Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts: Gene/Protein Disease Symptom Drug Enzyme Compound   Target Concepts: Gene/Protein Disease Symptom Drug Enzyme Compound

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Query: EC:2.7.11.10 (IKK)
4,900 document(s) hit in 31,850,051 MEDLINE articles (0.01 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .

Human Gene/Protein IKK 2478 IkappaB kinase 1468 TBK1 766 p65 755 Mol 564 cytokine 554 TNF 506 IkappaBalpha 499 tumor necrosis factor 473 interferon 422 lipopolysaccharide 348 IL-6 339 IFN 334 p38 330 Sep 321 IRF3 318 TANK-binding kinase 1 314 JNK 289 NEMO 269 ubiquitin 267 LPS 257 MAPK 225 TLR4 217 inducible nitric oxide synthase 210 TNF-alpha 198 RIG-I 179 STING 179 IL-8 177 p50 174 ERK 173 proteasome 172 TAK1 152 TRAF6 151 insulin 148 IKK2 147 MyD88 146 AP-1 145 type I interferon 144 interferon regulatory factor 3 141 IL-1 136 tumor necrosis factor alpha 136 PI3K 132 cyclooxygenase-2 130 c-Jun 113 AKT 112 COX-2 112 caspase-3 110 TRAF2 109 ERK1 106 p53 105 IKBKB 104 Bcl-2 104 IKK1 96 interleukin-6 95 TANK 95 chemokine 95 MAVS 95 mitogen-activated protein 89 NIK 86 TNF receptor 84 TLR3 83 Ubiquitin 82 adaptor protein 82 MEK 81 TRIF 81 extracellular signal-regulated kinase 77 TRAF3 75 mTOR 75 nitric oxide synthase 73 AMP 71 IL-10 66 ICAM-1 65 IRF7 64 IFN-beta 62 p52 62 phosphatidylinositol 3-kinase 62 E3 ubiquitin ligase 61 endoplasmic reticulum 61 A20 61 cyclin D1 59 more...

Disease cancer 726 tumor 433 virus infection 215 tumorigenesis 152 breast cancer 120 leukemia 100 obesity 96 rheumatoid arthritis 85 carcinogenesis 78 diabetes 78 hepatocellular carcinoma 69 amyotrophic lateral sclerosis 67 tumor progression 64 tumor growth 57 lymphoma 55 ischemia 53 arthritis 53 prostate cancer 53 sepsis 52 type 2 diabetes 51 atherosclerosis 51 immunodeficiency 50 melanoma 49 sepsis 49 carcinoma 48 influenza 46 lung cancer 43 herpes simplex 42 infectious diseases 41 colitis 39 asthma 39 HIV 38 multiple myeloma 38 B-cell lymphoma 37 dementia 37 MCF 36 hepatitis C 33 adenocarcinoma 33 Alzheimer's disease 33 stomatitis 32 GSH 31 bacterial infection 31 Parkinson's disease 30 Mycobacterium 29 pancreatic cancer 29 CYLD 29 osteoarthritis 29 inflammatory bowel disease 28 Blocking 28 Hodgkin's disease 25 colon cancer 25 Epstein 25 hyperglycemia 24 squamous cell carcinoma 23 ovarian cancer 23 colorectal cancer 23 dermatitis 23 chronic obstructive pulmonary disease 22 systemic lupus erythematosus 22 autoimmune disease 22 tuberculosis 22 ATM 21 Infection 21 hepatitis B 21 glioma 21 NOD 21 cytomegalovirus 20 stroke 19 cardiovascular disease 19 acute myeloid leukemia 19 hepatitis 19 Kaposi's sarcoma 19 VISA 19 glaucoma 18 incontinentia pigmenti 18 osteoporosis 17 adult T-cell leukemia/lymphoma 17 metastases 17 cerebral ischemia 17 heart failure 16 more...

Symptom pain 20 starvation 15 diarrhea 15 cachexia 6 hypothermia 6 fatigue 4 collapse 3 erythema 3 vomiting 3 ataxia 3 weakness 2 splenomegaly 2 overweight 2 acute stress 2 analgesia 2 nausea 2 insomnia 2 memory loss 2 functional recovery 2 hyperoxia 2 exhaustion 2 anesthesia 1 cough 1 dysuria 1 Neuropathic pain 1 productive cough 1 angina 1 paresis 1 apathy 1 hypotonia 1 paresthesia 1 anorexia 1 cerebellar ataxia 1 Scratch 1 polyuria 1 dizziness 1 hepatomegaly 1 bone pain 1 swollen joints 1 impaired motor coordination 1 hypercapnia 1 seizures 1 Decreased activity 1 cancer pain 1 menopausal symptoms 1 bradypnea 1 arthralgia 1

