Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:2.7.10.2 (focal adhesion kinase)
 44,029 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Defibrillation by minimally trained ambulance technicians can significantly improve survival after out-of-hospital cardiac arrest in communities of all sizes. However, special consideration must be given to the development of such services in small communities, chiefly because of problems associated with the low volume of true emergency calls. Communities considering implementing programs by which defibrillation is performed by the emergency medical technician (EMT-D) must first evaluate their ambulance response times and, if inadequate, alter their system of ambulance response. After implementation of such a program, a permanent, formal skill maintenance program must be established. Defibrillation protocols must allow for the fact that many patients will refibrillate after successful conversion, yet no advanced care beyond the defibrillator will generally be available. Finally, every community instituting an EMT-D program must maintain a system of monitoring EMT performance and patient outcome that documents acceptable survival-to-discharge rates as well as the safety of the program. For smaller communities a regional or statewide evaluation system may be preferable to individual community programs.
Circulation 1986 Dec
PMID:Special considerations for defibrillation performed by emergency medical technicians in small communities. 377 28

The purpose of this study was to describe the frequency content of the electromyogram (EMG) recorded during shivering and determine if the EMG power spectrum changed as a function of the shivering duration. Six semi-nude males were exposed to cold air (5 degrees C, 20% rh) for 80 min while quietly sitting. Rectal (Tre) and mean skin (Tsk) temperatures were recorded. Shivering of the masseter muscle was determined using bipolar surface electrodes. The EMG was amplified, recorded, and subsequently digitized at 2048 Hz. The power spectrum was calculated from eight serial 0.25s EMG samples by Fourier analysis from a frequency of 4 through 480 Hz. The eight power spectra were averaged and centroid frequency (fc) calculated. During the first 10 min of exposure, Tsk rapidly dropped from 32.6 +/- 1.6 to 26.2 +/- 1.3 degrees C, then slowly declined reaching 22.5 +/- 0.7 degrees C after 80 min. Tre rose from 37.1 +/- 0.1 to 37.4 +/- 0.1 degrees C, declining after 40 min to 37.2 +/- 0.1 degrees C. Shivering was observed within 5 min after entering the cold chamber. EMG activity after 10 min exhibited an fc of 177.2 +/- 6.2 Hz. When power was integrated over 60 Hz bandwidths, the predominant frequency band of the EMG power spectrum was 60-120 Hz. Although shivering intensity increased with time, the EMG power spectrum exhibited no significant changes. These results suggest that the EMG power spectrum during shivering did not exhibit changes characteristic of muscle fatigue or muscle cooling during the 80-min cold air exposure.
Aviat Space Environ Med 1986 Dec
PMID:Power spectral analysis of the surface electromyogram during shivering. 380 Aug 14

The effect of ganglionic blockade (GB) and subsequent i.v. infusion of adrenaline (AD), noradrenaline (NA), isoproterenol (IP), and angiotensin II (AII) on thoracic duct lymph flow (LF) and transcapillary escape rate of plasma proteins (FER) was studied in anaesthetized (Nembutal), paralyzed (pancuronium), and artificially ventilated dogs. The carotid artery, the external jugular vein, and the thoracic duct were cannulated. Following a control period, GB was performed by pentolinium tartrate and thereafter the other drugs were infused in a random sequence for 30-60 min with 1 h intervals. Mean arterial blood pressure was decreased from 125 to 90 mmHg by GB, it was increased by 36 mmHg by AD, 41 mmHg by NA, and 44 mmHg by AII, and was decreased by 27 mmHg by IP. LF was about 38 microliter/min/kg before GB and was not changed systematically by GB, because either the sympathetic tone was rather weak or the intrinsic contractions and the tone of lymphatics were reduced by GB. FER was not affected by GB. LF increased by 9 microliter/min/kg (control 36 microliter/min/kg) during AII infusion, probably due to increased lymph formation; the latter can be concluded from the 68% increase in FER. NA raised LF by 15 microliter/min/kg (control 44 microliter/min/kg) probably due to alpha-adrenergic stimulation of the intrinsic contractions of lymphatics; lymph formation seemed not to be affected because FER was not changed systematically. AD enhanced LF by 29 microliters/min/kg (control 39 microliters/min/kg).(ABSTRACT TRUNCATED AT 250 WORDS)
Z Lymphol 1986 Dec
PMID:[Effect of ganglionic blockade and subsequent i.v. infusion of catecholamines and angiotensin II on the formation and transport of lymph. Studies in anesthesized dogs and a review of the literature]. 382 39

