Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:2.7.10.2 (focal adhesion kinase)
 44,029 document(s) hit in 31,850,051 MEDLINE articles (0.03 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
STD 7778
JAK2 5448
focal adhesion kinase 4790
ABL 4280
BCR 3722
tyrosine kinase 3403
Mol 2948
EMT 2868
FAK 2860
Sep 2804
PKB 2642
STAT3 2190
cytokine 1785
SRM 1688
JAK1 1669
SRC 1641
AKT 1584
PI3K 1430
STAT 1322
ERK 1178
paxillin 1092
Bruton's tyrosine kinase 1077
insulin 1077
Janus kinase 2 1070
MAPK 1038
ERK1 1007
protein kinase B 978
fibronectin 976
collagen 916
STAT5 906
JAK3 837
p53 805
mTOR 788
p38 758
IL-6 747
E-cadherin 732
STAT1 691
CD4 689
Janus kinase 686
phosphatidylinositol 3-kinase 647
ABL1 610
ARG 602
caspase-3 573
lymphoid 558
interferon 550
spleen tyrosine kinase 534
TEC 530
catenin 520
Bcl-2 502
Rho 500
TNF 496
FES 493
BTK 489
IFN 488
EGFR 482
MEK 479
ATP 474
JNK 470
receptor tyrosine kinase 433
RhoA 431
ZAP-70 430
phosphatase 428
extracellular signal-regulated kinase 427
signal transducer and activator of transcription 3 425
MPL 420
c-Src 419
vascular endothelial growth factor 400
PTEN 393
erythroid 385
epidermal growth factor receptor 381
BCR-ABL1 379
vinculin 373
vimentin 371
phosphoinositide 3-kinase 352
PKC 348
FPS 347
CML 345
TYK2 344
NMR 335
CD34 329
matrix metalloproteinase 326
tumor necrosis factor 317
protein tyrosine kinase 314
VEGF 310
interleukin-6 301
erythropoietin 298
p21 298
CSK 293
N-cadherin 289
Calreticulin 289
cyclin D1 285
KIT 283
lipopolysaccharide 279
leptin 276
MMP-9 274
BCR/ABL 274
SYN 271
IL-2 267
IRS-1 263
SRK 260
mitogen-activated protein 258
threonine 257
p56lck 250
TEL 250
ALL 249
CD8 249
FER 248
MMP-2 247
chemokine 247
IL-4 247
IL-10 245
LYN 245
MAP kinase 244
c-kit 244
FLT3 237
cytokine receptor 237
bcr 236
epidermal growth factor 235
ITK 234
LPS 231
Janus kinase 1 229
MET 229
BCR-ABL fusion 227
growth hormone 223
adaptor protein 223
GSK 223
c-Jun 222
hemoglobin 221
p65 220
FYN 219
LCK 216
insulin receptor 214
PP2 210
GTPase 206
proline-rich tyrosine kinase 2 206
proteasome 204
TCR 202
fused 201
PI3 201
CD44 199
EGF 196
glycoprotein 195
TLR4 194
PYK2 194
MYC 194
HER2 193
BRAF 193
serine/threonine kinase 192
proto-oncogene 191
IL-8 191
estrogen receptor 191
c-Myc 190
histone 186
pleckstrin 182
CXCR4 182
p210 181
talin 179
proline-rich 179
inducible nitric oxide synthase 176
ICP 176
more...
