Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:2.7.11.1 (
protein kinase
)
81,284
document(s) hit in 31,850,051 MEDLINE articles (0.06 seconds)
.
Concepts found in the documents ranked by [
Frequency
|
Pointwise Mutual Information
|
Symmetric Conditional Probability
] .
Human Gene/Protein
Mol
9771
PKA
7170
cAMP-dependent protein kinase
6110
Sep
5579
ATP
5558
cyclin-dependent kinase
5526
AMP
4657
calmodulin
4655
insulin
3614
PKC
2823
threonine
2769
p38
2649
phosphatase
2575
cyclin
2417
MAPK
2416
ERK1
2317
Raf-1
2269
ERK
2153
PKG
2086
adenylate cyclase
1999
p21
1826
GSK
1802
serine/threonine protein kinase
1789
p53
1789
phosphodiesterase
1750
adenylyl cyclase
1703
MEK
1702
tyrosine kinase
1672
mTOR
1578
cytokine
1537
endoplasmic reticulum
1527
caspase-3
1371
protein phosphatase
1363
AKT
1331
GTP
1324
CK2
1323
mitogen-activated protein
1321
extracellular signal-regulated kinase
1307
phosphatidylinositol 3-kinase
1279
casein kinase
1261
histone
1230
c-Jun
1212
CREB
1208
polypeptide
1197
phosphorylating
1191
ATPase
1185
p27
1173
MAP kinase
1156
protein kinase B
1148
Rho
1122
phosphoprotein
1119
PI3K
1086
cyclin D1
1062
interferon
1037
casein
1031
catenin
1028
PKR
1005
JNK
990
Bcl-2
938
tumor necrosis factor
934
epidermal growth factor
867
proteasome
843
ubiquitin
829
lipopolysaccharide
802
nitric oxide synthase
793
serine/threonine kinase
757
CaMKII
733
protein kinase inhibitor
719
collagen
704
glucagon
702
TNF
696
AMPK
690
ADP
659
SDS
653
AMP-activated protein kinase
651
calcineurin
650
phosphoinositide 3-kinase
644
CDK2
615
MEK1
614
alkaline phosphatase
610
cyclin E
608
epidermal growth factor receptor
597
CA1
590
guanylate cyclase
582
membrane-bound
561
GTPase
558
AP-1
553
IL-6
550
p38 mitogen-activated protein kinase
547
myosin
540
Protein kinase
532
ERK2
524
CDK4
517
insulin receptor
514
PKB
509
c-fos
507
angiotensin II
507
RhoA
500
cyclin A
494
beta-catenin
482
PKI
477
fused
470
Gen
464
estrogen receptor
458
p65
456
vascular endothelial growth factor
455
brain-derived neurotrophic factor
453
p16
451
glycogen synthase
438
BRAF
436
14-3-3
430
NMDA receptor
430
phospholamban
429
axonal
415
cAMP response element-binding protein
409
superoxide dismutase
409
protein kinase C inhibitor
408
p42
405
tyrosine hydroxylase
403
IFN
402
glycoprotein
401
ras
400
inducible nitric oxide synthase
393
protein tyrosine kinase
392
MAP
386
LPS
382
cyclooxygenase-2
382
nerve growth factor
377
thrombin
376
cAMP-response element
372
proliferating cell nuclear antigen
371
membrane protein
371
G protein-coupled receptor
362
GABA
360
p44
359
amyloid precursor protein
357
fibronectin
356
cytochrome c
356
vasopressin
352
myosin light chain kinase
349
interacting protein
349
platelet-derived growth factor
345
EGF
344
histone H1
340
cystic fibrosis transmembrane conductance regulator
337
RNA polymerase II
337
inhibitor 2
336
ACTH
328
serine kinase
328
guanylyl cyclase
327
TNF-alpha
324
extracellular signal-regulated kinase 1
323
IRS-1
323
proto-oncogene
319
PLC
319
tau protein
318
GDP
313
spermatozoa
311
interleukin-6
311
NMR
311
more...
