Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:2.7.11.1 (
protein kinase
)
81,284
document(s) hit in 31,850,051 MEDLINE articles (0.05 seconds)
.
Concepts found in the documents ranked by [
Frequency
|
Pointwise Mutual Information
|
Symmetric Conditional Probability
] .
Human Gene/Protein
Mol
9771
PKA
7170
cAMP-dependent protein kinase
6110
Sep
5579
ATP
5558
cyclin-dependent kinase
5526
AMP
4657
calmodulin
4655
insulin
3614
PKC
2823
threonine
2769
p38
2649
phosphatase
2575
cyclin
2417
MAPK
2416
ERK1
2317
Raf-1
2269
ERK
2153
PKG
2086
adenylate cyclase
1999
p21
1826
GSK
1802
p53
1789
serine/threonine protein kinase
1789
phosphodiesterase
1750
adenylyl cyclase
1703
MEK
1702
tyrosine kinase
1672
mTOR
1578
cytokine
1537
endoplasmic reticulum
1527
caspase-3
1371
protein phosphatase
1363
AKT
1331
GTP
1324
CK2
1323
mitogen-activated protein
1321
extracellular signal-regulated kinase
1307
phosphatidylinositol 3-kinase
1279
casein kinase
1261
histone
1230
c-Jun
1212
CREB
1208
polypeptide
1197
phosphorylating
1191
ATPase
1185
p27
1173
MAP kinase
1156
protein kinase B
1148
Rho
1122
phosphoprotein
1119
PI3K
1086
cyclin D1
1062
interferon
1037
casein
1031
catenin
1028
PKR
1005
JNK
990
Bcl-2
938
tumor necrosis factor
934
epidermal growth factor
867
proteasome
843
ubiquitin
829
lipopolysaccharide
802
nitric oxide synthase
793
serine/threonine kinase
757
CaMKII
733
protein kinase inhibitor
719
collagen
704
glucagon
702
TNF
696
AMPK
690
ADP
659
SDS
653
AMP-activated protein kinase
651
calcineurin
650
phosphoinositide 3-kinase
644
CDK2
615
MEK1
614
alkaline phosphatase
610
more...
Disease
cancer
6994
tumor
5111
Alzheimer's disease
1533
diabetes
1509
breast cancer
1289
tumorigenesis
1098
ischemia
924
pertussis
867
hepatocellular carcinoma
839
obesity
834
retinoblastoma
825
carcinoma
823
leukemia
802
depression
775
tumor growth
765
heart failure
673
SDS
653
carcinogenesis
645
melanoma
628
type 2 diabetes
619
hypertension
602
neuroblastoma
584
prostate cancer
523
ATM
512
tumor progression
507
Parkinson's disease
507
MCF
503
cholera
498
atherosclerosis
453
virus infection
443
lung cancer
428
lymphoma
421
glioma
407
hyperglycemia
397
HIV
383
colon cancer
382
adenocarcinoma
365
colorectal cancer
363
stroke
360
cold
343
herpes simplex
336
squamous cell carcinoma
279
pheochromocytoma
277
cystic fibrosis
273
immunodeficiency
268
asthma
264
cognitive impairment
263
NAME
260
Blocking
255
metastases
250
osteosarcoma
230
cardiovascular disease
227
cytomegalovirus
224
gastric cancer
223
ovarian cancer
217
cerebral ischemia
215
glioblastoma
215
myocardial infarction
212
dementia
209
fatty liver
203
schizophrenia
202
sarcoma
200
B-cell lymphoma
198
GSH
195
vaccinia
193
Rous sarcoma
192
infectious diseases
186
hepatitis C
182
chronic myeloid leukemia
181
myocardial ischemia
179
non-small cell lung cancer
178
acute myeloid leukemia
176
multiple myeloma
176
pancreatic cancer
175
bipolar disorder
174
malaria
170
PDE
170
sepsis
170
sepsis
166
APC
165
more...
Symptom
pain
609
starvation
546
seizures
147
collapse
118
diarrhea
93
functional recovery
72
anesthesia
70
ataxia
63
fatigue
60
analgesia
53
rundown
48
memory loss
42
weakness
41
exhaustion
35
hypothermia
35
respiratory distress
27
hyperoxia
25
acute stress
25
cachexia
24
overweight
24
acidity
22
stigma
21
Neuropathic pain
20
anorexia
20
cerebellar ataxia
19
vomiting
18
acute pain
17
tremor
17
hypercapnia
16
splenomegaly
15
polyuria
15
skin damage
15
headache
12
nausea
11
angina
11
thinning
11
erythema
11
Anoxia
10
constipation
10
hypotonia
10
HSA
9
hepatomegaly
9
despair
8
hunger
8
bradykinesia
7
Ill
7
dyspnea
7
dystonia
7
nausea and vomiting
7
masculinization
7
polydipsia
6
cough
6
myalgia
6
Scratch
6
apathy
6
bitter taste
5
spasm
5
sleepiness
5
discomfort
5
incoordination
5
insomnia
5
dry eye
5
bone pain
5
Fluctuation
4
chest pain
4
cancer pain
4
twitching
4
Catch
4
flushing
4
discomfort
4
hypocapnia
3
neurological disability
3
myoclonus
3
muscle stiffness
3
pelvic pain
3
agitation
3
syncope
3
tachypnea
3
sore throat
3
POA
3
more...
