Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:2.7.11.1 (protein kinase)
81,284 document(s) hit in 31,850,051 MEDLINE articles (0.06 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
Mol 9771
PKA 7170
cAMP-dependent protein kinase 6110
Sep 5579
ATP 5558
cyclin-dependent kinase 5526
AMP 4657
calmodulin 4655
insulin 3614
PKC 2823
threonine 2769
p38 2649
phosphatase 2575
cyclin 2417
MAPK 2416
ERK1 2317
Raf-1 2269
ERK 2153
PKG 2086
adenylate cyclase 1999
p21 1826
GSK 1802
serine/threonine protein kinase 1789
p53 1789
phosphodiesterase 1750
adenylyl cyclase 1703
MEK 1702
tyrosine kinase 1672
mTOR 1578
cytokine 1537
endoplasmic reticulum 1527
caspase-3 1371
protein phosphatase 1363
AKT 1331
GTP 1324
CK2 1323
mitogen-activated protein 1321
extracellular signal-regulated kinase 1307
phosphatidylinositol 3-kinase 1279
casein kinase 1261
histone 1230
c-Jun 1212
CREB 1208
polypeptide 1197
phosphorylating 1191
ATPase 1185
p27 1173
MAP kinase 1156
protein kinase B 1148
Rho 1122
phosphoprotein 1119
PI3K 1086
cyclin D1 1062
interferon 1037
casein 1031
catenin 1028
PKR 1005
JNK 990
Bcl-2 938
tumor necrosis factor 934
epidermal growth factor 867
proteasome 843
ubiquitin 829
lipopolysaccharide 802
nitric oxide synthase 793
serine/threonine kinase 757
CaMKII 733
protein kinase inhibitor 719
collagen 704
glucagon 702
TNF 696
AMPK 690
ADP 659
SDS 653
AMP-activated protein kinase 651
calcineurin 650
phosphoinositide 3-kinase 644
CDK2 615
MEK1 614
alkaline phosphatase 610
cyclin E 608
epidermal growth factor receptor 597
CA1 590
guanylate cyclase 582
membrane-bound 561
GTPase 558
AP-1 553
IL-6 550
p38 mitogen-activated protein kinase 547
myosin 540
Protein kinase 532
ERK2 524
CDK4 517
insulin receptor 514
PKB 509
c-fos 507
angiotensin II 507
RhoA 500
cyclin A 494
beta-catenin 482
PKI 477
fused 470
Gen 464
estrogen receptor 458
p65 456
vascular endothelial growth factor 455
brain-derived neurotrophic factor 453
p16 451
glycogen synthase 438
BRAF 436
14-3-3 430
NMDA receptor 430
phospholamban 429
axonal 415
cAMP response element-binding protein 409
superoxide dismutase 409
protein kinase C inhibitor 408
p42 405
tyrosine hydroxylase 403
IFN 402
glycoprotein 401
ras 400
inducible nitric oxide synthase 393
protein tyrosine kinase 392
MAP 386
LPS 382
cyclooxygenase-2 382
nerve growth factor 377
thrombin 376
cAMP-response element 372
proliferating cell nuclear antigen 371
membrane protein 371
G protein-coupled receptor 362
GABA 360
p44 359
amyloid precursor protein 357
fibronectin 356
cytochrome c 356
vasopressin 352
myosin light chain kinase 349
interacting protein 349
platelet-derived growth factor 345
EGF 344
histone H1 340
cystic fibrosis transmembrane conductance regulator 337
RNA polymerase II 337
inhibitor 2 336
ACTH 328
serine kinase 328
guanylyl cyclase 327
TNF-alpha 324
extracellular signal-regulated kinase 1 323
IRS-1 323
proto-oncogene 319
PLC 319
tau protein 318
GDP 313
spermatozoa 311
interleukin-6 311
NMR 311
more...