Disease
cancer
6994
tumor
5111
Alzheimer's disease
1533
diabetes
1509
breast cancer
1289
tumorigenesis
1098
ischemia
924
pertussis
867
hepatocellular carcinoma
839
obesity
834
retinoblastoma
825
carcinoma
823
leukemia
802
depression
775
tumor growth
765
heart failure
673
SDS
653
carcinogenesis
645
melanoma
628
type 2 diabetes
619
hypertension
602
neuroblastoma
584
prostate cancer
523
ATM
512
tumor progression
507
Parkinson's disease
507
MCF
503
cholera
498
atherosclerosis
453
virus infection
443
lung cancer
428
lymphoma
421
glioma
407
hyperglycemia
397
HIV
383
colon cancer
382
adenocarcinoma
365
colorectal cancer
363
stroke
360
cold
343
herpes simplex
336
squamous cell carcinoma
279
pheochromocytoma
277
cystic fibrosis
273
immunodeficiency
268
asthma
264
cognitive impairment
263
NAME
260
Blocking
255
metastases
250
osteosarcoma
230
cardiovascular disease
227
cytomegalovirus
224
gastric cancer
223
ovarian cancer
217
glioblastoma
215
cerebral ischemia
215
myocardial infarction
212
dementia
209
fatty liver
203
schizophrenia
202
sarcoma
200
B-cell lymphoma
198
GSH
195
vaccinia
193
Rous sarcoma
192
infectious diseases
186
hepatitis C
182
chronic myeloid leukemia
181
myocardial ischemia
179
non-small cell lung cancer
178
multiple myeloma
176
acute myeloid leukemia
176
pancreatic cancer
175
bipolar disorder
174
malaria
170
sepsis
170
PDE
170
sepsis
166
APC
165
plaque
162
Epstein
159
DM1
153
rheumatoid arthritis
152
osteoporosis
146
epilepsy
142
memory impairment
142
metabolic syndrome
140
Infection
139
diabetic nephropathy
136
influenza
133
renal disease
131
liver cancer
129
lung carcinoma
128
Mycobacterium
128
mole
127
uterus
124
addiction
124
acute promyelocytic leukemia
124
amyotrophic lateral sclerosis
120
stomatitis
120
hyperinsulinemia
117
tuberous sclerosis
115
cardiomyopathy
113
tuberculosis
112
mole
112
renal cell carcinoma
111
heart disease
108
polycystic kidney
107
cervical cancer
106
glucose intolerance
103
Huntington's disease
103
osteoarthritis
102
hepatitis B
101
liver cancer
101
chronic obstructive pulmonary disease
100
neoplastic transformation
100
chronic lymphocytic leukemia
100
hyperlipidemia
99
Leukemia
98
arthritis
96
chronic pain
94
multiple sclerosis
94
pulmonary hypertension
89
papillary thyroid cancer
89
worms
83
astrocytoma
82
brain tumor
82
SCH
81
epithelial ovarian cancer
81
dilated cardiomyopathy
80
insulinoma
80
mammary tumor
80
acute lymphoblastic leukemia
79
Pituitary
77
chronic lymphocytic leukemia
77
infertility
76
bladder cancer
76
thymoma
75
chronic renal failure
75
systemic lupus erythematosus
74
Down syndrome
74
aggressiveness
74
autoimmune disease
74
skin cancer
73
ARF
72
liver disease
72
congestive heart failure
72
AIDS
72
Cushing's syndrome
72
ABL
71
glioblastoma multiforme
71
mental retardation
70
mental retardation
70
dehydration
70
thyroid cancer
69
SCID
69
proteinuria
68
coronary artery disease
68
dyslipidemia
68
more...
