Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:2.7.10.2 (focal adhesion kinase)
 44,029 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

FNBP1, FNBP1L, CIP4/TRIP10, FNBP2, SRGAP1/ARHGAP13, SRGAP2/ARHGAP14, ARHGAP4, FCHSD1, and FCHSD2 constitute the FCFBS superfamily characterized by FES-CIP4 homology (FCH) domain, Formin-binding FNBP1-FNBP2 homology (FBH) domain, and SRC homology 3 (SH3) domain. During genome-wide searching for human genes encoding FCH domain molecules, we identified the FCHO2 gene by using bioinformatics. DKFZp451B033 (AL831971.1) was the representative cDNA derived from human FCHO2 gene, while FLJ32208 (AK056770.1) was a chimeric cDNA generated by the recombination between FCHO2 and CSH1 genes. MGC63242 (BC052456.1) rather than 5832424M12 (AK031041.1) was the representative cDNA derived from mouse Fcho2 gene. FCHO2 gene, consisting of 26 exons, was mapped to human chromosome 5q13.2. Human FCHO2 (810 aa) showed 94.6% total-amino-acid identity with mouse Fcho2 (809 aa), and 50.4% total-amino-acid identity with human FCHO1. Drosophila CG8176 (NP_788613.1) and C. elegans 2B609 (NP_493947.1) were homologs of mammalian FCHO2 and FCHO1. FCHO-homologous (FOH) domain (codon 527-810 of human FCHO2) was identified as the novel domain conserved among FCHO homologs. Human FCHO2, FCHO1, Drosophila CG8176 and C. elegans 2B609 were found consisting of N-terminal FCH domain and C-terminal FOH domain. This is the first report on identification and characterization of evolutionarily conserved FCHO homologs as well as the novel FOH domain.
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PMID:Identification and characterization of human FCHO2 and mouse Fcho2 genes in silico. 1525 87

Kidney renal clear cell carcinoma (KIRC) is one of the most common cancers globally, with an overall poor prognosis. The Janus kinase (JAK) family plays an essential role in cellular mechanisms such as proliferation, metastasis, invasion, and immunity. In our study, various web-portals were used to explore the expression and clinical significance of JAK3 in KIRC. JAK3 expression was significantly up-regulated in KIRC tissues. Patients with KIRC having high JAK3 levels displayed a substantially decreased disease-free survival rate and overall survival rate. Significant correlations were obtained between JAK3 expression and the abundance of immune cells and immune biomarker sets. Enrichment function analysis revealed that gene function significantly correlated with JAK3, which was primarily associated with the immune response, JAK-STAT signaling pathway, Ras signaling pathway via several cancer-related kinases, miRNAs, and transcription factors. Moreover, we also identified several kinase, miRNA or transcription factor targets of JAK3 in KIRC. The hub genes (JAK3, FCHO1, INSl3, DEF6, and GPR132) were associated with the activation or inhibition of several famous cancer related pathways. Our results demonstrated that JAK3 is a potential biomarker and associated with immune infiltration in KIRC.
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PMID:JAK3 is a potential biomarker and associated with immune infiltration in kidney renal clear cell carcinoma. 3257 38