Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:2.7.11.1 (
protein kinase
)
81,284
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
DSTYK
(Dual serine/threonine and tyrosine protein kinase) is a putative dual Ser/Thr and Tyr
protein kinase
with unique structural features. It is proposed that
DSTYK
may play important roles in brain because of its high expression in most brain areas. In the present study, a
DSTYK
knockout (KO) mouse line with the ablation of C-terminal of
DSTYK
including the kinase domain was generated to study the physiological function of
DSTYK
. The
DSTYK
KO mice are fertile and have no significant morphological defects revealed by Nissl staining compared with wildtype mice. Open field test and rotarod test showed there is no obvious difference in basic motor and balance capacity between the
DSTYK
homozygous KO mice and
DSTYK
heterozygous KO mice. In water maze test, however, the
DSTYK
homozygous KO mice show impaired capabilities of learning and memory compared with the
DSTYK
heterozygous KO mice.
...
PMID:DSTYK kinase domain ablation impaired the mice capabilities of learning and memory in water maze test. 2540 Jul 26
