Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:2.7.11.10 (IKK)
 4,900 document(s) hit in 31,850,051 MEDLINE articles (0.01 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
IKK 2478
IkappaB kinase 1468
TBK1 766
p65 755
Mol 564
cytokine 554
TNF 506
IkappaBalpha 499
tumor necrosis factor 473
interferon 422
lipopolysaccharide 348
IL-6 339
IFN 334
p38 330
Sep 321
IRF3 318
TANK-binding kinase 1 314
JNK 289
NEMO 269
ubiquitin 267
LPS 257
MAPK 225
TLR4 217
inducible nitric oxide synthase 210
TNF-alpha 198
RIG-I 179
STING 179
IL-8 177
p50 174
ERK 173
proteasome 172
TAK1 152
TRAF6 151
insulin 148
IKK2 147
MyD88 146
AP-1 145
type I interferon 144
interferon regulatory factor 3 141
tumor necrosis factor alpha 136
IL-1 136
PI3K 132
cyclooxygenase-2 130
c-Jun 113
COX-2 112
AKT 112
caspase-3 110
TRAF2 109
ERK1 106
p53 105
IKBKB 104
Bcl-2 104
IKK1 96
TANK 95
MAVS 95
chemokine 95
interleukin-6 95
mitogen-activated protein 89
NIK 86
TNF receptor 84
TLR3 83
Ubiquitin 82
adaptor protein 82
TRIF 81
MEK 81
extracellular signal-regulated kinase 77
TRAF3 75
mTOR 75
nitric oxide synthase 73
AMP 71
IL-10 66
ICAM-1 65
IRF7 64
IFN-beta 62
phosphatidylinositol 3-kinase 62
p52 62
A20 61
endoplasmic reticulum 61
E3 ubiquitin ligase 61
cyclin D1 59
IkappaBbeta 58
PKC 58
TLR2 57
STAT3 57
threonine 56
p100 55
RANTES 54
CD4 53
caspase-8 52
phosphatase 52
ATP 51
THP 51
CHUK 50
vascular cell adhesion molecule-1 50
tumor necrosis factor receptor 50
ROS 49
p38 mitogen-activated protein kinase 49
interacting protein 49
MCP-1 47
phosphorylating 47
tyrosine kinase 46
lymphoid 46
ubiquitin ligase 46
serine/threonine kinase 45
CD40 45
p62 45
Cytokine 45
p105 45
STAT 45
cyclooxygenase 44
matrix metalloproteinase 44
IP1 43
MDA5 43
MEKK 42
IL-2 42
collagen 41
cIAP2 40
CD28 40
c-Rel 40
proteasome inhibitor 39
MALT1 39
MEK1 39
PARP 38
RANKL 38
RIP 38
carp 38
MMP-9 38
RIPK1 38
TLR9 38
VEGF 37
histone 36
IkappaB alpha 36
PDB 36
p21 35
XIAP 35
STAT1 35
MEKK1 35
Tumor necrosis factor 35
RIP1 35
vascular endothelial growth factor 35
IRS-1 34
TCR 34
p300 34
optineurin 34
JNK1 34
LC3 34
adhesion molecule 33
phosphoinositide 3-kinase 33
IRAK-1 33
CYLD 32
leucine zipper 32
TAB2 32
myeloperoxidase 31
MITA 31
GSH 31
Fas 30
IFN-gamma 30
AMPK 30
TNFR1 30
IKBKE 30
more...
