Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:2.7.11.10 (IKK)
 4,900 document(s) hit in 31,850,051 MEDLINE articles (0.01 seconds) .

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Human Gene/Protein
G patch domain-containing protein 3 12.7
IKBKB protein 12.7
Parkinson disease (autosomal recessive, juvenile) 2, parkin 12.7
IFITM2 protein 12.7
ZSWIM4 12.7
CHUK 12.7
TBK1 12.7
TMEM203 12.7
RAS-like GTPase 12.7
TANK-binding kinase 1 12.7
peroxisomal biogenesis factor 3 12.7
transporter for antigen processing 1 12.7
FBXO18 12.7
IKBKA 12.7
IKBKB 12.7
IKK 12.7
IkappaB kinase 12.6
IKK epsilon 12.1
SIKE 12.0
conserved helix-loop-helix ubiquitous kinase 11.9
AZI2 11.9
SINTBAD 11.9
LMTK2 protein 11.7
ASB8 11.7
TRAF family member-associated NF-kappa-B activator 11.7
coilin-interacting nuclear ATPase protein 11.7
ankyrin repeat and SOCS box-containing 8 11.7
TBC1 domain family member 15 11.7
TANK protein 11.7
NAK-associated protein 1 11.7
ADCK2 11.7
TBC1 domain family member 9 11.7
EID-2-like inhibitor of differentiation-3 11.7
ZDHHC11 11.7
G1/S-specific cyclin E2 11.7
zinc finger protein 268 11.7
ubiquitin specific peptidase 10 11.7
IKK1 11.7
IKK2 11.4
IKK-interacting protein 11.3
TANK 11.3
MITA 11.1
SPTY2D1 11.1
serine/threonine kinase 24 11.1
Erbb2 interacting protein 11.1
wingless-type MMTV integration site family, member 1 11.1
TRAF3 interacting protein 2 11.1
RAB2A, member RAS oncogene family 11.1
TXBP151 11.1
TBC1D17 11.1
LPAL2 11.1
AP2 associated kinase 1 11.1
ZNF268 protein 11.1
LIPJ 11.1
OTUD2 11.1
IKBKE 11.0
IkappaBepsilon 11.0
NFkappaB essential modulator 10.9
Deltex4 10.9
NLRP4 10.7
NEMO 10.7
transportin 2 10.7
OSBPL8 10.7
ZF7 10.7
TXBP181 10.7
ATP-dependent RNA helicase DDX3X 10.7
SID1 transmembrane family member 2 10.7
CCL27 protein 10.7
Interleukin-1 receptor associated kinase-4 10.7
TMEM24 10.7
TNF receptor-associated factor 5 10.7
ZNF395 10.7
PLA1A 10.7
IRF3 10.6
IkappaBbeta 10.6
LMBR1 10.5
NIK 10.5
ERLIN1 10.5
XPOT 10.5
TRIM56 10.5
transforming growth factor-beta-activated kinase 1 10.4
transmembrane protein 59 10.3
BinCARD 10.3
TTLL12 10.3
RSRC2 10.3
NZF1 10.3
RNF128 10.3
REL protein 10.3
ZNF236 10.3
PTP-U2 10.3
calcium binding and coiled-coil domain 2 10.3
ZDHHC1 10.3
TAB2 10.3
RALB 10.3
mitogen-activated protein kinase kinase kinase 3 10.3
TAX1BP1 10.2
IkappaBalpha 10.2
TAK1-binding protein 1 10.2
TAB3 10.2
CARMA1 10.2
