Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:2.7.11.1 (protein kinase)
81,284 document(s) hit in 31,850,051 MEDLINE articles (0.05 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
Mol 9771
PKA 7170
cAMP-dependent protein kinase 6110
Sep 5579
ATP 5558
cyclin-dependent kinase 5526
AMP 4657
calmodulin 4655
insulin 3614
PKC 2823
threonine 2769
p38 2649
phosphatase 2575
cyclin 2417
MAPK 2416
ERK1 2317
Raf-1 2269
ERK 2153
PKG 2086
adenylate cyclase 1999
p21 1826
GSK 1802
p53 1789
serine/threonine protein kinase 1789
phosphodiesterase 1750
adenylyl cyclase 1703
MEK 1702
tyrosine kinase 1672
mTOR 1578
cytokine 1537
endoplasmic reticulum 1527
caspase-3 1371
protein phosphatase 1363
AKT 1331
GTP 1324
CK2 1323
mitogen-activated protein 1321
extracellular signal-regulated kinase 1307
phosphatidylinositol 3-kinase 1279
casein kinase 1261
histone 1230
c-Jun 1212
CREB 1208
polypeptide 1197
phosphorylating 1191
ATPase 1185
p27 1173
MAP kinase 1156
protein kinase B 1148
Rho 1122
phosphoprotein 1119
PI3K 1086
cyclin D1 1062
interferon 1037
casein 1031
catenin 1028
PKR 1005
JNK 990
Bcl-2 938
tumor necrosis factor 934
epidermal growth factor 867
proteasome 843
ubiquitin 829
lipopolysaccharide 802
nitric oxide synthase 793
serine/threonine kinase 757
CaMKII 733
protein kinase inhibitor 719
collagen 704
glucagon 702
TNF 696
AMPK 690
ADP 659
SDS 653
AMP-activated protein kinase 651
calcineurin 650
phosphoinositide 3-kinase 644
CDK2 615
MEK1 614
alkaline phosphatase 610
more...
Disease
cancer 6994
tumor 5111
Alzheimer's disease 1533
diabetes 1509
breast cancer 1289
tumorigenesis 1098
ischemia 924
pertussis 867
hepatocellular carcinoma 839
obesity 834
retinoblastoma 825
carcinoma 823
leukemia 802
depression 775
tumor growth 765
heart failure 673
SDS 653
carcinogenesis 645
melanoma 628
type 2 diabetes 619
hypertension 602
neuroblastoma 584
prostate cancer 523
ATM 512
tumor progression 507
Parkinson's disease 507
MCF 503
cholera 498
atherosclerosis 453
virus infection 443
lung cancer 428
lymphoma 421
glioma 407
hyperglycemia 397
HIV 383
colon cancer 382
adenocarcinoma 365
colorectal cancer 363
stroke 360
cold 343
herpes simplex 336
squamous cell carcinoma 279
pheochromocytoma 277
cystic fibrosis 273
immunodeficiency 268
asthma 264
cognitive impairment 263
NAME 260
Blocking 255
metastases 250
osteosarcoma 230
cardiovascular disease 227
cytomegalovirus 224
gastric cancer 223
ovarian cancer 217
cerebral ischemia 215
glioblastoma 215
myocardial infarction 212
dementia 209
fatty liver 203
schizophrenia 202
sarcoma 200
B-cell lymphoma 198
GSH 195
vaccinia 193
Rous sarcoma 192
infectious diseases 186
hepatitis C 182
chronic myeloid leukemia 181
myocardial ischemia 179
non-small cell lung cancer 178
acute myeloid leukemia 176
multiple myeloma 176
pancreatic cancer 175
bipolar disorder 174
malaria 170
PDE 170
sepsis 170
sepsis 166
APC 165
more...
Symptom
pain 609
starvation 546
seizures 147
collapse 118
diarrhea 93
functional recovery 72
anesthesia 70
ataxia 63
fatigue 60
analgesia 53
rundown 48
memory loss 42
weakness 41
exhaustion 35
hypothermia 35
respiratory distress 27
hyperoxia 25
acute stress 25
cachexia 24
overweight 24
acidity 22
stigma 21
Neuropathic pain 20
anorexia 20
cerebellar ataxia 19
vomiting 18
acute pain 17
tremor 17
hypercapnia 16
splenomegaly 15
polyuria 15
skin damage 15
headache 12
nausea 11
angina 11
thinning 11
erythema 11
Anoxia 10
constipation 10
hypotonia 10
HSA 9
hepatomegaly 9
despair 8
hunger 8
bradykinesia 7
Ill 7
dyspnea 7
dystonia 7
nausea and vomiting 7
masculinization 7
polydipsia 6
cough 6
myalgia 6
Scratch 6
apathy 6
bitter taste 5
spasm 5
sleepiness 5
discomfort 5
incoordination 5
insomnia 5
dry eye 5
bone pain 5
Fluctuation 4
chest pain 4
cancer pain 4
twitching 4
Catch 4
flushing 4
discomfort 4
hypocapnia 3
neurological disability 3
myoclonus 3
muscle stiffness 3
pelvic pain 3
agitation 3
syncope 3
tachypnea 3
sore throat 3
POA 3
more...