Disease
STD 7780
cancer 7623
AIDS 6379
tumor 5148
ABL 4280
HIV 3413
chronic myeloid leukemia 3051
EMT 2868
leukemia 2083
breast cancer 1457
myeloproliferative disorders 1008
tumor growth 962
tumorigenesis 895
tumor progression 849
polycythemia vera 834
acute lymphoblastic leukemia 805
essential thrombocythemia 758
lymphoma 722
carcinoma 691
acute myeloid leukemia 674
Leukemia 605
myelofibrosis 589
immunodeficiency 587
primary myelofibrosis 581
syphilis 580
hepatocellular carcinoma 570
TEC 530
metastases 528
lung cancer 508
melanoma 479
prostate cancer 463
diabetes 449
Chlamydia 447
chronic lymphocytic leukemia 447
carcinogenesis 417
adenocarcinoma 409
blast crisis 394
colorectal cancer 393
chronic lymphocytic leukemia 336
obesity 324
gastric cancer 319
thrombocytosis 317
squamous cell carcinoma 316
rheumatoid arthritis 313
MCF 308
glioma 306
anemia 298
non-small cell lung cancer 268
colon cancer 268
myelodysplastic syndrome 266
multiple myeloma 262
glioblastoma 260
pancreatic cancer 254
B-cell lymphoma 248
ovarian cancer 247
minimal residual disease 244
X-linked agammaglobulinemia 235
ischemia 229
atherosclerosis 225
SCID 223
hepatitis B 222
Alzheimer's disease 221
hypertension 214
gonococcal 214
infectious diseases 212
leukemogenesis 208
tuberculosis 204
Hodgkin's disease 197
neuroblastoma 193
herpes simplex 178
cold 177
type 2 diabetes 176
ICP 176
thrombocytopenia 175
arthritis 174
depression 173
genital warts 167
acute leukemia 163
cervical cancer 163
stroke 161
osteosarcoma 158
hematologic malignancies 155
hepatitis C 154
aggressiveness 147
liver cancer 144
primary tumor 142
sepsis 141
urethritis 140
Parkinson's disease 139
ATM 138
Adhesion 137
erythrocytosis 136
systemic lupus erythematosus 134
sepsis 134
autoimmune disease 130
Kaposi's sarcoma 129
mantle cell lymphoma 128
residual disease 126
Infection 126
renal cell carcinoma 125
B-ALL 122
Blocking 122
warts 120
asthma 120
bladder cancer 116
graft-versus-host disease 113
sarcoma 110
tumor angiogenesis 109
cardiovascular disease 109
virus infection 108
chronic phase CML 108
T-cell acute lymphoblastic leukemia 107
dysplasia 106
psoriasis 105
liver cancer 102
Mycoplasma 101
plaque 96
epithelial ovarian cancer 96
NOD 96
bacterial vaginosis 95
myocardial infarction 95
lung carcinoma 95
Epstein 95
heart failure 95
Mycobacterium 94
WT1 94
multiple sclerosis 91
glioblastoma multiforme 91
GSH 90
pneumonia 89
genital herpes 87
cataract 87
metastatic breast cancer 86
pertussis 85
APC 84
pelvic inflammatory disease 84
hyperglycemia 84
cytomegalovirus 83
inflammatory bowel disease 82
brain tumor 82
chronic myelomonocytic leukemia 81
neutropenia 81
renal disease 81
mammary tumor 80
Hepatocellular carcinoma 80
retinoblastoma 79
chronic myeloproliferative disorders 79
influenza 78
lymphoblastic leukemia 78
osteoporosis 77
PML 77
pruritus 76
infertility 76
West 76
hepatitis 75
colitis 74
trichomoniasis 73
eosinophilia 73
NAME 73
childhood ALL 70
more...