CHCHD10 10.1
LIPK 10.1
QTRT1 10.1
DEAD box protein 41 10.1
density-regulated protein 10.1
TRAF3-interacting protein 3 10.1
SAM domain- and HD domain-containing protein 1 10.1
TGF-beta-activated kinase 1 10.1
nucleosome assembly protein 1-like 1 10.1
FNTA 10.1
TAK1 10.0
TICAM1 10.0
Z-DNA binding protein 1 10.0
TRAF3 10.0
TRAF3IP3 10.0
interferon regulatory factor 3 9.9
Riplet 9.9
MYLK3 9.9
RPS3A 9.9
TFEB transcription factor 9.9
ROR-alpha 9.9
ABIN-2 9.9
FYVE-DSP1 9.9
FBXO27 9.9
MATII 9.9
IPO3 9.9
TAK1-binding protein 2 9.9
PRDM15 9.9
LRRC1 9.9
F2RL2 9.9
MAVS 9.9
IkappaB alpha 9.8
STING 9.8
MEKK3 9.8
Optineurin 9.8
MTND4 9.8
CARMA3 9.8
CISD2 9.7
TAB1 9.7
STX4 9.7
Tax1-binding protein 1 9.7
DIP2C 9.7
RC3H1 9.7
HECTD3 9.7
GALK2 9.7
USP38 9.7
LRRN3 9.7
PIGU 9.7
Lymphotoxin beta receptor 9.7
ARID5A 9.7
Jumonji domain-containing protein 8 9.7
LIMS2 9.7
Retinol dehydrogenase 9.7
YPEL5 9.7
UbcH2 9.7
EIF4EBP2 9.7
novel reductase 1 9.7
IGFL2 9.7
USP27X 9.7
DNAH10 9.7
more...
Disease
chronic tracheitis 9.2
CYLD 9.2
EDA-ID 9.1
Sendai virus infection 8.9
NEK1 8.8
VISA 8.5
Spring viremia of carp 7.9
ABC-DLBCL 7.9
Aortic calcification 7.9
incontinentia pigmenti 7.8
MODY4 7.7
Escherichia coli pneumonia 7.5
Hypertensive retinopathy 7.4
Hypertensive retinopathy 7.4
EBSS 7.1
viral keratitis 7.1
SPG11 6.9
FTD-ALS 6.8
Gram-positive bacterial infection 6.8
Cytokine storm 6.8
Epithelioma 6.6
viral arthritis 6.6
Papillary renal cell carcinoma 6.5
Other variants 6.3
AA1 6.2
Lumbar disc herniation 6.2
low tension glaucoma 6.1
Cutaneous lupus erythematosus 6.1
ectodermal dysplasia 6.1
Primary effusion lymphoma 6.1
Splenic marginal zone lymphoma 6.0
FUS 5.9
Herpes simplex encephalitis 5.9
Advanced cancer 5.9
Meconium aspiration syndrome 5.9
herpangina 5.9
Frontotemporal dementia 5.8
Oral infection 5.7
ALS2 5.7
PLAT 5.7
acute gastritis 5.6
FTLD 5.6
Chronic gastritis 5.6
Vesicular stomatitis 5.5
early disease onset 5.5
ocular herpes 5.5
familial dysautonomia 5.5
adult T-cell leukemia/lymphoma 5.4
Cancer cachexia 5.4
Psoriasis vulgaris 5.4
salivary gland cancer 5.4
lymphoblastoma 5.4
ISD 5.3
osteopoikilosis 5.3
sandfly fever 5.2
Primary open-angle glaucoma 5.1
FANCI 5.1
XFS 5.1
molluscum contagiosum 5.1
Primary immunodeficiency 5.0
US1 5.0
DRM 5.0
Lequesne 5.0
X-linked lymphoproliferative syndrome 5.0
Middle cerebral artery occlusion 5.0
primary lateral sclerosis 5.0
HOPS 4.9
