Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:2.7.11.10 (IKK)
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Human Gene/Protein
transporter for antigen processing 1 12.7
G patch domain-containing protein 3 12.7
IKBKB protein 12.7
TBK1 12.7
IKBKB 12.7
CHUK 12.7
Parkinson disease (autosomal recessive, juvenile) 2, parkin 12.7
IKBKA 12.7
TMEM203 12.7
ZSWIM4 12.7
RAS-like GTPase 12.7
IFITM2 protein 12.7
FBXO18 12.7
peroxisomal biogenesis factor 3 12.7
TANK-binding kinase 1 12.7
IKK 12.7
IkappaB kinase 12.6
IKK epsilon 12.1
SIKE 12.0
AZI2 11.9
conserved helix-loop-helix ubiquitous kinase 11.9
SINTBAD 11.9
TANK protein 11.7
zinc finger protein 268 11.7
ZDHHC11 11.7
ADCK2 11.7
NAK-associated protein 1 11.7
ubiquitin specific peptidase 10 11.7
ASB8 11.7
TBC1 domain family member 9 11.7
LMTK2 protein 11.7
EID-2-like inhibitor of differentiation-3 11.7
TBC1 domain family member 15 11.7
ankyrin repeat and SOCS box-containing 8 11.7
TRAF family member-associated NF-kappa-B activator 11.7
coilin-interacting nuclear ATPase protein 11.7
G1/S-specific cyclin E2 11.7
IKK1 11.7
IKK2 11.4
IKK-interacting protein 11.3
more...
Disease
chronic tracheitis 9.2
CYLD 9.2
EDA-ID 9.1
Sendai virus infection 8.9
NEK1 8.8
VISA 8.5
Spring viremia of carp 7.9
ABC-DLBCL 7.9
Aortic calcification 7.9
incontinentia pigmenti 7.8
MODY4 7.7
Escherichia coli pneumonia 7.5
Hypertensive retinopathy 7.4
Hypertensive retinopathy 7.4
EBSS 7.1
viral keratitis 7.1
SPG11 6.9
FTD-ALS 6.8
Gram-positive bacterial infection 6.8
Cytokine storm 6.8
Epithelioma 6.6
viral arthritis 6.6
Papillary renal cell carcinoma 6.5
Other variants 6.3
AA1 6.2
Lumbar disc herniation 6.2
Cutaneous lupus erythematosus 6.1
low tension glaucoma 6.1
ectodermal dysplasia 6.1
Primary effusion lymphoma 6.1
Splenic marginal zone lymphoma 6.0
FUS 5.9
Herpes simplex encephalitis 5.9
Advanced cancer 5.9
Meconium aspiration syndrome 5.9
herpangina 5.9
Frontotemporal dementia 5.8
Oral infection 5.7
ALS2 5.7
PLAT 5.7
more...
Symptom
impaired motor coordination 5.1
bradypnea 5.0
Scratch 4.0
Decreased activity 3.6
swollen joints 3.6
cachexia 2.8
productive cough 2.5
Neuropathic pain 2.2
menopausal symptoms 2.0
starvation 2.0
memory loss 1.8
acute stress 1.5
dysuria 1.4
hyperoxia 1.3
hypothermia 1.2
polyuria 1.1
cancer pain 1.1
bone pain 1.1
cerebellar ataxia 0.8
diarrhea 0.8
apathy 0.7
erythema 0.6
splenomegaly 0.4
paresthesia 0.4
ataxia 0.3
insomnia 0.3
hepatomegaly 0.2
paresis 0.2
hypotonia 0.1
functional recovery -0.0
exhaustion -0.1
arthralgia -0.1
hypercapnia -0.3
collapse -0.6
dizziness -0.6
vomiting -0.7
nausea -0.9
fatigue -1.0
pain -1.0
overweight -1.0
more...
Drug
Pelubiprofen 11.1
Amlexanox 10.4
Ertiprotafib 10.3
E5564 7.5
Myotrophin 7.2
IFN-beta 6.8
Radicicol 6.6
Auranofin 6.6
TAK 6.4
Vesnarinone 6.4
Ciglitazone 6.4
RAL 6.3
Glybenclamide 6.0
Compound 16 6.0
Fluticasone propionate 5.8
Red ginseng 5.8
NAH 5.7
Febuxostat 5.5
Vinpocetine 5.5
Darunavir 5.4
Rebamipide 5.4
Rasagiline 5.4
Nitazoxanide 5.4
Ginger 5.4
3-Methyladenine 5.3
Artesunate 5.2
Salicylate 5.1
Dasatinib 5.0
BLyS 5.0
Parkin 5.0
Parkin 5.0
Bortezomib 4.7
Arsenic trioxide 4.7
CCL 4.7
ID2 4.5
Myricetin 4.4
K-252a 4.2
uPA 4.2
Fulvestrant 4.2
Glycyrrhiza 4.2
more...
Enzyme
IKK 12.7
phosphatidylinositol 3-phosphate 5-kinase 8.7
p100 8.6
MEKK1 8.1
HK3 7.9
STK4 7.2
GK2 7.2
aggrecanase-1 6.7
MHCK 6.6
diaminopimelate decarboxylase 6.5
octopine dehydrogenase 6.4
choline dehydrogenase 6.4
caspase-11 6.2
caspase-11 6.2
methylcrotonyl-CoA carboxylase 6.2
caspase-10 6.1
MEK 5.7
ECH 5.6
mitogen-activated protein kinase 5.6
GalT 5.5
7-dehydrocholesterol reductase 5.5
macrophage elastase 5.5
calpain 3 5.4
glycine N-methyltransferase 5.4
ubiquitin-protein ligase 5.3
caspase-8 5.3
proteasome 5.3
type 1 protein phosphatase 5.3
disulfide reductase 5.3
phosphoinositide 3-kinase 5.2
phosphatidylinositol 3-kinase 5.2
caspase-10 5.2
PDK1 5.1
GD3 synthase 5.1
AMPK 5.0
polo-like kinase 1 4.9
neutral sphingomyelinase 4.9
mu-calpain 4.8
protein phosphatase 2A 4.8
STK11 4.8
more...
Compound
C13H9ClFNO2 12.7
Robinin 10.3
Robinin 10.3
Humulone 10.1
Nodakenin 10.1
Ovatodiolide 9.8
Tylophorine 9.8
Ginkgolide C 9.7
Wedelolactone 9.6
Malabaricone C 9.3
Miltirone 9.2
Taraxerol 9.2
Taraxerol 9.2
Monotropein 9.2
DuP 697 9.1
Sulfuretin 9.0
Pachymic acid 8.9
Ginkgolide C 8.8
Humulone 8.6
Prunetin 8.5
Deoxyelephantopin 8.5
Isovitexin 8.3
Sarsasapogenin 8.3
Gramine 8.1
TPCK 8.1
Magnoflorine 8.1
Psoralidin 8.0
4-Thiouridine 8.0
Ginsenoside Re 7.9
Arctiin 7.9
Falcarindiol 7.9
Parthenolide 7.8
Eupatilin 7.8
Fangchinoline 7.7
2,6-dichloropyridine 7.7
Swertiamarin 7.7
Guggulsterone 7.7
Boswellic acid 7.6
Dihydromyricetin 7.6
Parthenolide 7.6
more...