Symptom
splenomegaly 335
pain 204
diarrhea 124
fatigue 107
stigma 92
starvation 81
headache 52
collapse 47
abdominal pain 41
nausea 41
seizures 39
anesthesia 36
exhaustion 34
vomiting 33
functional recovery 32
respiratory distress 31
hepatosplenomegaly 30
discomfort 28
anorexia 28
urethral discharge 28
cough 26
discomfort 25
dysuria 25
dyspnea 24
overweight 23
weakness 21
acidity 18
pelvic pain 17
erythema 17
hypothermia 15
night sweats 15
tremor 14
hepatomegaly 14
dizziness 14
HSA 13
arthralgia 12
chest pain 12
nausea and vomiting 11
thinning 10
cachexia 10
agitation 9
hyperoxia 9
insomnia 9
Ill 9
hemiplegia 9
constipation 9
acute pain 8
dry eye 8
asthenia 8
bone pain 8
dystonia 7
abdominal discomfort 7
Scratch 7
shortness of breath 7
ataxia 7
spasticity 7
Neuropathic pain 7
lethargy 6
vertigo 6
low back pain 6
analgesia 6
angina 6
cerebellar ataxia 6
Fear of falling 6
Fear of falling 6
distraction 6
gumma 5
muscle cramps 5
back pain 5
epigastric pain 5
syncope 5
hypercapnia 4
hypotonia 4
myalgia 4
sore throat 4
shoulder pain 4
tinnitus 4
masculinization 3
chills 3
CSR 3
sleepiness 3
hypoproteinemia 3
apathy 3
Depressive symptoms 3
penile lesion 3
adenitis 3
incoordination 3
livedo 3
Spots 3
facial pain 3
fever of unknown origin 3
flushing 3
neck pain 3
paresthesia 3
dry skin 3
rales 3
cyanosis 3
exertional dyspnea 3
vestibulitis 3
memory loss 3
snoring 3
spasm 3
neurological disability 3
hemoptysis 3
blurred vision 3
testicular pain 3
hoarseness 2
vaginal itching 2
hunger 2
muscle stiffness 2
forgetfulness 2
bitter taste 2
Decreased activity 2
impaired motor coordination 2
meningism 2
alexithymia 2
skin damage 2
hypertonia 2
Stiffness 2
myoclonus 2
numbness 2
Wind 2
tenesmus 2
productive cough 2
physical appearance 2
rigors 2
pallor 2
chronic cough 2
Physical findings 2
skin irritation 2
loss of balance 2
Primary syphilis 2
excessive sweating 2
tachypnea 2
Genital discharge 2
nasal discharge 2
musculoskeletal disability 1
itchy nose 1
DNA marker 1
hip pain 1
partial seizure 1
Fluctuation 1
wheezing 1
drooling 1
skin pain 1
hypocapnia 1
false labor 1
Flu-like symptoms 1
hot flushes 1
urinary frequency 1
photophobia 1
tingling 1
chorea 1
Factitious fever 1
Asynergia 1
physical symptom 1
lassitude 1
right upper quadrant pain 1
Gastrointestinal distress 1
bewilderment 1
more...
Drug
Imatinib 462
IL-2 268
Gleevec 258
Dasatinib 188
lysine 181
CSF 174
IFN-gamma 160
ROS 157
Dermatol 151
MAP 143
TEL 137
Monit 78
Growth hormone 70
Growth hormone 70
Leaf 55
Cardiovasc 51
MDS 51
G-CSF 42
CTX 40
uPA 38
Angiotensin II 38
ABC 38
GEO 36
Gel 36
CTX 31
CTX 31
Bosutinib 31
NVP 28
ROC 28
ETS 26
ICI 25
IL-11 24
EE2 24
ALA 23
MIL 23
Sorafenib 22
CAM 22
EPA 22
Herceptin 22
ascorbate 21
lactose 21
IFN-beta 21
MRC 20
vitamin E 20
Gefitinib 20
Erlotinib 18
NADH 18
caffeine 17
DNase I 17
Kenyan 16