Disease
cancer 6994
tumor 5111
Alzheimer's disease 1533
diabetes 1509
breast cancer 1289
tumorigenesis 1098
ischemia 924
pertussis 867
hepatocellular carcinoma 839
obesity 834
retinoblastoma 825
carcinoma 823
leukemia 802
depression 775
tumor growth 765
heart failure 673
SDS 653
carcinogenesis 645
melanoma 628
type 2 diabetes 619
hypertension 602
neuroblastoma 584
prostate cancer 523
ATM 512
tumor progression 507
Parkinson's disease 507
MCF 503
cholera 498
atherosclerosis 453
virus infection 443
lung cancer 428
lymphoma 421
glioma 407
hyperglycemia 397
HIV 383
colon cancer 382
adenocarcinoma 365
colorectal cancer 363
stroke 360
cold 343
herpes simplex 336
squamous cell carcinoma 279
pheochromocytoma 277
cystic fibrosis 273
immunodeficiency 268
asthma 264
cognitive impairment 263
NAME 260
Blocking 255
metastases 250
osteosarcoma 230
cardiovascular disease 227
cytomegalovirus 224
gastric cancer 223
ovarian cancer 217
glioblastoma 215
cerebral ischemia 215
myocardial infarction 212
dementia 209
fatty liver 203
schizophrenia 202
sarcoma 200
B-cell lymphoma 198
GSH 195
vaccinia 193
Rous sarcoma 192
infectious diseases 186
hepatitis C 182
chronic myeloid leukemia 181
myocardial ischemia 179
non-small cell lung cancer 178
multiple myeloma 176
acute myeloid leukemia 176
pancreatic cancer 175
bipolar disorder 174
malaria 170
sepsis 170
PDE 170
sepsis 166
APC 165
plaque 162
Epstein 159
DM1 153
rheumatoid arthritis 152
osteoporosis 146
epilepsy 142
memory impairment 142
metabolic syndrome 140
Infection 139
diabetic nephropathy 136
influenza 133
renal disease 131
liver cancer 129
lung carcinoma 128
Mycobacterium 128
mole 127
uterus 124
addiction 124
acute promyelocytic leukemia 124
amyotrophic lateral sclerosis 120
stomatitis 120
hyperinsulinemia 117
tuberous sclerosis 115
cardiomyopathy 113
tuberculosis 112
mole 112
renal cell carcinoma 111
heart disease 108
polycystic kidney 107
cervical cancer 106
glucose intolerance 103
Huntington's disease 103
osteoarthritis 102
hepatitis B 101
liver cancer 101
chronic obstructive pulmonary disease 100
neoplastic transformation 100
chronic lymphocytic leukemia 100
hyperlipidemia 99
Leukemia 98
arthritis 96
chronic pain 94
multiple sclerosis 94
pulmonary hypertension 89
papillary thyroid cancer 89
worms 83
astrocytoma 82
brain tumor 82
SCH 81
epithelial ovarian cancer 81
dilated cardiomyopathy 80
insulinoma 80
mammary tumor 80
acute lymphoblastic leukemia 79
Pituitary 77
chronic lymphocytic leukemia 77
infertility 76
bladder cancer 76
thymoma 75
chronic renal failure 75
systemic lupus erythematosus 74
Down syndrome 74
aggressiveness 74
autoimmune disease 74
skin cancer 73
ARF 72
liver disease 72
congestive heart failure 72
AIDS 72
Cushing's syndrome 72
ABL 71
glioblastoma multiforme 71
mental retardation 70
mental retardation 70
dehydration 70
thyroid cancer 69
SCID 69
proteinuria 68
coronary artery disease 68
dyslipidemia 68
more...