A comparison has been made between BMX bicycle accidents and those occurring when children ride other types of bicycle. The injuries sustained are compared to see if the clinical impressions that BMX are more dangerous, and produce more facial injuries, are correct. This was found not to be true as half the children involved rode BMX bicycles, and the injuries sustained were similar to those occurring to non BMX riders. BMX riders had a lower proportion of serious injuries than riders of racing cycles. There were a large number of head injuries needing admission to hospital, but BMX riders had fewer head injuries than the other groups. The use of protective headgear was minimal. Facial injuries were evenly distributed between BMX and non BMX groups. The major cause of accidents to BMX riders was performing stunts but, overall, poor cycling technique associated with minimal cycling experience were the factors common to 50% of accidents.
Arch Emerg Med 1985 Dec
PMID:BMX bicycles: accident comparison with other models. 383 94

In rehabilitating paraplegic patients the restoration of locomotion is often planned to enable the disabled person to use the wheelchair as little as possible or eventually even to abandon it. This objective is more easily obtained in those with incomplete spinal lesions. Applied with the view of restoring locomotion are various types of orthoses, but in the present paper the authors deal with functional electrical stimulation (hereinafter FES) as a means of restoring locomotion, demonstrating the advantages of FES over the use of classical orthoses. The paper offers an outline of the methodology of FES in spinal neural lesions, discusses the criteria of patient selection, giving indications and contraindications. The authors conclude by stating their belief that this treatment represents a new way of rehabilitating spinal paralysed patients which will sooner or later become part of the routine rehabilitation of paraplegic patients.
Paraplegia 1985 Dec
PMID:Functional electrical stimulation as an orthotic means for the rehabilitation of paraplegic patients. 387 90

In 10 women, external cold and heat exposures were performed both in the middle of luteal phase (L) and in the early follicular phase (F) of the menstrual cycle. Serum progesterone concentrations in L and F averaged 46.0 and 0.9 nmol X l-1, respectively. The experiments took place between 3:00 and 4:30 A.M., when the L-F core temperature difference is maximal. At neutral ambient temperature, esophageal (Tes), tympanic (Tty), rectal (Tre), and mean skin (Tsk) temperatures averaged 0.59 degrees C higher in L than in F. The thresholds for shivering, chest sweating, and cutaneous vasodilation (heat clearance technique) at the thumb and forearm were increased in L by an average of 0.47 degrees C, related to mean body temperature [Tb(es) = 0.87Tes + 0.13 Tsk] and to Tes, Tty, Tre, or Tsk. The above-threshold chest sweat rate and cutaneous heat clearances at the thumb and forearm were also enhanced in L, when related to Tb(es) or time. The metabolic rate, arm blood flow, and heart rate at thermoneutral conditions were increased in L by 5.0%, 1.1 ml X 100 ml-1 X min-1, and 4.6 beats X min-1, respectively. The concomitant increase in threshold temperatures for all autonomic thermoregulatory responses in L supports the concept of a resetting of the set point underlying the basal body temperature elevation in L. The effects of the increased threshold temperatures are counteracted by enhanced heat loss responses.
J Appl Physiol (1985) 1985 Dec
PMID:Influence of menstrual cycle on shivering, skin blood flow, and sweating responses measured at night. 407 97

With the aid of a specific rabbit antibody preparation to purified monoclonal murine IgE, two plaque-forming cell (PFC) assays have been developed for the detection and enumeration of mouse IgE-secreting cells. The first assay, utilizing protein A-coated sheep red cells (protein A-SRC), detected antibody-secreting cells on the basis of the class of the secreted Ig irrespective of antigen specificity. With this assay, 30% of the class of the viable cells of two distinct IgE-secreting hybridoma cell lines were scored as PFC. Under these conditions, plaques were not obtained with IgG1 or IgG2a-secreting hybridoma cells. The second PFC assay, which utilized SRC coated with ovalbumin (OA-SRC), enumerated cells secreting anti-OA IgE antibodies. Similar kinetic patterns were observed for the cellular (IgE PFC/spleen) and humoral (IgE serum levels) responses of (C57BL/6 x DBA/2)F1 mice following immunization with 10 micrograms of OA adsorbed to 1 mg of A1(OH)3. Thus, it is concluded that the reverse plaque assay detecting all IgE-secreting cells, as well as the antigen-specific IgE PFC assay, can be used for the quantitation of IgE responses at the cellular level.
Eur J Immunol 1980 Dec
PMID:The enumeration of mouse IgE-secreting cells using plaque-forming cell assays. 616 50