Symptom
pain
609
starvation
546
seizures
147
collapse
118
diarrhea
93
functional recovery
72
anesthesia
70
ataxia
63
fatigue
60
analgesia
53
rundown
48
memory loss
42
weakness
41
hypothermia
35
exhaustion
35
respiratory distress
27
hyperoxia
25
acute stress
25
overweight
24
cachexia
24
acidity
22
stigma
21
Neuropathic pain
20
anorexia
20
cerebellar ataxia
19
vomiting
18
acute pain
17
tremor
17
hypercapnia
16
skin damage
15
polyuria
15
splenomegaly
15
headache
12
nausea
11
angina
11
erythema
11
thinning
11
hypotonia
10
constipation
10
Anoxia
10
HSA
9
hepatomegaly
9
hunger
8
despair
8
dystonia
7
nausea and vomiting
7
dyspnea
7
bradykinesia
7
Ill
7
masculinization
7
apathy
6
myalgia
6
cough
6
polydipsia
6
Scratch
6
spasm
5
discomfort
5
bone pain
5
sleepiness
5
incoordination
5
insomnia
5
dry eye
5
bitter taste
5
discomfort
4
cancer pain
4
Catch
4
twitching
4
chest pain
4
Fluctuation
4
flushing
4
hypocapnia
3
neurological disability
3
decreased appetite
3
lethargy
3
syncope
3
chorea
3
muscle stiffness
3
tachypnea
3
pelvic pain
3
ACHE
3
sore throat
3
agitation
3
POA
3
Inflammatory pain
3
Spots
3
myoclonus
3
Crushing
2
spasticity
2
hepatosplenomegaly
2
orofacial pain
2
Sedation
2
forgetfulness
2
hemiplegia
2
dry skin
2
low back pain
2
photophobia
2
Lower urinary tract symptoms
2
stomach pain
2
anosmia
2
Decreased activity
2
neurological pain
2
dizziness
2
arthralgia
2
distraction
2
dysarthria
2
impaired motor coordination
2
menopausal symptoms
2
fasciculation
2
abnormal gait
2
abdominal pain
2
disturbed balance
2
vertigo
2
neuralgia
2
sneezing
2
Mucosal hyperplasia
1
Noise-induced hearing loss
1
blemishes
1
prostration
1
hemoptysis
1
autodigestion
1
Incisional pain
1
eds
1
chronic constipation
1
Pain symptoms
1
hangover
1
pallor
1
ENT
1
microbial colonization
1
Diaphragmatic weakness
1
urinary frequency
1
numbness
1
Excitable
1
Organ failure
1
tonic-clonic seizure
1
CSR
1
No adverse effect
1
ophthalmoplegia
1
Depressive symptoms
1
tense
1
loss of balance
1
muscle rigidity
1
Excitability
1
Quadriceps weakness
1
tinnitus
1
infant diarrhea
1
dental pain
1
trigeminy
1
skin irritant
1
DNA marker
1
rhinorrhea
1
motor symptom
1
hypersomnia
1
Stiffness
1
hopelessness
1
female puberty
1
astasia
1
right upper quadrant pain
1
Involuntary Movement
1
prostatism
1
back pain
1
more...
Drug
Forskolin
638
lysine
609
MAP
465
caffeine
297
ROS
278
IFN-gamma
239
Cardiovasc
235
IL-2
223
Gel
194
Dermatol
185
PTH
173
Glucagon
172
ICI
168
Asn
145
Nephron
119
K-252a
109
Angiotensin II
107
Ethanol
106
CSF
105
Histamine
101
NADH
80
EE2
70
DM1
70
IFN-beta
69
CaCl2
65
CaCl2
64
CaCl2
64
Sorafenib
62
Imatinib
61
ascorbate
59
Parkin
56
Parkin
56
Rolipram
56
Retinoic acid
55
DNase I
54
p75
51
Nitric Oxide
49
vitamin E
46
Gleevec
45
Indomethacin
44
Leaf
43
nitroglycerin
43
Taxol
42
Alanine
42
Sodium nitroprusside
40
CAM
40
CTX
39
Flavopiridol
39
Heme
38
Monit
37
Activin
35
Estrogens
33
ETA
32
Cilostazol
32
Fructose
31
ABC
30
Ouabain
29
Adriamycin
29
TAT
28
Gefitinib
28
PCP
27
Arsenic trioxide
27
ETS
27
Propofol
26
-deoxyadenosine
26
ADR
26
Liraglutide
24
IL-11
24
Secretin
23
BH4
23
Growth hormone
23
Growth hormone
23
GRF
22
Emodin
22
Emodin
22
Glycerol
22
Bortezomib
22
TAK
22
lactose
21
Portal
21
Phosphatidylserine
21
GHRP
21
MRC
20
Kenyan
20
Lovastatin
20
GEO
20
Theophylline
20
Glutathione
19
Mutagen
19
Amiloride
19
Iloprost
18
Trifluoperazine
18
Herceptin
18
Amiloride
17
G418
17
Luteinizing
17
Simvastatin
17
ZnCl2
16
citric acid
16
Fragment
16
ZnCl2
16
Biopolymers
16
NH3
15
CTX
15
CTX
15
L-tyrosine
15
TiO2
15
Ginseng
15
DFP
15
EPA
15
NVP
14
Erlotinib
14
Itraconazole
14
ROC
14
Asthma
14
CoCl2
14
CoCl2
14
Methylene blue
14
ADM
14
uPA
13
Docetaxel
13
Nephron
13
Adenosine triphosphate
13
Troglitazone
13
AC2
13
Atropine
12
Rosiglitazone
12
Glycyrrhiza
12
G-CSF
12
RFP
12
Fraction
12
Vitamin A
12
Radicicol
12
Exenatide
11
Papaverine
11
Epigallocatechin
11
Butaprost
11
CCL
11
Vitamin E
11
balanced salt solution
11
Dasatinib
11
DMAP
11
DEX
11
Everolimus
11
CIA
11
CDP
10
Etoposide
10
Photofrin
10
Ringer's solution
9
DHT
9
Salbutamol
9
Roflumilast
9
TTC
9
DDAVP
9
niacin
9
ACT
9
HCH
9
Lenalidomide
9
Imiquimod
9
Roflumilast
9
more...