Symptom
pain 609
starvation 546
seizures 147
collapse 118
diarrhea 93
functional recovery 72
anesthesia 70
ataxia 63
fatigue 60
analgesia 53
rundown 48
memory loss 42
weakness 41
hypothermia 35
exhaustion 35
respiratory distress 27
hyperoxia 25
acute stress 25
overweight 24
cachexia 24
acidity 22
stigma 21
Neuropathic pain 20
anorexia 20
cerebellar ataxia 19
vomiting 18
acute pain 17
tremor 17
hypercapnia 16
skin damage 15
polyuria 15
splenomegaly 15
headache 12
nausea 11
angina 11
erythema 11
thinning 11
hypotonia 10
constipation 10
Anoxia 10
HSA 9
hepatomegaly 9
hunger 8
despair 8
dystonia 7
nausea and vomiting 7
dyspnea 7
bradykinesia 7
Ill 7
masculinization 7
apathy 6
myalgia 6
cough 6
polydipsia 6
Scratch 6
spasm 5
discomfort 5
bone pain 5
sleepiness 5
incoordination 5
insomnia 5
dry eye 5
bitter taste 5
discomfort 4
cancer pain 4
Catch 4
twitching 4
chest pain 4
Fluctuation 4
flushing 4
hypocapnia 3
neurological disability 3
decreased appetite 3
lethargy 3
syncope 3
chorea 3
muscle stiffness 3
tachypnea 3
pelvic pain 3
ACHE 3
sore throat 3
agitation 3
POA 3
Inflammatory pain 3
Spots 3
myoclonus 3
Crushing 2
spasticity 2
hepatosplenomegaly 2
orofacial pain 2
Sedation 2
forgetfulness 2
hemiplegia 2
dry skin 2
low back pain 2
photophobia 2
Lower urinary tract symptoms 2
stomach pain 2
anosmia 2
Decreased activity 2
neurological pain 2
dizziness 2
arthralgia 2
distraction 2
dysarthria 2
impaired motor coordination 2
menopausal symptoms 2
fasciculation 2
abnormal gait 2
abdominal pain 2
disturbed balance 2
vertigo 2
neuralgia 2
sneezing 2
Mucosal hyperplasia 1
Noise-induced hearing loss 1
blemishes 1
prostration 1
hemoptysis 1
autodigestion 1
Incisional pain 1
eds 1
chronic constipation 1
Pain symptoms 1
hangover 1
pallor 1
ENT 1
microbial colonization 1
Diaphragmatic weakness 1
urinary frequency 1
numbness 1
Excitable 1
Organ failure 1
tonic-clonic seizure 1
CSR 1
No adverse effect 1
ophthalmoplegia 1
Depressive symptoms 1
tense 1
loss of balance 1
muscle rigidity 1
Excitability 1
Quadriceps weakness 1
tinnitus 1
infant diarrhea 1
dental pain 1
trigeminy 1
skin irritant 1
DNA marker 1
rhinorrhea 1
motor symptom 1
hypersomnia 1
Stiffness 1
hopelessness 1
female puberty 1
astasia 1
right upper quadrant pain 1
Involuntary Movement 1
prostatism 1
back pain 1
more...
Drug
Forskolin 638
lysine 609
MAP 465
caffeine 297
ROS 278
IFN-gamma 239
Cardiovasc 235
IL-2 223
Gel 194
Dermatol 185
PTH 173
Glucagon 172
ICI 168
Asn 145
Nephron 119
K-252a 109
Angiotensin II 107
Ethanol 106
CSF 105
Histamine 101
NADH 80
EE2 70
DM1 70
IFN-beta 69
CaCl2 65
CaCl2 64
CaCl2 64
Sorafenib 62
Imatinib 61
ascorbate 59
Parkin 56
Parkin 56
Rolipram 56
Retinoic acid 55
DNase I 54
p75 51
Nitric Oxide 49
vitamin E 46
Gleevec 45
Indomethacin 44
Leaf 43
nitroglycerin 43
Taxol 42
Alanine 42
Sodium nitroprusside 40
CAM 40
CTX 39
Flavopiridol 39
Heme 38
Monit 37
Activin 35
Estrogens 33
ETA 32
Cilostazol 32
Fructose 31
ABC 30
Ouabain 29
Adriamycin 29
TAT 28
Gefitinib 28
PCP 27
Arsenic trioxide 27
ETS 27
Propofol 26
-deoxyadenosine 26
ADR 26
Liraglutide 24
IL-11 24
Secretin 23
BH4 23
Growth hormone 23
Growth hormone 23
GRF 22
Emodin 22
Emodin 22
Glycerol 22
Bortezomib 22
TAK 22
lactose 21
Portal 21
Phosphatidylserine 21
GHRP 21
MRC 20
Kenyan 20
Lovastatin 20
GEO 20
Theophylline 20
Glutathione 19
Mutagen 19
Amiloride 19
Iloprost 18
Trifluoperazine 18
Herceptin 18
Amiloride 17
G418 17
Luteinizing 17
Simvastatin 17
ZnCl2 16
citric acid 16
Fragment 16
ZnCl2 16
Biopolymers 16
NH3 15
CTX 15
CTX 15
L-tyrosine 15
TiO2 15
Ginseng 15
DFP 15
EPA 15
NVP 14
Erlotinib 14
Itraconazole 14
ROC 14
Asthma 14
CoCl2 14
CoCl2 14
Methylene blue 14
ADM 14
uPA 13
Docetaxel 13
Nephron 13
Adenosine triphosphate 13
Troglitazone 13
AC2 13
Atropine 12
Rosiglitazone 12
Glycyrrhiza 12
G-CSF 12
RFP 12
Fraction 12
Vitamin A 12
Radicicol 12
Exenatide 11
Papaverine 11
Epigallocatechin 11
Butaprost 11
CCL 11
Vitamin E 11
balanced salt solution 11
Dasatinib 11
DMAP 11
DEX 11
Everolimus 11
CIA 11
CDP 10
Etoposide 10
Photofrin 10
Ringer's solution 9
DHT 9
Salbutamol 9
Roflumilast 9
TTC 9
DDAVP 9
niacin 9
ACT 9
HCH 9
Lenalidomide 9
Imiquimod 9
Roflumilast 9
more...