Asthma 16
THF 16
CPR 15
AZT 15
Imiquimod 15
Asn 15
Lenalidomide 15
AZT 14
ampicillin 14
Florisil 14
TAT 14
Vitamin A 14
Arsenic trioxide 13
citric acid 13
Norplant 13
Taxol 12
ADM 12
Gelatin 12
Doxycycline 11
Cetuximab 11
Nephron 11
Heme 11
Bortezomib 11
Simvastatin 11
p75 11
niacin 10
VCR 10
Rituximab 10
G418 10
Azithromycin 10
CCL 10
CIA 10
Fragment 9
Dakar 9
Cremophor EL 9
BLM 9
ETA 9
Docetaxel 9
NBT 9
Photofrin II 9
Glucagon 9
Estrogens 9
PDL 9
ENT 9
Mutagen 9
NaI 8
Photofrin 8
IL-1ra 8
NaI 8
Dial 8
Emodin 8
NaI 8
Adriamycin 8
Epigallocatechin 8
Retinoic acid 8
NaI 8
TTC 8
Cilengitide 8
Everolimus 8
Emodin 8
Ethanol 8
TAK 8
NOV 8
Albumin 8
Biopolymers 7
Lovastatin 7
Forskolin 7
Itraconazole 7
nitroglycerin 7
PFA 7
Bifidobacterium 7
HCH 7
CTC 6
Glutathione 6
Nitric Oxide 6
KCL 6
TiO2 6
EPI 6
PTH 6
Raltegravir 6
Acyclovir 6
PCB 6
Urokinase 6
Activin 6
Zoledronic acid 6
PNT 6
PTC 6
ZnO 6
Indomethacin 6
GHRP 6
ACT 6
Alanine 6
Spectrum 5
SiO2 5
CTC 5
Portal 5
Amiloride 5
Paraffin 5
anti-CD33 5
Tarceva 5
Vitamin K 5
Fraction 5
OTC 5
FAD 5
DHT 5
ADR 5
Horizon 5
Glycyrrhiza 5
Nephron 5
NH3 5
more...
Enzyme
focal adhesion kinase 44029
mitogen-activated protein kinase 3173
ERK 3081
protein kinase 1235
protein kinase C 772
MEK 675
phosphatidylinositol 3-kinase 650
luciferase 446
caspase-3 422
phosphoinositide 3-kinase 353
FPS 347
GSK 247
reverse transcriptase 236
phospholipase C 227
AMP-activated protein kinase 213
proteasome 208
AMPK 199
PARP 177
AMPK 158
calcineurin 148
PDK1 148
ACS 138
alkaline phosphatase 137
thrombin 132
MAP 130
superoxide dismutase 130
glutathione S-transferase 127
NO synthase 115
ATPase 108
cdc2 106
urokinase-type plasminogen activator 105
IKK 103
RNA polymerase 98
APC 95
collagenase 93
catalase 88
MMP 86
alanine aminotransferase 86
lactate dehydrogenase 84
NADPH oxidase 78
caspase-9 75
aspartate aminotransferase 72
peroxidase 72
caspase-8 71
NADPH oxidase 66
beta-lactamase 58
renin 52
AOR 51
transcriptase 50
CD10 50
arginase 49
phosphodiesterase 48
NOS 48
ACE 44
trypsin 44
aldehyde dehydrogenase 42
P-glycoprotein 40
protein phosphatase 2A 40
STR 40
creatine kinase 35
glyceraldehyde-3-phosphate dehydrogenase 35
DNA methyltransferase 34
BMT 34
PTPase 34
myosin light chain kinase 33
glutathione peroxidase 33
CaMKII 32
MEKK1 32
aldehyde dehydrogenase 31
phospholipase A2 29
RNase 29
RNase 29
aldehyde dehydrogenase 29
caspase-1 29
adenylate cyclase 29
aldehyde dehydrogenase 29
aldehyde dehydrogenase 29
GAS 29
AST 28
topoisomerase 27
MMP-3 27
topoisomerase 26
PKG 26
MDR 26
lysyl oxidase 25
demethylase 25
lipase 25
matrix metalloproteinase 9 23
plasmin 23
tyrosine hydroxylase 23
CD13 23
neuraminidase 23
matrix metalloproteinase 2 23
phospholipase D 22
CEP 22
lysozyme 22
thyroid peroxidase 22
transglutaminase 22
phosphoenolpyruvate carboxykinase 22
CEP 21