Borna disease 4.9
virus infection 4.8
liver infection 4.8
B-cell neoplasm 4.8
HNSCC 4.8
CCL 4.7
Autosomal recessive polycystic kidney disease 4.7
multicentric Castleman's disease 4.6
inflammatory joint disease 4.6
skin tumor 4.6
overnutrition 4.6
stomatitis 4.6
Mixed infection 4.5
endotoxic shock 4.5
CIN 1 4.5
amyotrophic lateral sclerosis 4.5
DSS 4.5
SCD 4.5
rhinovirus infection 4.5
Silence 4.5
CIN 3 4.5
Parainfluenza 4.4
orf 4.4
EGC 4.4
NS3 4.4
hypertensive retinopathy 4.4
NOD 4.3
osteopetrosis 4.3
Blocking 4.3
Estrogen deficiency 4.3
Immune thrombocytopenia 4.3
GALT 4.3
malignant state 4.3
freckles 4.3
DSS 4.2
pancreatic fibrosis 4.2
Recruitment 4.2
metastatic ovarian cancer 4.2
Acute liver failure 4.2
African swine fever 4.2
MIP 4.2
Diabetic neuropathy 4.2
DBM 4.1
splenic marginal zone lymphoma 4.1
tumorigenesis 4.1
pseudogout 4.1
nasal allergy 4.1
uterine leiomyosarcoma 4.1
Tumour necrosis 4.1
mucosa-associated lymphoid tissue 4.0
EDA 4.0
PRRS 4.0
MODY 4.0
RSV infection 4.0
BCG infection 3.9
hypogammaglobulinemia 3.9
emerging infectious disease 3.9
Pfeiffer 3.9
Mastitis 3.9
NS2 3.9
vaginal infection 3.9
B-cell lymphoma 3.9
open angle glaucoma 3.8
CSE 3.8
MEN 2B 3.8
Kaposi's sarcoma 3.8
alcoholic pancreatitis 3.8
Myxoma 3.8
Rift Valley fever 3.8
latent infection 3.8
Crohn's colitis 3.8
HRS 3.8
chondrosarcoma 3.7
LMS 3.7
LMS 3.7
bacterial infection 3.7
squamous cell carcinoma of the skin 3.7
Persistent infection 3.7
Lyme arthritis 3.7
colitis 3.7
amebic colitis 3.7
anhidrosis 3.7
PARK2 3.7
cognitive disorder 3.7
Spencer 3.6
trichuriasis 3.6
protein deficiency 3.6
immune deficiency 3.6
Venezuelan equine encephalitis 3.6
juvenile myelomonocytic leukemia 3.6
XPF 3.6
CJD 3.6
B-cell lymphomas 3.6
more...
Symptom
impaired motor coordination 5.1
bradypnea 5.0
Scratch 4.0
Decreased activity 3.6
swollen joints 3.6
cachexia 2.8
productive cough 2.5
Neuropathic pain 2.2
menopausal symptoms 2.0
starvation 2.0
memory loss 1.8
acute stress 1.5
dysuria 1.4
hyperoxia 1.3
hypothermia 1.2
polyuria 1.1
cancer pain 1.1
bone pain 1.1
cerebellar ataxia 0.8
diarrhea 0.8
apathy 0.7
erythema 0.6
splenomegaly 0.4
paresthesia 0.4
ataxia 0.3
insomnia 0.3
hepatomegaly 0.2
paresis 0.2
hypotonia 0.1
functional recovery -0.0
exhaustion -0.1
arthralgia -0.1
hypercapnia -0.3
collapse -0.6
dizziness -0.6
vomiting -0.7
nausea -0.9
fatigue -1.0
pain -1.0
overweight -1.0
anorexia -1.1