Enzyme
protein kinase 81284
protein kinase C 9214
mitogen-activated protein kinase 8941
AMPK 6885
ERK 3041
MEK 2472
calcineurin 2414
adenylate cyclase 2106
PKG 2085
GSK 1908
phosphodiesterase 1759
cdc2 1494
ATPase 1287
AMP-activated protein kinase 1285
phosphatidylinositol 3-kinase 1283
CaMKII 1236
focal adhesion kinase 1235
phospholipase C 1182
caspase-3 1071
guanylate cyclase 911
luciferase 894
proteasome 855
AMPK 697
phosphoinositide 3-kinase 644
alkaline phosphatase 613
RNA polymerase 570
NO synthase 498
protein phosphatase 2A 472
superoxide dismutase 453
myosin light chain kinase 448
trypsin 446
glutathione S-transferase 437
phosphorylase 399
MAP 388
tyrosine hydroxylase 384
thrombin 372
catalase 344
NADPH oxidase 322
PARP 314
PDE 313
phosphorylase kinase 305
NADPH oxidase 303
MEKK1 300
phospholipase A2 298
CPT 280
IKK 269
PDK1 258
acetyl-CoA carboxylase 257
hormone-sensitive lipase 254
CPT 247
lactate dehydrogenase 247
CPT 246
caspase-9 211
lipase 208
reverse transcriptase 204
polo-like kinase 1 202
APC 198
NOS 194
phosphoenolpyruvate carboxykinase 192
phosphoenolpyruvate carboxykinase 185
peroxidase 183
phosphoenolpyruvate carboxykinase 176
ACS 171
collagenase 166
RNase 166
caspase-8 164
RNase 160
topoisomerase 155
phospholipase D 155
pyruvate kinase 147
TOR 146
tyrosinase 144
DNA polymerase 141
chloramphenicol acetyltransferase 141
topoisomerase 140
renin 129
ornithine decarboxylase 127
GRK5 124
glutathione peroxidase 123
alanine aminotransferase 122
acetylcholinesterase 114
complex I 114
beta-galactosidase 111
aspartate aminotransferase 108
creatine kinase 103
adenosine deaminase 103
adenosine deaminase 103
P-glycoprotein 98
chymotrypsin 96
glucose-6-phosphatase 94
heme oxygenase 93
acid phosphatase 91
thymidine kinase 91
urokinase-type plasminogen activator 91
GRK2 90
lipoprotein lipase 89
pyruvate dehydrogenase 89
lipoxygenase 86
endonuclease 83
phosphofructokinase 82
hexokinase 80
kinesin 79
phosphoenolpyruvate carboxylase 73
ribonucleotide reductase 73
glyceraldehyde-3-phosphate dehydrogenase 72
pyruvate dehydrogenase 71
ribonucleotide reductase 71
transcriptase 71
pyruvate dehydrogenase 71
cGMP phosphodiesterase 68
6-phosphofructo-2-kinase 63
caspase-1 63
histone acetyltransferase 62
glucokinase 61
glyceraldehyde-3-phosphate dehydrogenase 59
cholesterol esterase 59
ATP synthase 59
histidine kinase 56
glyceraldehyde-3-phosphate dehydrogenase 55
DCF 55
enolase 54
lysozyme 54
succinate dehydrogenase 53
glyceraldehyde-3-phosphate dehydrogenase 52
glyceraldehyde-3-phosphate dehydrogenase 52
triphosphatase 51
ribonuclease 51
trehalase 51
ribonuclease 51
aldehyde dehydrogenase 50
tryptophan hydroxylase 50
calcium pump 49
phosphatidylinositol 4-kinase 49
tissue plasminogen activator 48
choline acetyltransferase 47
CD10 46
PTPase 45
eEF2 kinase 45
AMP-activated kinase 45
NQO1 43
ACE 43
xanthine oxidase 42
CLK1 42
nitrate reductase 40
nitrate reductase 40
plasmin 40
nitrate reductase 40
nitrate reductase 40
nitrate reductase 40
nitrate reductase 40
rhodopsin kinase 38
diacylglycerol kinase 38
elastase 38
MMP 38
MPP 37
type 1 protein phosphatase 37
aldehyde dehydrogenase 37
HSD 37
DNase 37
glutamine synthetase 36
more...