Drug
Forskolin 638
lysine 609
MAP 465
caffeine 297
ROS 278
IFN-gamma 239
Cardiovasc 235
IL-2 223
Gel 194
Dermatol 185
PTH 173
Glucagon 172
ICI 168
Asn 145
Nephron 119
K-252a 109
Angiotensin II 107
Ethanol 106
CSF 105
Histamine 101
NADH 80
DM1 70
EE2 70
IFN-beta 69
CaCl2 65
CaCl2 64
CaCl2 64
Sorafenib 62
Imatinib 61
ascorbate 59
Parkin 56
Rolipram 56
Parkin 56
Retinoic acid 55
DNase I 54
p75 51
Nitric Oxide 49
vitamin E 46
Gleevec 45
Indomethacin 44
Leaf 43
nitroglycerin 43
Alanine 42
Taxol 42
Sodium nitroprusside 40
CAM 40
Flavopiridol 39
CTX 39
Heme 38
Monit 37
Activin 35
Estrogens 33
ETA 32
Cilostazol 32
Fructose 31
ABC 30
Adriamycin 29
Ouabain 29
TAT 28
Gefitinib 28
PCP 27
Arsenic trioxide 27
ETS 27
-deoxyadenosine 26
Propofol 26
ADR 26
IL-11 24
Liraglutide 24
BH4 23
Growth hormone 23
Secretin 23
Growth hormone 23
Emodin 22
Bortezomib 22
TAK 22
Emodin 22
Glycerol 22
GRF 22
lactose 21
GHRP 21
more...
Enzyme
protein kinase 81284
protein kinase C 9214
mitogen-activated protein kinase 8941
AMPK 6885
ERK 3041
MEK 2472
calcineurin 2414
adenylate cyclase 2106
PKG 2085
GSK 1908
phosphodiesterase 1759
cdc2 1494
ATPase 1287
AMP-activated protein kinase 1285
phosphatidylinositol 3-kinase 1283
CaMKII 1236
focal adhesion kinase 1235
phospholipase C 1182
caspase-3 1071
guanylate cyclase 911
luciferase 894
proteasome 855
AMPK 697
phosphoinositide 3-kinase 644
alkaline phosphatase 613
RNA polymerase 570
NO synthase 498
protein phosphatase 2A 472
superoxide dismutase 453
myosin light chain kinase 448
trypsin 446
glutathione S-transferase 437
phosphorylase 399
MAP 388
tyrosine hydroxylase 384
thrombin 372
catalase 344
NADPH oxidase 322
PARP 314
PDE 313
phosphorylase kinase 305
NADPH oxidase 303
MEKK1 300
phospholipase A2 298
CPT 280
IKK 269
PDK1 258
acetyl-CoA carboxylase 257
hormone-sensitive lipase 254
CPT 247
lactate dehydrogenase 247
CPT 246
caspase-9 211
lipase 208
reverse transcriptase 204
polo-like kinase 1 202
APC 198
NOS 194
phosphoenolpyruvate carboxykinase 192
phosphoenolpyruvate carboxykinase 185
peroxidase 183
phosphoenolpyruvate carboxykinase 176
ACS 171
collagenase 166
RNase 166
caspase-8 164
RNase 160
topoisomerase 155
phospholipase D 155
pyruvate kinase 147
TOR 146
tyrosinase 144
chloramphenicol acetyltransferase 141
DNA polymerase 141
topoisomerase 140
renin 129
ornithine decarboxylase 127
GRK5 124
glutathione peroxidase 123
alanine aminotransferase 122
more...
Compound
cAMP 13554
calcium 9629
DNA 6868
Dec 5957
ATP 5560
serine 5397
AMP 5147
threonine 4272
tyrosine 4030
glucose 3625
phosphate 3047
cGMP 3023
acetate 2620
sodium 2519
oxygen 2456
nitric oxide 2019
alanine 1679
MEK 1480
arginine 1444
GTP 1328
water 1214
Clin 1178
glutamate 1163
lysine 972
sulfate 817
potassium 815
salt 795
Mg2+ 784
adenylate 773
leucine 757
ADP 710
cysteine 698
SDS 697
TNF 696
hydrogen 683
ADP 661
ADP 659
Forskolin 639
Insulin 636
His 625
Asp 611
DEAE 583
PMA 572
glycerol 550
PMA 544
NH2 544
Phe 520
ethanol 503
methionine 483
proline 477
COS 457
GMP 455
NMDA 444
MTT 434
phosphoserine 426
PGE 419
nitrogen 411
Gly 408
Cardiol 407
retinoic acid 395
MAP 390
PGE2 378
bromide 376
5-HT 376
manganese 373
GABA 367
GABA 362
zinc 361
AMPA 345
ACTH 334
urea 326
Casein 321
GDP 316
noradrenaline 315
H2O2 314
MDA 308
caffeine 299
galactose 277
TPA 274
TPA 274
more...