Disease
cancer 726
tumor 433
virus infection 215
tumorigenesis 152
breast cancer 120
leukemia 100
obesity 96
rheumatoid arthritis 85
carcinogenesis 78
diabetes 78
hepatocellular carcinoma 69
amyotrophic lateral sclerosis 67
tumor progression 64
tumor growth 57
lymphoma 55
arthritis 53
ischemia 53
prostate cancer 53
sepsis 52
atherosclerosis 51
type 2 diabetes 51
immunodeficiency 50
sepsis 49
melanoma 49
carcinoma 48
influenza 46
lung cancer 43
herpes simplex 42
infectious diseases 41
asthma 39
colitis 39
HIV 38
multiple myeloma 38
B-cell lymphoma 37
dementia 37
MCF 36
adenocarcinoma 33
hepatitis C 33
Alzheimer's disease 33
stomatitis 32
GSH 31
bacterial infection 31
Parkinson's disease 30
pancreatic cancer 29
osteoarthritis 29
CYLD 29
Mycobacterium 29
Blocking 28
inflammatory bowel disease 28
Epstein 25
colon cancer 25
Hodgkin's disease 25
hyperglycemia 24
ovarian cancer 23
squamous cell carcinoma 23
colorectal cancer 23
dermatitis 23
autoimmune disease 22
systemic lupus erythematosus 22
chronic obstructive pulmonary disease 22
tuberculosis 22
Infection 21
hepatitis B 21
glioma 21
NOD 21
ATM 21
cytomegalovirus 20
stroke 19
Kaposi's sarcoma 19
acute myeloid leukemia 19
VISA 19
hepatitis 19
cardiovascular disease 19
incontinentia pigmenti 18
glaucoma 18
metastases 17
adult T-cell leukemia/lymphoma 17
cerebral ischemia 17
osteoporosis 17
heart failure 16
gastric cancer 16
ectodermal dysplasia 16
cervical cancer 16
hypertension 16
vaccinia 16
skin cancer 15
liver cancer 15
non-small cell lung cancer 15
glioblastoma 15
metabolic syndrome 14
multiple sclerosis 14
myocardial ischemia 14
Huntington's disease 14
Sendai virus infection 14
fatty liver 14
MIP 14
encephalomyelitis 14
viremia 13
psoriasis 13
liver cancer 13
gastritis 12
SARS 12
osteosarcoma 12
type 1 diabetes 12
plaque 12
cystic fibrosis 11
SCID 11
chronic myeloid leukemia 11
FUS 11
Crohn's disease 11
malnutrition 11
ulcerative colitis 11
NS3 11
cirrhosis 11
solid tumor 10
Yersinia 10
liver fibrosis 10
chronic lymphocytic leukemia 10
vascular disease 10
periodontitis 10
thrombocytopenia 10
AIDS 9
Recruitment 9
chondrosarcoma 9
mucosa-associated lymphoid tissue 9
muscular atrophy 8
blindness 8
pertussis 8
anemia 8
Newcastle disease 8
primary tumor 8
neuroblastoma 8
liver disease 8
herpes 8
lung carcinoma 8
chronic lymphocytic leukemia 8
cold 8
acute lymphoblastic leukemia 7
B-cell lymphomas 7
diabetic retinopathy 7
malaria 7
skin tumor 7
glucose intolerance 7
latent infection 7
leukemogenesis 7
West 7
neoplastic transformation 7
encephalitis 7
retinoblastoma 7
anaphylaxis 7
FAS 7
myocardial infarction 7
PHA 7
Helicobacter pylori infection 7
EBV infection 7
immune deficiency 7
myocarditis 7
genetic disorder 6
renal disease 6
hyperinsulinemia 6
more...
Symptom
pain 20
starvation 15
diarrhea 15
cachexia 6
hypothermia 6
fatigue 4
collapse 3
erythema 3
vomiting 3
ataxia 3
weakness 2
splenomegaly 2
overweight 2
acute stress 2
analgesia 2
nausea 2
insomnia 2
memory loss 2
functional recovery 2
hyperoxia 2