CYP3A4 21
beta-galactosidase 20
transketolase 20
STK11 19
acetylcholinesterase 19
HK2 19
complex I 18
tissue plasminogen activator 18
polo-like kinase 1 18
guanylate cyclase 18
MIP 17
TOR 17
GRK5 17
LPL 16
histone acetyltransferase 16
CPR 16
enolase 16
endonuclease 16
hexokinase 16
chloramphenicol acetyltransferase 16
glucose-6-phosphate dehydrogenase 16
hyaluronidase 15
glucose-6-phosphatase 15
PAM 15
asparaginase 15
phosphoenolpyruvate carboxykinase 15
phosphoenolpyruvate carboxykinase 15
prostate-specific antigen 15
elastase 15
thymidine kinase 14
prolidase 14
MPP 14
PAH 14
glucokinase 14
CPT 14
ALDH 14
glutathione reductase 14
pyruvate kinase 14
acid phosphatase 14
TAT 14
apyrase 14
xanthine oxidase 13
kinesin 13
CAD 13
CAD 13
CAD 13
glyceraldehyde-3-phosphate dehydrogenase 13
granzyme B 13
dihydrofolate reductase 13
DNA polymerase 12
sialidase 12
glyceraldehyde-3-phosphate dehydrogenase 12
glyceraldehyde-3-phosphate dehydrogenase 12
inositol 3-kinase 12
adenosine deaminase 12
adenosine deaminase 12
glyceraldehyde-3-phosphate dehydrogenase 12
farnesyltransferase 12
TdT 12
ornithine decarboxylase 12
more...
Compound
tyrosine 4311
ABL 4281
BCR 3722
Dec 2878
DNA 2463
Clin 1267
oxygen 896
arginine 887
glucose 876
calcium 833
water 784
serine 600
TEC 530
TNF 496
ATP 476
MEK 472
threonine 446
MDA 420
nitric oxide 402
methionine 358
sodium 344
phosphate 324
MTT 303
lysine 270
hydrogen 270
acetate 266
cAMP 248
Tyrosine 242
cysteine 242
Insulin 236
iron 203
Phe 193
sulfate 174
alanine 173
GTP 163
leucine 161
ASA 158
PAM 151
Asp 149
zinc 145
ACS 138
ACS 138
TEL 137
His 135
Vimentin 132
MAP 130
nitrogen 126
copper 125
Gly 121
COS 119
retinoic acid 114
pyrimidine 114
pyrimidine 112
urea 109
ethanol 109
ADP 106
galactose 104
glutamate 104
TNM 103
proline 102
NH2 100
ammonium 97
AMP 97
salt 95
GSH 94
GSH 94
potassium 93
THP 90
THP 89
ADP 89
ADP 89
H2O2 88
bromide 86
Cbl 84
methanol 83
creatinine 82
acetonitrile 82
HCl 81
Ang II 79
iodine 78
Cardiol 76
Phosphatidylinositol 76
PEG 75
tryptophan 75
CO2 73
manganese 70
titanium 68
Wortmannin 68
boron 66
cadmium 65
glutamine 64
PMA 63
N-acetylcysteine 62
cGMP 61
Curcumin 60
Ile 59
valine 59
silver 59
TEM 58
chromium 56
Pac 56
PMA 55
PEG 54
selenium 52
mercury 52
nickel 52
Collagen 51
aluminum 50
acetic acid 49
tryptophan 49
Angiotensin II 49
Rapamycin 49
SDS 48
tryptophan 48
tryptophan 48
NBS 47
GAP 47
dUTP 46
DDP 45
vitamin D 45
nitrate 45
HNO3 42
formic acid 42
Nitrate 42
formic acid 42
formic acid 42
formic acid 42
formic acid 42
formic acid 42
formic acid 42
formic acid 42
pyridine 42
formic acid 42
formic acid 42
HNO3 41
HNO3 41
HNO3 41
HNO3 41
HNO3 41
HNO3 41
HNO3 41
HNO3 41
hydroxide 41
HNO3 41
HNO3 41
HNO3 41
HNO3 41
HNO3 41
HNO3 41
HNO3 41
HNO3 41
HNO3 41
HNO3 41
HNO3 41
HNO3 41
EDTA 41
HNO3 41
HNO3 41
HNO3 41
HNO3 41
more...