Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: EC:2.7.10.2 (focal adhesion kinase)
 44,029 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The prevalence of urogenital infection caused by Chlamydia trachomatis was examined in 100 non-pregnant women with cervicitis, and 100 healthy women, in San Salvador City, El Salvador. Pharmacia Chlamydia EIA test was used for the detection of chlamydial antigen in urethral and cervical specimens from all the women. Direct immunofluorescence was used for confirmative tests on the EIA positive and the negative gray zone samples. C. trachomatis antigen was detected in 28% of the women with cervicitis compared with 5% in the group of healthy women (P < 0.001). The cervicitis group were also screened for Neisseria gonorrhoeae which was isolated from 12% of them. One strain out of 12 was beta-lactamase producing (PPNG). Five per cent of the women with cervicitis had simultaneous C. trachomatis and N. gonorrhoeae infections.
Int J STD AIDS
PMID:Prevalence of urogenital Chlamydia trachomatis infection in El Salvador. II. Gynaecology outpatients. 128 20

One-hundred and twenty-nine pregnant women in labour (age range 15-46 years; median age 23) and 42 infants born to chlamydia-positive mothers (age range 5-15 days; median age 10) were investigated to estimate the prevalence and incidence, respectively, of Chlamydia trachomatis infection in San Salvador, El Salvador. Urethral and cervical samples were obtained from all women and conjunctival specimens were taken from both eyes of each child. The chlamydial antigen was detected with the commercial Pharmacia Chlamydia EIA kit. Direct immunofluorescence (DFA) (Syva MicroTrak) was used for confirmation. In the newborns both EIA and DFA tests on direct preparations from ocular smears were performed on all the samples. The prevalence of chlamydial infection in pregnant women was 44% (57/129). The incidence of chlamydial infection in neonates was 64% (27/42), and the majority of the infected children (56%) had conjunctivitis. Referring to individuals rather than specimens the sensitivity of EIA tests on conjunctival samples from the infants was low (37%) as compared with 91% on urethral and cervical specimens from the pregnant women.
Int J STD AIDS
PMID:Prevalence of urogenital Chlamydia trachomatis infection in El Salvador. I. Infection during pregnancy and perinatal transmission. 154 65

The analysis of a representative survey of households (n = 968) in a San Francisco Bay Area county provides strong evidence for the role of problem drinking as a risk factor for sexually transmitted diseases independent of drinking patterns and drug use. Among women, age, race, early age at first intercourse, history of multiple partners, drinking patterns, as well as current symptoms of problem drinking were all associated with reported STD rates. Stepwise logistic regression analysis showed, however, that female problem drinkers are nearly four and a half times more likely (adjusted O.R. = 4.65, 95% C.I. = 1.30, 16.70) than other women to have had STDs independent of all these potential risk factors. Problem drinking puts women at a greater risk for STDs than a history of multiple sex partners (adjusted O.R. = 2.75, 95% C.I. = 0.98, 7.75). This finding is also observed among men, among whom STDs were associated with a history of multiple sex partners (adjusted O.R. = 4.12, 95% C.I. = 1.90, 8.94) and the lifetime prevalence of drinking problems (adjusted O.R. = 4.95, 95% C.I. = 2.13, 11.50). Frequent bar-going, drunkenness episodes, high volume drinking, feeling disinhibited while drinking and drug use increase the risk for STDs via their effects on the rate of sex partner change. Problem drinking determines STD rates independent of these factors. The implications of these findings for future research and health policy are discussed.
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PMID:Behavioral risk factors for sexually transmitted diseases in American households. 160 76