analgesia -1.1
weakness -1.5
angina -1.7
cough -1.9
seizures -3.6
anesthesia -4.1
Drug
Pelubiprofen 11.1
Amlexanox 10.4
Ertiprotafib 10.3
E5564 7.5
Myotrophin 7.2
IFN-beta 6.8
Radicicol 6.6
Auranofin 6.6
TAK 6.4
Vesnarinone 6.4
Ciglitazone 6.4
RAL 6.3
Glybenclamide 6.0
Compound 16 6.0
Fluticasone propionate 5.8
Red ginseng 5.8
NAH 5.7
Febuxostat 5.5
Vinpocetine 5.5
Darunavir 5.4
Rebamipide 5.4
Rasagiline 5.4
Nitazoxanide 5.4
Ginger 5.4
3-Methyladenine 5.3
Artesunate 5.2
Salicylate 5.1
Dasatinib 5.0
BLyS 5.0
Parkin 5.0
Parkin 5.0
Bortezomib 4.7
Arsenic trioxide 4.7
CCL 4.7
ID2 4.5
Myricetin 4.4
K-252a 4.2
uPA 4.2
Fulvestrant 4.2
Glycyrrhiza 4.2
IL-11 4.1
Retinoic acid 4.1
CIA 4.0
ROS 4.0
Rosiglitazone 4.0
Epigallocatechin 3.9
Moxifloxacin 3.8
Emodin 3.8
Dihydro 3.6
Taxol 3.6
Troglitazone 3.6
Simvastatin 3.6
p75 3.5
Papain 3.5
MAP 3.5
GHRP 3.5
Emodin 3.5
CPM 3.5
Gefitinib 3.4
Imatinib 3.4
Taxotere 3.4
Budesonide 3.4
R1881 3.4
Kainic acid 3.3
IL-2 3.2
Heme 3.1
TEL 3.1
TAT 3.0
Ginseng 3.0
lysine 2.9
Gelatin 2.9
Docetaxel 2.9
APD 2.8
DEX 2.8
Alanine 2.8
Fructose 2.8
IFN-gamma 2.7
Acyclovir 2.6
CTC 2.6
Doxycycline 2.6
Herceptin 2.5
RFP 2.4
Azithromycin 2.4
Fentanyl 2.3
CTC 2.3
ETS 2.3
IL-1ra 2.2
ALA 2.2
CTA 2.2
Gleevec 2.2
IPM 2.1
balanced salt solution 2.1
Angiotensin II 1.9
MRC 1.9
Award 1.9
Norplant 1.9
Bevacizumab 1.9
Glutathione 1.9
TTC 1.8
Fluorescein 1.8
CSF 1.7
Itraconazole 1.7
Propofol 1.6
Captopril 1.5
Gel 1.4
pyridoxal phosphate 1.4
Fraction 1.3
Nitric Oxide 1.3
G-CSF 1.3
Alliance 1.3
Rituximab 1.2
Indomethacin 1.0
Asn 0.7
Portal 0.6
vitamin E 0.6
ascorbate 0.5
Asthma 0.3
CTX 0.2
CTX 0.2
EPA -0.1
ROC -0.3
DNase I -0.4
ABC -0.4
Ethanol -0.6
CTX -0.6
TiO2 -0.8
Monit -0.8
Dermatol -1.6
caffeine -1.7
NADH -1.8
Cardiovasc -3.4
Enzyme
IKK 12.7
phosphatidylinositol 3-phosphate 5-kinase 8.7
p100 8.6
MEKK1 8.1
HK3 7.9
STK4 7.2
GK2 7.2
aggrecanase-1 6.7
MHCK 6.6
diaminopimelate decarboxylase 6.5
octopine dehydrogenase 6.4
choline dehydrogenase 6.4
caspase-11 6.2
caspase-11 6.2
methylcrotonyl-CoA carboxylase 6.2
caspase-10 6.1
MEK 5.7
ECH 5.6
mitogen-activated protein kinase 5.6
GalT 5.5
7-dehydrocholesterol reductase 5.5
macrophage elastase 5.5
calpain 3 5.4
glycine N-methyltransferase 5.4
ubiquitin-protein ligase 5.3
caspase-8 5.3
proteasome 5.3
type 1 protein phosphatase 5.3
disulfide reductase 5.3
phosphoinositide 3-kinase 5.2
