Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:2.7.11.1 (
protein kinase
)
81,284
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
UDP-glucuronate decarboxylase
(
UGD
) catalyzes the formation of UDP-xylose from UDP-glucuronate. UDP-xylose is then used to initiate glycosaminoglycan biosynthesis on the core protein of proteoglycans. In a yeast two-hybrid screen with the
protein kinase
Akt (protein kinase B), we detected interactions with a novel sequence, which we cloned and expressed. The expressed protein displayed
UGD
activity but did not display the activities of homologous nucleotide sugar epimerases or dehydratases. We did not detect phosphorylation of
UGD
by Akt nor did we detect any influence of Akt on
UGD
activity. Effects of
UGD
on Akt kinase activity were also absent. Northern blot and Western blot analyses revealed the presence of
UGD
in multiple tissues and brain regions. Subcellular studies and histochemistry localized
UGD
protein to the perinuclear Golgi where xylosylation of proteoglycan core proteins is known to occur.
...
PMID:UDP-glucuronate decarboxylase, a key enzyme in proteoglycan synthesis: cloning, characterization, and localization. 1187 87
