Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:2.7.10.2 (focal adhesion kinase)
 44,029 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Cryostat sections of normal skin from 57 white adults were examined by direct and indirect immunofluorescence for immunoglobulins, complement factors, and transferrin. The results for basement membrane zone (BMX) were significantly different for the 11 face and 46 non-face biopsies: in the face, IgM was found in five, IgG in two, IgA in one, and C3 in none, whereas, in non-face, IgM was present in six, IgG in none, IgA in one, and C3 in five. The results for dermal vessel walls (DV) were not apparently different for face and non-face; in the 57 biopsies IgM was present in one, IgG in none, IgA in one, and C3 in one. The 11 biopsies from the face and 26 of the non-face biopsies were examined further. No IgD or C4 was identified, but one case (scalp) showed BMZ Clq, properdin, and transferrin, and in two cases (one face, one non-face) DV properdin was found. Cytoid bodies (IgM and IgA) were present in moderate numbers in one case; all other positive reactions were finely granular.
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PMID:Immunoglobulin and complement in normal skin. 37 44

At the BMX Cycling European Championship in 1989 with 976 participants of both sexes, aged between six and 40 years, all injuries were registered. A total of 6.3% of the participants sustained injuries (1.6% per individual start), 52.5% required medical attendance and 3.3% necessitated hospital admission. Women were injured twice as frequently as men. Most injuries, 72.1%, were minor, 6.6% were fractures with 75% of the fractures affecting the upper limbs. BMX bicycle riding has the high injury risk of 1190 injuries per 1000 competition hours.
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PMID:Injuries at the BMX Cycling European Championship, 1989. 209 28

Over five years 415 children attended the accident and emergency department at Whakatane Hospital for injuries sustained while riding pedal cycles, four of whom died and 17% required admission to hospital. Twenty-eight percent of riders were less than eight years old, although it is known that children are not safe on roads up to this age. Forty-five children were passengers, mostly under five years of age and suffering from lower limb injuries from catching feet in wheel spokes. BMX bicycle riders were overrepresented among the injured. All deaths and permanent incapacity were a result of brain damage and could probably have been prevented by the use of approved safety helmets. There is a clear need for communities to address these safety issues.
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PMID:Injuries to child cyclists in the Bay of Plenty. 237 64

The case of an adolescent BMX rider suffering from bilateral intraarticular loose bodies of the elbow is reported. He underwent surgery to remove these. He is now asymptomatic and has resumed BMX riding. This is the first overuse injury to be ascribed to this sport. It is probably due to repetitive valgus compression stresses at the radiocapitellar joint during the acrobatic manoeuvres of a typical BMX riding session.
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PMID:Bilateral intra-articular loose bodies of the elbow in an adolescent BMX rider. 262 36

The incidence and severity of injuries occurring on BMX bicycles coming to an Accident and Emergency department (A&E) of a children's hospital have been studied prospectively during a 4-month period in 1984 and compared with the same calendar period 1 year previously, before the increase in BMX sales had occurred. The majority of bicycle accidents in the 1984 period occurred on BMX models. There was a marked increase in the number of injuries seen in 1984 (288) in comparison with 1983 (188), reflecting the increased use of bicycles by children due to the current popularity of BMX models. Although there was an increase in minor injuries in 1984 (182) compared with 1983 (112), the number of severe injuries was less-56 in 1984 (20 per cent) and 68 in 1983 (37 per cent). BMX bicycles, although increasing the number of A&E attendances, have not caused a rise in the number of severe injuries related to bicycles in Edinburgh.
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PMID:BMX bicycle injuries in children. 377 Aug 82

A comparison has been made between BMX bicycle accidents and those occurring when children ride other types of bicycle. The injuries sustained are compared to see if the clinical impressions that BMX are more dangerous, and produce more facial injuries, are correct. This was found not to be true as half the children involved rode BMX bicycles, and the injuries sustained were similar to those occurring to non BMX riders. BMX riders had a lower proportion of serious injuries than riders of racing cycles. There were a large number of head injuries needing admission to hospital, but BMX riders had fewer head injuries than the other groups. The use of protective headgear was minimal. Facial injuries were evenly distributed between BMX and non BMX groups. The major cause of accidents to BMX riders was performing stunts but, overall, poor cycling technique associated with minimal cycling experience were the factors common to 50% of accidents.
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PMID:BMX bicycles: accident comparison with other models. 383 94

Three hundred new cases of bicycle accidents were seen in the accident and emergency department in 60 consecutive days. Fifty six per cent were related to ordinary cycles and 44% to BMX cycles. Significantly more children on BMX cycles were boys (94% v 76% on ordinary cycles). Those on BMX cycles were somewhat older and more had had previous accidents. By means of a proforma we investigated the nature and causes of the accidents, recorded the type of injury, and compared accidents on the two groups of bicycles. Forty children had fractures and the incidence on BMX machines was almost twice that on conventional bicycles as were serious injuries and admissions to hospital. Twenty one children had concussion, 18 broke teeth, 53 fell head first over handlebars, and 131 had injuries above the neck. Significantly more children on ordinary cycles (53%) had injuries above the neck than those on BMX cycles (31%). Difficulties and methods of preventing the increasing number of cycle accidents are discussed.
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PMID:BMX compared with ordinary bicycle accidents. 401 51

One hundred children presented over 40 days with BMX bike injuries, 40 of which had been sustained while trying to perform stunts. Injuries in this series were compared with previously reported injuries from accidents on ordinary bicycles. BMX bike injuries differed little from ordinary bike injuries except in the greater proportion of injuries due to stunts and the smaller incidence of head injuries.
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PMID:Injuries to children riding BMX bikes. 643 37

Two cases of a severe scrotal injury--a new, hitherto unreported pattern of injury peculiar to BMX bicycle riding--are reported. Two such injuries occurring within a short period of time prompted us to suggest that scrotal protection, as well as a crash helmet and limb padding, should be made standard safety equipment for all BMX bicycle riders who engage in the sport of jumping.
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PMID:BMX handlebar. A threat to manhood? 716 50

The Bmx sequence was identified and cloned during our search for novel tyrosine kinase genes expressed in human bone marrow cells. Bmx cDNA comprises a long open reading frame of 675 amino acids, containing one SH3, one SH2 and one tyrosine kinase domain, which are about 70% identical with Btk, Itk and Tec and somewhat less with Txk tyrosine kinase sequences. The amino terminal sequences of these four tyrosine kinases are about 40% identical and each contains a so-called pleckstrin homology domain. The 2.7 kb Bmx mRNA was expressed in endothelial cells and several human tissues by Northern blotting and an 80 kD Bmx polypeptide was detected in human endothelial cells. Immunoprecipitates of COS cells transfected with a Bmx expression vector and NIH3T3 cells expressing a Bmx retrovirus contained a tyrosyl phosphorylated Bmx polypeptide of similar molecular weight. The BMX gene was located in chromosomal band Xp22.2 between the DXS197 and DXS207 loci. Interestingly, chromosome X also contains the closest relative of BMX, the BTK gene, implicated in X-linked agammaglobulinemia. The BMX gene thus encodes a novel nonreceptor tyrosine kinase, which may play a role in the growth and differentiation of hematopoietic cells.
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PMID:BMX, a novel nonreceptor tyrosine kinase gene of the BTK/ITK/TEC/TXK family located in chromosome Xp22.2. 797 Jul 27


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