Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:2.7.11.1 (protein kinase)
 81,284 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Slight alterations in calmodulin-stimulated and distinct alterations in cAMP-dependent regulation of calcium transport were found in dog heart microsomes under conditions of circulatory hypoxia as compared with myocardium of healthy animals. After addition into the incubation mixture of exogenous protein kinase simultaneously with calmodulin and cAMP the rate of 45Ca accumulation became similar both in microsomes of intact and impaired myocardium. In the hypoxia membrane-bound calmodulin was dissociated in cardiomyocytes and its content was increased in cytosol, whereas content of cAMP tended to decrease; under these conditions activity of Ca2+-ATPase in sarcoplasmic reticulum was similar to the control values.
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PMID:[Cyclic AMP level, dissociation of membrane-bound calmodulin and regulation of calcium transport in the heart sarcoplasmatic reticulum in circulatory hypoxia]. 299 24

10(-6) M cAMP were shown to induce a 61% and 21% increase in 45Ca binding to sarcolemma proteins in intact and injured (circulatory hypoxia) hearts, respectively. The addition of exogenous protein kinase equalized 45Ca-binding levels in normal and impaired sarcolemma. The decrease in 45Ca-binding capacity by 16 and 36% was detected in the presence of 10(-7) and 10(-6) M of cGMP, respectively. In impaired hearts, cAMP and Ca-ATPase activity levels remain constant, while cGMP content increases, as compared to normal myocardial level.
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PMID:[Cyclic GMP- and AMP-modified calcium binding by the myocardial sarcolemma in circulatory hypoxia]. 302 Dec 58

The phosphorylation of phospholamban from dog myocardium is shown to correlate with the protein sensitivity to tryptic attack both in undamaged myocardium and under conditions of circulatory hypoxia and experimental infarction. In the absence of "exogenous" protein kinase a decreased phosphorylation of phospholamban is observed in the incubation mixture containing 10(-6) M cAMP both for circulatory hypoxia and myocardial infarction. In the latter case the phosphorylation remains diminished in the presence of "exogenous" protein kinase as well. The sarcoplasmic reticulum from damaged myocardium exhibited changes in the velocity of the oxalate-dependent transport of calcium which correlated with the corresponding degree of the phospholamban phosphorylation.
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PMID:[Structural and functional modifications of phospholamban and regulation of calcium transport in the sarcoplasmic reticulum under conditions of metabolic cardiac insufficiency]. 400 64