Drug lysine 68 IFN-beta 52 ROS 49 IL-2 42 MAP 28 IFN-gamma 28 CSF 16 TAK 13 Dermatol 13 Parkin 9 Amlexanox 9 Retinoic acid 9 Parkin 9 p75 7 Gel 6 Bortezomib 6 Taxol 6 uPA 6 Auranofin 5 Arsenic trioxide 5 CCL 5 Asthma 5 ascorbate 5 Glycyrrhiza 4 Heme 4 vitamin E 4 Imatinib 4 IL-11 3 TAT 3 Angiotensin II 3 Salicylate 3 Glutathione 3 Ginger 3 Dasatinib 3 RAL 3 Alanine 3 Asn 3 Monit 3 Simvastatin 3 Cardiovasc 3 Ginseng 2 ETS 2 Rosiglitazone 2 Herceptin 2 CIA 2 MRC 2 Fluorescein 2 Docetaxel 2 ALA 2 Indomethacin 2 Fructose 2 Gelatin 2 G-CSF 2 Artesunate 2 Gefitinib 2 Rebamipide 1 APD 1 Kainic acid 1 Fulvestrant 1 EPA 1 CTA 1 GHRP 1 NADH 1 ID2 1 ABC 1 Vinpocetine 1 pyridoxal phosphate 1 Alliance 1 CTC 1 Moxifloxacin 1 Bevacizumab 1 Compound 16 1 Budesonide 1 balanced salt solution 1 K-252a 1 TEL 1 DEX 1 Propofol 1 ROC 1 CTX 1 more...

Enzyme IKK 4900 mitogen-activated protein kinase 725 protein kinase 269 ERK 245 proteasome 175 luciferase 157 MEK 149 protein kinase C 130 focal adhesion kinase 103 caspase-3 82 MEKK1 81 NO synthase 64 phosphatidylinositol 3-kinase 62 p100 55 AMP-activated protein kinase 50 glutathione S-transferase 42 calcineurin 42 caspase-8 42 PARP 41 peroxidase 34 phosphoinositide 3-kinase 33 NADPH oxidase 32 catalase 31 AMPK 30 AMPK 30 superoxide dismutase 30 MAP 29 NADPH oxidase 29 GSK 26 caspase-1 25 phospholipase C 20 caspase-9 16 collagenase 15 urokinase-type plasminogen activator 14 MIP 14 protein phosphatase 2A 13 RNA polymerase 13 PDK1 12 thrombin 12 NQO1 11 alanine aminotransferase 11 glutathione peroxidase 11 reverse transcriptase 9 lysozyme 9 creatine kinase 9 aspartate aminotransferase 9 cdc2 8 heme oxygenase 8 ECH 8 lactate dehydrogenase 8 NOS 8 ATPase 7 polo-like kinase 1 7 RNase 7 phosphodiesterase 7 P-glycoprotein 6 CaMKII 6 myosin light chain kinase 6 RNase 6 lipoxygenase 6 topoisomerase 6 ACS 6 MMP-3 6 acid phosphatase 6 topoisomerase 6 papain 5 phospholipase A2 5 alkaline phosphatase 5 AST 5 complex I 5 trypsin 5 ubiquitin-protein ligase 5 lipase 4 histone acetyltransferase 4 xanthine oxidase 4 caspase-11 4 phosphoenolpyruvate carboxykinase 4 succinate dehydrogenase 4 endonuclease 4 thioredoxin reductase 4 more...

Compound DNA 717 TNF 506 Dec 308 serine 224 oxygen 207 nitric oxide 148 lysine 105 glucose 103 tyrosine 98 threonine 87 Clin 82 MEK 74 AMP 72 acetate 69 alanine 56 sodium 54 cGMP 54 calcium 52 THP 52 cysteine 51 THP 51 ATP 51 PGE 46 MDA 39 PMA 37 PMA 36 hydrogen 36 water 34 GSH 33 GSH 33 ethanol 32 Curcumin 31 N-acetylcysteine 30 MAP 28 leucine 27 arginine 27 phosphate 26 cAMP 26 PGE2 26 pyrrolidine 24 retinoic acid 23 sulfate 23 pyrrolidine 22 GMP 21 1H-imidazole 21 Asp 21 MTT 20 H2O2 19 Insulin 18 RELA 17 zinc 17 NH2 16 TPCK 16 palmitic acid 14 iron 14 methionine 13 Phosphatidylinositol 13 Ubiquitin 12 nitrogen 12 ethyl acetate 12 ASA 12 GTP 12 TPA 11 Resveratrol 11 TPA 11 ATF 11 ASC 11 urea 11 Phe 10 creatinine 10 Serine 10 celastrol 10 palmitic acid 9 glutamate 9 Gly 9 galactose 9 chalcone 9 ADP 9 Celastrol 9 acetic acid 9 more...

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