exhaustion 2
anesthesia 1
cough 1
dysuria 1
Neuropathic pain 1
productive cough 1
angina 1
paresis 1
apathy 1
hypotonia 1
paresthesia 1
anorexia 1
cerebellar ataxia 1
Scratch 1
polyuria 1
dizziness 1
hepatomegaly 1
bone pain 1
swollen joints 1
impaired motor coordination 1
hypercapnia 1
seizures 1
Decreased activity 1
cancer pain 1
menopausal symptoms 1
bradypnea 1
arthralgia 1
Drug
lysine 68
IFN-beta 52
ROS 49
IL-2 42
MAP 28
IFN-gamma 28
CSF 16
Dermatol 13
TAK 13
Retinoic acid 9
Parkin 9
Amlexanox 9
Parkin 9
p75 7
Bortezomib 6
Taxol 6
Gel 6
uPA 6
Arsenic trioxide 5
Asthma 5
Auranofin 5
ascorbate 5
CCL 5
vitamin E 4
Imatinib 4
Glycyrrhiza 4
Heme 4
Ginger 3
TAT 3
Salicylate 3
Monit 3
Glutathione 3
Dasatinib 3
IL-11 3
Simvastatin 3
Cardiovasc 3
RAL 3
Alanine 3
Angiotensin II 3
Asn 3
MRC 2
Ginseng 2
ETS 2
Rosiglitazone 2
Herceptin 2
CIA 2
Fluorescein 2
Gefitinib 2
Docetaxel 2
Indomethacin 2
Fructose 2
Gelatin 2
ALA 2
G-CSF 2
Artesunate 2
Captopril 1
APD 1
Kainic acid 1
Rebamipide 1
EPA 1
CTA 1
GHRP 1
NADH 1
ID2 1
ABC 1
Vinpocetine 1
pyridoxal phosphate 1
Alliance 1
CTC 1
Moxifloxacin 1
Bevacizumab 1
Compound 16 1
Budesonide 1
balanced salt solution 1
K-252a 1
TEL 1
IPM 1
DEX 1
Azithromycin 1
Propofol 1
DNase I 1
ROC 1
CTX 1
Darunavir 1
Portal 1
Radicicol 1
Ciglitazone 1
NAH 1
Rituximab 1
Glybenclamide 1
Pelubiprofen 1
Fluticasone propionate 1
R1881 1
Ertiprotafib 1
Ethanol 1
CTX 1
BLyS 1
Norplant 1
TTC 1
Nitazoxanide 1
Myotrophin 1
Award 1
CTC 1
CTX 1
Febuxostat 1
Myricetin 1
Taxotere 1
Doxycycline 1
Epigallocatechin 1
Gleevec 1
Acyclovir 1
Fentanyl 1
Nitric Oxide 1
caffeine 1
Papain 1
Fraction 1
CPM 1
Itraconazole 1
3-Methyladenine 1
IL-1ra 1
Red ginseng 1
Emodin 1
Vesnarinone 1
TiO2 1
Fulvestrant 1
Emodin 1
Dihydro 1
E5564 1
Rasagiline 1
RFP 1
Troglitazone 1
Enzyme
IKK 4900
mitogen-activated protein kinase 725
protein kinase 269
ERK 245
proteasome 175
luciferase 157
MEK 149
protein kinase C 130
focal adhesion kinase 103
caspase-3 82
MEKK1 81
NO synthase 64
phosphatidylinositol 3-kinase 62
p100 55
AMP-activated protein kinase 50
glutathione S-transferase 42
caspase-8 42
calcineurin 42
PARP 41
peroxidase 34
phosphoinositide 3-kinase 33
NADPH oxidase 32
catalase 31
superoxide dismutase 30
AMPK 30
AMPK 30
NADPH oxidase 29
MAP 29
GSK 26
caspase-1 25
phospholipase C 20
caspase-9 16
collagenase 15
MIP 14
urokinase-type plasminogen activator 14
protein phosphatase 2A 13
RNA polymerase 13
PDK1 12
thrombin 12
glutathione peroxidase 11
NQO1 11
alanine aminotransferase 11
reverse transcriptase 9
aspartate aminotransferase 9
lysozyme 9
creatine kinase 9
cdc2 8
NOS 8
heme oxygenase 8
ECH 8
lactate dehydrogenase 8
ATPase 7
RNase 7
phosphodiesterase 7
polo-like kinase 1 7
lipoxygenase 6
CaMKII 6
myosin light chain kinase 6
RNase 6
topoisomerase 6
ACS 6
acid phosphatase 6
topoisomerase 6
MMP-3 6
P-glycoprotein 6
complex I 5
ubiquitin-protein ligase 5
phospholipase A2 5
alkaline phosphatase 5
AST 5
trypsin 5
papain 5
caspase-11 4
phosphoenolpyruvate carboxykinase 4
lipase 4
