Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:2.7.11.10 (
IKK
)
4,900
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
TANK-binding kinase 1
(
TBK1
) is central to multiple biological processes that promote tumorigenesis including cell division, autophagy, innate immune response and AKT-pro survival signaling.
TBK1
is well studied and most known for its function in innate immunity. However, the
serine threonine protein kinase
received significant attention as a synthetic lethal partner and effector of the major oncogene, RAS. This review summarizes newly identified cancer promoting functions of
TBK1
and evaluates the therapeutic potential of targeting
TBK1
in cancer.
...
PMID:Assessment of TANK-binding kinase 1 as a therapeutic target in cancer. 2921 56