phosphatidylinositol 3-kinase 5.2
caspase-10 5.2
PDK1 5.1
GD3 synthase 5.1
AMPK 5.0
polo-like kinase 1 4.9
neutral sphingomyelinase 4.9
mu-calpain 4.8
protein phosphatase 2A 4.8
STK11 4.8
luciferase 4.7
3C protease 4.7
NO synthase 4.7
lysyl hydroxylase 4.7
sphingosine kinase 4.7
caspase-1 4.7
MAP 4.7
GSK 4.6
AMP-activated protein kinase 4.6
HK2 4.5
meprin 4.5
GRK2 4.5
protein kinase 4.4
dimethylarginine dimethylaminohydrolase 4.4
PARP 4.3
ceramidase 4.3
MIP 4.2
NADPH oxidase 4.2
NADPH oxidase 4.2
guanylate kinase 4.2
TOR 4.1
protein kinase C 4.1
caspase-2 4.1
ERK 4.1
TACE 4.0
caspase-2 4.0
calcineurin 4.0
AMPK 4.0
focal adhesion kinase 3.9
Protein 2 3.9
calpain 3 3.9
caspase-3 3.9
CGT 3.9
caspase-7 3.9
myosin light chain kinase 3.9
caspase-7 3.8
caspase-9 3.8
caspase-6 3.8
gamma-glutamylcysteine synthetase 3.8
glucosylceramide synthase 3.8
caspase-6 3.7
O-GlcNAc transferase 3.7
phosphoribulokinase 3.6
heme oxygenase 3.6
CYP27A1 3.6
glutathione S-transferase 3.6
thromboxane synthase 3.5
NQO1 3.5
MMP-3 3.5
myrosinase 3.5
PI-PLC 3.5
thioredoxin reductase 3.4
factor C 3.4
GTP cyclohydrolase I 3.3
BAL 3.3
CaMKII 3.3
CPM 3.3
phosphatidylinositol 4-kinase 3.3
histone acetyltransferase 3.2
chaperonin 3.2
matrix metalloproteinase 9 3.1
cytosine deaminase 3.1
chalcone synthase 3.1
urokinase-type plasminogen activator 3.1
AGT 3.1
matrix metalloproteinase 2 3.1
peptidyl-prolyl cis-trans isomerase 3.1
TAT 3.0
12-lipoxygenase 2.9
beta-secretase 2.9
prolyl hydroxylase 2.8
NOS 2.8
phospholipase C 2.8
firefly luciferase 2.8
adenosine kinase 2.8
MPP 2.8
interstitial collagenase 2.8
cdc2 2.6
farnesyltransferase 2.6
aldose reductase 2.6
3-hydroxy-3-methylglutaryl-CoA reductase 2.5
GRK5 2.5
15-lipoxygenase 2.5
phosphoenolpyruvate carboxykinase 2.5
TSA 2.4
AST 2.4
collagenase 2.4
arginase 2.4
PKG 2.4
SPC 2.3
papain 2.3
MDP 2.3
phosphoenolpyruvate carboxykinase 2.2
phosphoenolpyruvate carboxykinase 2.2
PGM 2.2
MMP 2.2
acetyl-CoA carboxylase 2.2
lipoxygenase 2.2
glucocerebrosidase 2.1
farnesyltransferase 2.1
pyruvate carboxylase 2.1
topoisomerase 2.1
triphosphatase 2.1
glucose-6-phosphatase 2.1
leucine aminopeptidase 2.0
topoisomerase 2.0
dipeptidyl peptidase IV 2.0
AOR 1.9
tryptophan hydroxylase 1.9
complex I 1.9
catalase 1.9
PDE 1.8
cathepsin K 1.8
PRE 1.8
peroxidase 1.8
DCF 1.7
superoxide dismutase 1.7
cathepsin L 1.7
glutathione peroxidase 1.7
succinate dehydrogenase 1.7
more...