Thin-layer chromatography (TLC) was used to separate components in the basic and tar fractions of solvent refined coal (SRC-I) process solvent (PS) to obtain materials suitable for biological and chemical analysis. Those fractions eluted from TLC plates which were mutagenically active in the Ames/Salmonella assay were analyzed by gas chromatographic mass spectrometry (GCMS) for polycyclic azaarenes, polyaromatic primary amines (PAA) and carbazoles. In all materials tested, a strong correlation was observed between the concentration of PAAs in a given TLC region and the mutagenicity of that region in the Ames assay system. Conversely, azaarenes having 2--4 fused rings and carbazoles were present in both mutagenic and non-mutagenic TLC eluates. No PAAs were detected in mutagenically inactive TLC eluates. In comparison to the mutagenic tar fractions, the PS basic fraction contained relatively larger concentrations of 2- and 3-ringed components such as aminonaphthalenes and aminoanthracenes or aminophenanthrenes. The tar fractions, which were essentially devoid of aminonaphthalenes, had a higher average molecular weight and contained relatively higher concentrations of aminopyrenes.
Mutat Res 1981 Dec
PMID:Relative concentrations of polyaromatic primary amines and azaarenes in mutagenically active nitrogen fractions from a coal liquid. 617 60

Absorption of 14C-labelled poliovirus-2 to sedimentable solids of primary sludge samples collected from a secondary treatment facility during a 6-month period averaged 94%; for anaerobically digested sludge, 99%. The extent of virus adsorption was influenced by the amount of solids. Maximal adsorption occurred at or above 0.5% solids with sludge diluted with deionized water and above 1.5% solids when diluted with the respective particle-free sludge supernatants. A Tris-HCl buffer containing NaCl, glycerol, and serum was found to efficiently elute poliovirus-2 from primary sludge solids. By means of re-extraction and concentration by centrifugation (the TEC procedure), the average recoveries of poliovirus-2 were 92-94% based upon either infectivity or radioactivity analyses. Similarly, recoveries were 90-92% for poliovirus-2 in digested sludge. Maximum elution was dependent upon all four TEC buffer components and the restriction of solids to less than or equal to 1.0%. The procedure was found to be more efficient than glycine-NaOH and Freon procedures or elution with beef embryo extract. As adapted for effluents the procedure increased the yield and improved the consistency of virus recovery. The arithmetic mean titers and obtained during a monitoring study for primary and digested sludge were 4.2 X 10(5) and 5.1 X 10(3) plaque-forming units (pfu)/L; for primary, secondary, and final effluents 2.3 X 10(5), 4.7 X 10(3), and 4.7 X 10(2) pfu/L, respectively.
Can J Microbiol 1983 Dec
PMID:A multiple extraction--centrifugation method for the recovery of viruses from waste water treatment plant effluents and sludges. 632 80

Cryostat sections of adult and fetal tissues of the rat and human were investigated by a double immunoperoxidase technique for the presence of three developmentally-regulated mouse antigens, TEC-1,2,3. In the adult rats the TEC-1 antigen was detected on the epithelium of the isthmic portion of the oviduct, in some kidney tubuli, and in the brain; the TEC-2 antigen was distributed on the epithelium of various tissues, but it was also present on cells that may correspond to phagocytizing macrophages; the TEC-3 antigen was detected on endothelia of some vessels or capillaries. In rat fetuses only the TEC-1 antigen was detected; it was found on digestive tract epithelium and some kidney tubuli. In adult human tissues the distribution of TEC-1 antigen resembled that known for SSEA-1; the TEC-2 antigen was detected in some kidney tubules. In human midpregnancy fetuses the TEC-1 antigen was found in the same tissues as in adults; TEC-2 was detected in the thyroid gland. There was no staining of adult or fetal human tissues with TEC-03 antibody. The data show different patterns of expression of TEC-1,2,3 antigens among the species studied.
Cell Differ 1984 Dec
PMID:Localization of mouse TEC-1,2,3 antigens in adult and fetal tissues in the rat and human. 639 7


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