Compound
cAMP 13554
calcium 9629
DNA 6868
Dec 5957
ATP 5560
serine 5397
AMP 5147
threonine 4272
tyrosine 4030
glucose 3625
phosphate 3047
cGMP 3023
acetate 2620
sodium 2519
oxygen 2456
nitric oxide 2019
alanine 1679
MEK 1480
arginine 1444
GTP 1328
water 1214
Clin 1178
glutamate 1163
lysine 972
sulfate 817
potassium 815
salt 795
Mg2+ 784
adenylate 773
leucine 757
ADP 710
cysteine 698
SDS 697
TNF 696
hydrogen 683
ADP 661
ADP 659
Forskolin 639
Insulin 636
His 625
Asp 611
DEAE 583
PMA 572
glycerol 550
PMA 544
NH2 544
Phe 520
ethanol 503
methionine 483
proline 477
COS 457
GMP 455
NMDA 444
MTT 434
phosphoserine 426
PGE 419
nitrogen 411
Gly 408
Cardiol 407
retinoic acid 395
MAP 390
PGE2 378
bromide 376
5-HT 376
manganese 373
GABA 367
GABA 362
zinc 361
AMPA 345
ACTH 334
urea 326
Casein 321
GDP 316
noradrenaline 315
H2O2 314
MDA 308
caffeine 299
galactose 277
TPA 274
TPA 274
Serine 256
Triton X-100 252
CPT 248
Adenosine 247
CPT 246
Isoproterenol 230
ammonium 229
aspartic acid 228
Glycogen synthase 227
Ile 217
aldosterone 215
iodine 215
8-Br-cGMP 215
Dopamine 213
Phorbol 210
GSH 208
GSH 208
Ang II 207
Staurosporine 205
Staurosporine 205
prostacyclin 196
PEG 196
aspartic acid 194
2-methylpiperazine 193
tryptophan 191
pyrimidine 189
iron 189
NAD 189
isoquinoline 189
aspartic acid 188
Rapamycin 188
aspartic acid 188
prostaglandin E1 187
TSH 176
pyrimidine 175
glutamine 173
Glucagon 172
ACS 171
ACS 170
glutamic acid 169
ICI 168
Phosphatidylinositol 164
salicylic acid 161
Metformin 159
Metformin 159
CO2 158
N-acetylcysteine 158
dUTP 154
Neuronal 154
Lithium 150
NAD 144
THP 140
THP 140
NADPH 138
ATF 138
NADPH 138
tryptophan 136
CoA 136
PEG 135
tryptophan 133
Adrenal 133
tryptophan 133
cadmium 132
Angiotensin II 130
nicotinamide 130
AICAR 127
Tyrosine 126
Okadaic acid 125
ACh 124
Genistein 122
gamma-aminobutyric acid 122
UTP 121
EDTA 116
EDTA 116
Wortmannin 113
Estrogen 111
FK506 110
ADP-ribose 110
nitrate 108
vitamin D 107
more...