Drug
Forskolin
638
lysine
609
MAP
465
caffeine
297
ROS
278
IFN-gamma
239
Cardiovasc
235
IL-2
223
Gel
194
Dermatol
185
PTH
173
Glucagon
172
ICI
168
Asn
145
Nephron
119
K-252a
109
Angiotensin II
107
Ethanol
106
CSF
105
Histamine
101
NADH
80
DM1
70
EE2
70
IFN-beta
69
CaCl2
65
CaCl2
64
CaCl2
64
Sorafenib
62
Imatinib
61
ascorbate
59
Parkin
56
Rolipram
56
Parkin
56
Retinoic acid
55
DNase I
54
p75
51
Nitric Oxide
49
vitamin E
46
Gleevec
45
Indomethacin
44
Leaf
43
nitroglycerin
43
Alanine
42
Taxol
42
Sodium nitroprusside
40
CAM
40
Flavopiridol
39
CTX
39
Heme
38
Monit
37
Activin
35
Estrogens
33
ETA
32
Cilostazol
32
Fructose
31
ABC
30
Adriamycin
29
Ouabain
29
TAT
28
Gefitinib
28
PCP
27
Arsenic trioxide
27
ETS
27
-deoxyadenosine
26
Propofol
26
ADR
26
IL-11
24
Liraglutide
24
BH4
23
Growth hormone
23
Secretin
23
Growth hormone
23
Emodin
22
Bortezomib
22
TAK
22
Emodin
22
Glycerol
22
GRF
22
lactose
21
GHRP
21
more...
Enzyme
protein kinase
81284
protein kinase C
9214
mitogen-activated protein kinase
8941
AMPK
6885
ERK
3041
MEK
2472
calcineurin
2414
adenylate cyclase
2106
PKG
2085
GSK
1908
phosphodiesterase
1759
cdc2
1494
ATPase
1287
AMP-activated protein kinase
1285
phosphatidylinositol 3-kinase
1283
CaMKII
1236
focal adhesion kinase
1235
phospholipase C
1182
caspase-3
1071
guanylate cyclase
911
luciferase
894
proteasome
855
AMPK
697
phosphoinositide 3-kinase
644
alkaline phosphatase
613
RNA polymerase
570
NO synthase
498
protein phosphatase 2A
472
superoxide dismutase
453
myosin light chain kinase
448
trypsin
446
glutathione S-transferase
437
phosphorylase
399
MAP
388
tyrosine hydroxylase
384
thrombin
372
catalase
344
NADPH oxidase
322
PARP
314
PDE
313
phosphorylase kinase
305
NADPH oxidase
303
MEKK1
300
phospholipase A2
298
CPT
280
IKK
269
PDK1
258
acetyl-CoA carboxylase
257
hormone-sensitive lipase
254
CPT
247
lactate dehydrogenase
247
CPT
246
caspase-9
211
lipase
208
reverse transcriptase
204
polo-like kinase 1
202
APC
198
NOS
194
phosphoenolpyruvate carboxykinase
192
phosphoenolpyruvate carboxykinase
185
peroxidase
183
phosphoenolpyruvate carboxykinase
176
ACS
171
collagenase
166
RNase
166
caspase-8
164
RNase
160
topoisomerase
155
phospholipase D
155
pyruvate kinase
147
TOR
146
tyrosinase
144
chloramphenicol acetyltransferase
141
DNA polymerase
141
topoisomerase
140
renin
129
ornithine decarboxylase
127
GRK5
124
glutathione peroxidase
123
alanine aminotransferase
122
more...
Compound
cAMP
13554
calcium
9629
DNA
6868
Dec
5957
ATP
5560
serine
5397
AMP
5147
threonine
4272
tyrosine
4030
glucose
3625
phosphate
3047
cGMP
3023
acetate
2620
sodium
2519
oxygen
2456
nitric oxide
2019
alanine
1679
MEK
1480
arginine
1444
GTP
1328
water
1214
Clin
1178
glutamate
1163
lysine
972
sulfate
817
potassium
815
salt
795
Mg2+
784
adenylate
773
leucine
757
ADP
710
cysteine
698
SDS
697
TNF
696
hydrogen
683
ADP
661
ADP
659
Forskolin
639
Insulin
636
His
625
Asp
611
DEAE
583
PMA
572
glycerol
550
PMA
544
NH2
544
Phe
520
ethanol
503
methionine
483
proline
477
COS
457
GMP
455
NMDA
444
MTT
434
phosphoserine
426
PGE
419
nitrogen
411
Gly
408
Cardiol
407
retinoic acid
395
MAP
390
PGE2
378
bromide
376
5-HT
376
manganese
373
GABA
367
GABA
362
zinc
361
AMPA
345
ACTH
334
urea
326
Casein
321
GDP
316
noradrenaline
315
H2O2
314
MDA
308
caffeine
299
galactose
277
TPA
274
TPA
274
more...