His 66
Ile 65
GSH 65
GSH 65
MEK 64
phosphoserine 63
bromide 59
glutamine 59
prostaglandin E1 55
manganese 53
proline 51
Triton X-100 50
Isoproterenol 50
palmitic acid 48
PMA 42
retinoic acid 42
N-acetylcysteine 42
GABA 41
Rapamycin 40
GABA 39
prostacyclin 39
STZ 39
NADH 38
iron 38
THP 38
Guo 38
THP 38
H2O2 38
nicotinamide 38
NMDA 37
zinc 37
tryptophan 36
PGE2 36
ammonium 35
Glucagon 35
isoquinoline 34
Berberine 33
aspartic acid 33
Adenosine 33
caffeine 33
PMA 33
GDP 32
AMPA 32
PGE 32
Oil Red O 31
COS 31
Oil Red O 31
PEG 31
tryptophan 29
tryptophan 29
pentose 29
pentose 29
pentose 29
pentose 29
NADPH 29
NADPH 29
tryptophan 29
noradrenaline 28
aspartic acid 28
aspartic acid 28
aspartic acid 28
creatinine 27
glutamic acid 27
acetyl-CoA 27
pyrimidine 26
Adrenal 26
pyrimidine 26
TCA 25
Curcumin 25
TSC 25
8-Br-cGMP 25
Serine 25
Neuronal 25
Dopamine 25
PEG 24
cadmium 24
5-HT 24
GMP 23
MAP 22
CAT 21
CAT 21
CAT 21
TSH 21
Melatonin 21
malonyl-CoA 21
aldosterone 21
Glycogen synthase 21
Ang II 21
Casein 21
H2S 21
iodine 21
2-methylpiperazine 20
vitamin D 20
ACh 20
ammonia 20
Sucrose 19
more...