xanthine oxidase 4
thioredoxin reductase 4
endonuclease 4
succinate dehydrogenase 4
TOR 4
caspase-11 4
histone acetyltransferase 4
aldose reductase 3
transcriptase 3
mu-calpain 3
firefly luciferase 3
gamma-glutamylcysteine synthetase 3
phosphoenolpyruvate carboxykinase 3
phosphoenolpyruvate carboxykinase 3
matrix metalloproteinase 9 3
matrix metalloproteinase 2 3
glutathione reductase 3
arginase 3
sphingosine kinase 3
neutral sphingomyelinase 3
chaperonin 3
TAT 3
renin 3
adenylate cyclase 3
MMP 3
beta-galactosidase 3
BAL 3
GRK2 3
3C protease 2
DNA methyltransferase 2
caspase-2 2
DNA polymerase 2
DNase 2
caspase-7 2
caspase-10 2
MDP 2
MPP 2
caspase-7 2
GalT 2
STK11 2
APC 2
HK2 2
prolyl hydroxylase 2
disulfide reductase 2
cathepsin D 2
glucose-6-phosphatase 2
glucose-6-phosphate dehydrogenase 2
SPC 2
chalcone synthase 2
meprin 2
PDE 2
TACE 2
elastase 2
guanylate cyclase 2
acetyl-CoA carboxylase 2
PKG 2
caspase-2 2
CYP3A4 2
ACE 2
GRK5 1
monoamine oxidase 1
cathepsin K 1
glutamine synthetase 1
Protein 2 1
GD3 synthase 1
triphosphatase 1
phosphoribulokinase 1
CPM 1
deaminase 1
octopine dehydrogenase 1
ribonuclease 1
calpain 3 1
farnesyltransferase 1
phosphatidylinositol 4-kinase 1
caspase-6 1
tryptase 1
farnesyltransferase 1
thromboplastin 1
STR 1
glucokinase 1
peroxiredoxin 1
dihydrofolate reductase 1
ATP synthase 1
PRE 1
STK4 1
more...
Compound
DNA 717
TNF 506
Dec 308
serine 224
oxygen 207
nitric oxide 148
lysine 105
glucose 103
tyrosine 98
threonine 87
Clin 82
MEK 74
AMP 72
acetate 69
alanine 56
sodium 54
cGMP 54
calcium 52
THP 52
ATP 51
cysteine 51
THP 51
PGE 46
MDA 39
PMA 37
hydrogen 36
PMA 36
water 34
GSH 33
GSH 33
ethanol 32
Curcumin 31
N-acetylcysteine 30
MAP 28
leucine 27
arginine 27
cAMP 26
PGE2 26
phosphate 26
pyrrolidine 24
sulfate 23
retinoic acid 23
pyrrolidine 22
Asp 21
GMP 21
1H-imidazole 21
MTT 20
H2O2 19
Insulin 18
RELA 17
zinc 17
TPCK 16
NH2 16
iron 14
palmitic acid 14
Phosphatidylinositol 13
methionine 13
Ubiquitin 12
ethyl acetate 12
GTP 12
nitrogen 12
ASA 12
Resveratrol 11
TPA 11
TPA 11
ATF 11
ASC 11
urea 11
creatinine 10
Phe 10
Serine 10
celastrol 10
chalcone 9
Celastrol 9
acetic acid 9
glutamate 9
galactose 9
ADP 9
palmitic acid 9
Gly 9
Paclitaxel 8
salicylic acid 8
ADP 8
NADPH 8
BCR 8
NADPH 8
Panam 8
NAD 8
Quercetin 8
ADP 8
kaempferol 8
TEM 8
NAD 7
His 7
Parthenolide 7
isoquinoline 7
copper 7
dUTP 7
ADP-ribose 7
salt 7
Ang II 7
Parthenolide 7
GSSG 7
ACS 6
Poly I 6
pyridine 6
proline 6
Cardiol 6
CAT 6
CAT 6
ADR 6
Cereb 6
ACS 6
EPC 6
Optimal 6
adenosylmethionine 6
CAT 6
Adriamycin 6
PAM 5
aspartic acid 5
anthracene 5
aldehyde 5
aspartic acid 5
HCl 5
DSS 5
Luteolin 5
Piper 5
TNM 5
Arsenite 5
ABL 5
CO2 5
Berberine 5
boron 5
glutamine 5
Apigenin 5
aspartic acid 5
Poly(I:C) 5
nicotinamide 5
COS 5
Angiotensin II 5
ammonium 5
NKT 5
FK506 5
Cbl 5
aspartic acid 5
Dihydromyricetin 4
Adenine 4
Dexamethasone 4
GDP 4
Wedelolactone 4
Thrombin 4
indole-3-carbinol 4
tryptophan 4
Guo 4
aldehyde 4
SDS 4
pyrimidine 4
diacetate 4
Withaferin A 4
titanium 4
more...