Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:2.7.11.1 (
protein kinase
)
81,284
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Death-associated
protein kinase
(DAPK) is a multi-domain Ser/Thr protein kinase with an important role in apoptosis regulation. In these studies we have identified a DAPK-interacting protein called
DIP-1
, which is a novel multi-RING finger protein. The RING finger motifs of
DIP-1
have E3 ligase activity that can auto-ubiquitinate
DIP-1
in vitro. In vivo,
DIP-1
is detected as a polyubiquitinated protein, suggesting that the intracellular levels of
DIP-1
are regulated by the ubiquitin-proteasome system. Transient expression of
DIP-1
in HeLa cells antagonizes the anti-apoptotic function of DAPK to promote a caspase-dependent apoptosis. These studies also demonstrate that DAPK is an in vitro and in vivo target for ubiquitination by
DIP-1
, thereby providing a mechanism by which DAPK activities can be regulated through proteasomal degradation.
...
PMID:A death-associated protein kinase (DAPK)-interacting protein, DIP-1, is an E3 ubiquitin ligase that promotes tumor necrosis factor-induced apoptosis and regulates the cellular levels of DAPK. 1235 49