Enzyme
protein kinase
81284
protein kinase C
9214
mitogen-activated protein kinase
8941
AMPK
6885
ERK
3041
MEK
2472
calcineurin
2414
adenylate cyclase
2106
PKG
2085
GSK
1908
phosphodiesterase
1759
cdc2
1494
ATPase
1287
AMP-activated protein kinase
1285
phosphatidylinositol 3-kinase
1283
CaMKII
1236
focal adhesion kinase
1235
phospholipase C
1182
caspase-3
1071
guanylate cyclase
911
luciferase
894
proteasome
855
AMPK
697
phosphoinositide 3-kinase
644
alkaline phosphatase
613
RNA polymerase
570
NO synthase
498
protein phosphatase 2A
472
superoxide dismutase
453
myosin light chain kinase
448
trypsin
446
glutathione S-transferase
437
phosphorylase
399
MAP
388
tyrosine hydroxylase
384
thrombin
372
catalase
344
NADPH oxidase
322
PARP
314
PDE
313
phosphorylase kinase
305
NADPH oxidase
303
MEKK1
300
phospholipase A2
298
CPT
280
IKK
269
PDK1
258
acetyl-CoA carboxylase
257
hormone-sensitive lipase
254
CPT
247
lactate dehydrogenase
247
CPT
246
caspase-9
211
lipase
208
reverse transcriptase
204
polo-like kinase 1
202
APC
198
NOS
194
phosphoenolpyruvate carboxykinase
192
phosphoenolpyruvate carboxykinase
185
peroxidase
183
phosphoenolpyruvate carboxykinase
176
ACS
171
collagenase
166
RNase
166
caspase-8
164
RNase
160
topoisomerase
155
phospholipase D
155
pyruvate kinase
147
TOR
146
tyrosinase
144
DNA polymerase
141
chloramphenicol acetyltransferase
141
topoisomerase
140
renin
129
ornithine decarboxylase
127
GRK5
124
glutathione peroxidase
123
alanine aminotransferase
122
acetylcholinesterase
114
complex I
114
beta-galactosidase
111
aspartate aminotransferase
108
creatine kinase
103
adenosine deaminase
103
adenosine deaminase
103
P-glycoprotein
98
chymotrypsin
96
glucose-6-phosphatase
94
heme oxygenase
93
acid phosphatase
91
thymidine kinase
91
urokinase-type plasminogen activator
91
GRK2
90
lipoprotein lipase
89
pyruvate dehydrogenase
89
lipoxygenase
86
endonuclease
83
phosphofructokinase
82
hexokinase
80
kinesin
79
phosphoenolpyruvate carboxylase
73
ribonucleotide reductase
73
glyceraldehyde-3-phosphate dehydrogenase
72
pyruvate dehydrogenase
71
ribonucleotide reductase
71
transcriptase
71
pyruvate dehydrogenase
71
cGMP phosphodiesterase
68
6-phosphofructo-2-kinase
63
caspase-1
63
histone acetyltransferase
62
glucokinase
61
glyceraldehyde-3-phosphate dehydrogenase
59
cholesterol esterase
59
ATP synthase
59
histidine kinase
56
glyceraldehyde-3-phosphate dehydrogenase
55
DCF
55
enolase
54
lysozyme
54
succinate dehydrogenase
53
glyceraldehyde-3-phosphate dehydrogenase
52
glyceraldehyde-3-phosphate dehydrogenase
52
triphosphatase
51