Compound
C13H9ClFNO2 12.7
Robinin 10.3
Robinin 10.3
Nodakenin 10.1
Humulone 10.1
Tylophorine 9.8
Ovatodiolide 9.8
Ginkgolide C 9.7
Wedelolactone 9.6
Malabaricone C 9.3
Miltirone 9.2
Monotropein 9.2
Taraxerol 9.2
Taraxerol 9.2
DuP 697 9.1
Sulfuretin 9.0
Pachymic acid 8.9
Ginkgolide C 8.8
Humulone 8.6
Prunetin 8.5
Deoxyelephantopin 8.5
Isovitexin 8.3
Sarsasapogenin 8.3
Gramine 8.1
TPCK 8.1
Magnoflorine 8.1
Psoralidin 8.0
4-Thiouridine 8.0
Ginsenoside Re 7.9
Falcarindiol 7.9
Arctiin 7.9
Parthenolide 7.8
Eupatilin 7.8
Guggulsterone 7.7
Swertiamarin 7.7
2,6-dichloropyridine 7.7
Fangchinoline 7.7
Dihydromyricetin 7.6
Boswellic acid 7.6
Parthenolide 7.6
Celastrol 7.5
Iturin A 7.4
Butein 7.3
RELA 7.2
Gambogic acid 7.2
Withaferin A 7.2
Daphnetin 7.0
Carnosic acid 7.0
Pristimerin 6.9
Ginkgolide B 6.9
Pristimerin 6.9
Flavone acetic acid 6.9
Pristimerin 6.9
Pristimerin 6.9
Alantolactone 6.9
HFr 6.8
Bergenin 6.8
CUE 6.8
Diosmetin 6.7
Digitoxin 6.7
Acacetin 6.7
Carnosol 6.6
Cryptoxanthin 6.6
celastrol 6.6
1-heptene 6.6
Benznidazole 6.6
Benznidazole 6.6
Benznidazole 6.6
3-cyanopyridine 6.6
pentyl acetate 6.6
Garcinol 6.6
Glabridin 6.5
thieno[2,3-b]pyridine 6.5
4-hydroxy-3-methoxybenzaldehyde 6.5
4-hydroxy-3-methoxybenzaldehyde 6.5
Tangeretin 6.5
PRD 6.5
Chrysin 6.4
Surfactin 6.4
Manumycin 6.4
Zingerone 6.4
9Z,11E-octadecadienoic acid 6.4
Lipoxin A4 6.4
Pinocembrin 6.4
Deguelin 6.4
Mimosine 6.3
cephalotaxine 6.3
Salina 6.3
1H-imidazole 6.3
Poly(I:C) 6.2
3-aminobenzoic acid 6.2
Mimosine 6.2
Punicalagin 6.2
cephalotaxine 6.2
Sterigmatocystin 6.2
Piceatannol 6.2
Pterostilbene 6.2
Noscapine 6.1
Emetine 6.1
(S)-4-carboxyphenylglycine 6.1
Tyrosol 6.1
4-hydroxy-3-methoxybenzaldehyde 6.0
DMU 6.0
DMU 6.0
DMSP 5.9
NIX 5.9
DFD 5.9
EPC 5.9
CeCl3 5.8
Fenvalerate 5.8
Ethyl pyruvate 5.8
Embelin 5.8
2-butenal 5.8
Phenethyl isothiocyanate 5.8
PTAP 5.8
Oltipraz 5.8
Asiatic acid 5.8
Mangiferin 5.8
Zinc protoporphyrin 5.8
Rottlerin 5.8
TNF 5.7
Caffeic acid phenethyl ester 5.7
Arsenite 5.7
Mangostin 5.7
DMU 5.7
Poly I 5.7
Geldanamycin 5.7
Cinnamaldehyde 5.7
Norharman 5.7
Rottlerin 5.7
Rottlerin 5.6
Taxifolin 5.6
Formononetin 5.6
Sulfatide 5.6
Rhein 5.6
Evodiamine 5.6
Luteolin 5.6
Delphinidin 5.6
AY9944 5.6
Biochanin A 5.5
LY 294002 5.5
Evodiamine 5.5
PGJ2 5.5
Sinomenine 5.5
Paeoniflorin 5.5
Apigenin 5.4
NaAsO2 5.4
6-Gingerol 5.4
Sulfasalazine 5.4
benzenesulfonyl fluoride 5.4
Naringin 5.4
Honokiol 5.4
Acteoside 5.3
EOC 5.3
20-HETE 5.3
Isoliquiritigenin 5.3
3-Methyladenine 5.3
Triptolide 5.3
Paeonol 5.3
Desflurane 5.2
more...