The 1st generation of serological tests for anti-HIV-1 gave so many false positives with African sera that it was wrongly postulated that the virus was endemic in Africa. As there is no simian or other virus sufficiently closely related to HIV-1 as to suggest a recent common ancestor, the evolution of HIV-1 is obscure and there is no evidence to support the hypothesis of an African origin. However, the similarity of HIV-2 to SIV and its geographical distribution do suggest an evolution of this virus in west Africa. The earliest anti-HIV-1 positive serum was from a subject in Kinshasa in 1959. Seroprevalence rose in pregnant women in Kinshasa from 0.25% in 1970 to 3.0% in 1980 and 5.7% in 1986. When 2 sexually promiscuous groups are compared, seropositivity rose sharply in female prostitutes in Nairobi from 4% in 1981 to 59% in 1984 and 64% in 1986, a curve which is approximately parallel to, but 3 years later than that of homosexual males in San Francisco. In central and east Africa, HIV-1 is now epidemic from Congo to Kenya and from Uganda to Zimbabwe. In west Africa, both HIV-2 and HIV-1 are epidemic; seroprevalence of HIV-2 is highest in southern Senegal, Guinea-Bissau, and Cote d'Ivoire: HIV-1 had the highest frequency in Cote d'Ivoire and Ghana. HIV-2 has not been reported, and HIV-1 is pre-epidemic in Africa north of the Sahara, Nigeria, Angola, MOzambique, and southern Africa, being found at significant frequency only in female prostitutes, patients with STD, or, in Morocco and South Africa only, in male homosexuals. Seroprevalence is greatest in female prostitutes and patients with STD; infection is more frequent in urban than in rural populations, except in Uganda. The peak frequency is at 30-34 years in males and 20-24 years in females. Other groups at risk are infants born to infected mothers, and those requiring blood transfusions, especially preschool children, patients with sickle cell disease, and pregnant women. The doubling time for seropositivity is about 1 year in the sexually active age range in some populations. Even at existing seroprevalence, decimation or worse of the most productive age groups is inevitable during the next few years in certain countries. Accelerated progression of the disease during pregnancy will lead to higher morbidity and mortality among fertile women than among men. The recent reductions in infant and childhood mortalities will be reversed, and populations may decline. Devastating social, economic, and demographic consequences are forecast. (author's)
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PMID:Seroepidemiology of human immunodeficiency viruses in Africa. 319 Dec 7

Electrothermal atomic absorption spectrometry with a temperature-stabilizing platform and palladium(II) nitrate-magnesium nitrate-barium nitrate matrix modifier combination was used to measure total selenium concentrations in 0.5-ml samples of human urine. The method was validated by analysis of desiccated, standard urine samples (SRM 2670) from NIST. The peak height response was linear from 0 to 150 micrograms Se/liter urine with a sensitivity of 0.001 absorbance unit/micrograms Se/liter and a detection limit of 6 micrograms Se/liter (P = 0.05) for a single measurement. Total urinary selenium concentrations and urine volumes of 24-h samples from 28 healthy adult subjects on self-selected diets and living in San Angelo, Texas were measured. Daily total urinary excretions of 16 male and 12 female subjects (mean +/- SD) were 28 +/- 26 and 34 +/- 25 micrograms Se/day, respectively. A single subject taking 300 micrograms Se/day in the form of aqueous SeO2 as a dietary supplement excreted 232 micrograms Se/day. The unsupplemented subjects' daily selenium excretions correspond to a mean dietary intake of approximately 60 micrograms/day.
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PMID:Palladium(II), magnesium(II), and barium(II) nitrate combinations for matrix modification in electrothermal atomic absorption measurement of total selenium in human urine. 797 75

To effectively implement a school-based STD/HIV prevention intervention program developed by a community-based agency, several issues must be addressed to build a collaborative partnership between the agency and the school district. Steps taken by the Division of Adolescent Medicine, University of California, San Francisco, in achieving partnership with a local urban school district are outlined. The process of recruiting school district administrators, health education liaisons, teachers, parents, and students is emphasized.
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PMID:Implementing a school-based STD/HIV prevention intervention: collaboration between a university medical center and an urban school district. 841 37

A three-group quasi-experimental design contrasted the responses of rescue workers to the 1989 Loma Prieta earthquake Interstate 880 freeway collapse (n = 198) with responses to critical incident exposure of Bay Area Controls (n = 140) and San Diego Controls (n = 101). The three groups were strikingly similar with respect to demographics and years of emergency service. The I-880 group reported higher exposure, greater immediate threat appraisal, and more sick days. The three groups did not differ on current symptoms. For the sample as a whole EMT/Paramedics reported higher peritraumatic dissociation compared with Police. EMT/Paramedics and California road workers reported higher symptoms compared with Police and Fire personnel. Nine percent of the sample were characterized as having symptom levels typical of psychiatric outpatients. Compared with lower distress responders, those with greater distress reported greater exposure, greater peritraumatic emotional distress, greater peritraumatic dissociation, greater perceived threat, and less preparation for the critical incident.
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PMID:Stress responses of emergency services personnel to the Loma Prieta earthquake Interstate 880 freeway collapse and control traumatic incidents. 875 Apr 52