ribonuclease
51
trehalase
51
ribonuclease
51
aldehyde dehydrogenase
50
tryptophan hydroxylase
50
calcium pump
49
phosphatidylinositol 4-kinase
49
tissue plasminogen activator
48
choline acetyltransferase
47
CD10
46
PTPase
45
eEF2 kinase
45
AMP-activated kinase
45
NQO1
43
ACE
43
xanthine oxidase
42
CLK1
42
nitrate reductase
40
nitrate reductase
40
plasmin
40
nitrate reductase
40
nitrate reductase
40
nitrate reductase
40
nitrate reductase
40
rhodopsin kinase
38
diacylglycerol kinase
38
elastase
38
MMP
38
MPP
37
type 1 protein phosphatase
37
aldehyde dehydrogenase
37
HSD
37
DNase
37
glutamine synthetase
36
more...
Compound
cAMP
13554
calcium
9629
DNA
6868
Dec
5957
ATP
5560
serine
5397
AMP
5147
threonine
4272
tyrosine
4030
glucose
3625
phosphate
3047
cGMP
3023
acetate
2620
sodium
2519
oxygen
2456
nitric oxide
2019
alanine
1679
MEK
1480
arginine
1444
GTP
1328
water
1214
Clin
1178
glutamate
1163
lysine
972
sulfate
817
potassium
815
salt
795
Mg2+
784
adenylate
773
leucine
757
ADP
710
cysteine
698
SDS
697
TNF
696
hydrogen
683
ADP
661
ADP
659
Forskolin
639
Insulin
636
His
625
Asp
611
DEAE
583
PMA
572
glycerol
550
PMA
544
NH2
544
Phe
520
ethanol
503
methionine
483
proline
477
COS
457
GMP
455
NMDA
444
MTT
434
phosphoserine
426
PGE
419
nitrogen
411
Gly
408
Cardiol
407
retinoic acid
395
MAP
390
PGE2
378
bromide
376
5-HT
376
manganese
373
GABA
367
GABA
362
zinc
361
AMPA
345
ACTH
334
urea
326
Casein
321
GDP
316
noradrenaline
315
H2O2
314
MDA
308
caffeine
299
galactose
277
TPA
274
TPA
274
Serine
256
Triton X-100
252
CPT
248
Adenosine
247
CPT
246
Isoproterenol
230
ammonium
229
aspartic acid
228
Glycogen synthase
227
Ile
217
aldosterone
215
iodine
215
8-Br-cGMP
215
Dopamine
213
Phorbol
210
GSH
208
GSH
208
Ang II
207
Staurosporine
205
Staurosporine
205
prostacyclin
196
PEG
196
aspartic acid
194
2-methylpiperazine
193
tryptophan
191
pyrimidine
189
iron
189
NAD
189
isoquinoline
189
aspartic acid
188
Rapamycin
188
aspartic acid
188
prostaglandin E1
187
TSH
176
pyrimidine
175
glutamine
173
Glucagon
172
ACS
171
ACS
170
glutamic acid
169
ICI
168
Phosphatidylinositol
164
salicylic acid
161
Metformin
159
Metformin
159
CO2
158
N-acetylcysteine
158
dUTP
154
Neuronal
154
Lithium
150
NAD
144
THP
140
THP
140
NADPH
138
ATF
138
NADPH
138
tryptophan
136
CoA
136
PEG
135
tryptophan
133
Adrenal
133
tryptophan
133
cadmium
132
Angiotensin II
130
nicotinamide
130
AICAR
127
Tyrosine
126
Okadaic acid
125
ACh
124
Genistein
122
gamma-aminobutyric acid
122
UTP
121
EDTA
116
EDTA
116
Wortmannin
113
Estrogen
111
FK506
110
ADP-ribose
110
nitrate
108
vitamin D
107
more...