We aim to assess the prevalence of HIV sexual risk behaviours and substance use among runaway and homeless adolescents in San Francisco, Denver and New York City. Survey data were examined from 775 runaway and homeless adolescents recruited from street settings and youth agencies during 1992/1993. Nearly all (98%) reported having engaged in sexual intercourse, of whom 49% first had intercourse by the age of 13. Condom use during all vaginal intercourse in the previous 3 months was reported by 42%. Among males, 23% indicated that they had exchanged sex for money, as did 14% of the females. Ninety-seven per cent had used alcohol or drugs and 21% had injected drugs. Overall, 75% reported having had sex while under the influence of alcohol or drugs. Systematic epidemiological studies of this population and the development of innovative interventions are essential to reduce the threat of HIV among runaway and homeless youth.
Int J STD AIDS 1997 Feb
PMID:Prevalence of sexual risk behaviour and substance use among runaway and homeless adolescents in San Francisco, Denver and New York City. 906 10

Consistent condom use represents the primary HIV prevention strategy for US women. Baseline and follow-up interviews conducted in 1993 with 128 African-American women 18-29 years of age recruited from a low-income community in San Francisco, California, sought to identify the predictors of consistent condom use. 90.6% of respondents were unmarried, 71.9% had at least 1 child, and 71.9% received public assistance. Compared with inconsistent condom users, the 36 women (28.1%) who reported condom use on all occasions were significantly more likely to have high assertiveness communication skills (odds ratio (OR), 13.0; 95% confidence interval (CI), 3.9-43.8), not desire pregnancy (OR, 8.6; 95% CI, 2.2-34.5), have high sexual self-control over condom use (OR, 7.6; 95% CI, 2.5-23.0), perceive themselves to have control over their sexual partner's condom use (OR, 6.6; 95% CI, 2.1-20.6), be under 25 years of age (OR, 5.8; 95% CI, 1.8-19.2), and be in a relationship with a partner with a low commitment to the relationship (OR, 3.3; 95% CI, 1.2-9.4). Baseline level of condom use was the best predictor of condom use at the 3-month follow-up interview. Specifically, women who were consistent condom users at baseline were 6.3 times more likely to be consistent users at follow-up. These findings underscore the need to contextualize women's condom use and HIV prevention within the framework of gender relations.
Int J STD AIDS 1998 Mar
PMID:Gender-related correlates and predictors of consistent condom use among young adult African-American women: a prospective analysis. 953 Aug 98

Men who have sex with men (MSM) in gay male communities do not always use condoms when having anal sex. Reasons for such risky behavior include men's objections to the lack of spontaneity demanded from condom use, decreased sensation, and condom breakage. Reality, a polyurethane pouch designed to line the vagina, was developed mainly to provide women with a contraceptive and STD prevention option. A removable inner ring and fixed outer ring keep the device in place. Some MSM use Reality when having anal sex. 750 free Reality kits were distributed by the STOP AIDS Project in San Francisco at venues frequented by MSM. Kits included 2 female condoms, instructions, a self-administered questionnaire on the users' experiences with Reality, and a stamped return envelope. 108 surveys were returned, with 100 MSM reporting use of Reality during the past 6 months in 147 episodes of insertive and 187 episodes of receptive anal sex. 86 men reported that they would use Reality again, and 54 said they would rather use Reality than conventional male condoms. Generally most liked about Reality were its heightened sensitivity and spontaneity, while insertion difficulties and high cost were the factors least liked. Acceptability was higher among MSM who were HIV-positive, in nonmonogamous relationships, or who had serodiscordant sex partners. Negative experiences included difficulty inserting (33%), irritation (17%), bunching up (12%), unpleasant texture (10%), and noise (9%). Breakage was reported 3 times in 334 episodes of use. Reality appears to be a welcome alternative for some MSM who do not consistently use penile condoms. Although use of the method probably reduces HIV transmission compared to unprotected anal sex, more research is needed to definitively assess its effectiveness as a risk reduction method for MSM.
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PMID:Experiences of 100 men who have sex with men using the Reality condom for anal sex. 1007 May 90


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