Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:2.7.10.2 (focal adhesion kinase)
 44,029 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

To study the influence of the menstrual cycle on whole body thermal balance and on thermoregulatory mechanisms, metabolic heat production (M) was measured by indirect calorimetry and total heat losses (H) were measured by direct calorimetry in nine women during the follicular (F) and the luteal (L) phases of the menstrual cycle. The subjects were studied while exposed for 90 min to neutral environmental conditions (ambient temperature 28 degrees C, relative humidity 40%) in a direct calorimeter. The values of M and H were not modified by the phase of the menstrual cycle. Furthermore, in both phases the subjects were in thermal equilibrium because M was similar to H (69.7 +/- 1.8 and 72.1 +/- 1.8 W in F and 70.4 +/- 1.9 and 71.4 +/- 1.7 W in L phases, respectively). Tympanic temperature (Tty) was 0.24 +/- 0.07 degrees C higher in the L than in the F phase (P less than 0.05), whereas mean skin temperature (Tsk) was unchanged. Calculated skin thermal conductance (Ksk) was lower in the L (17.9 +/- 0.6 W.m-2.degrees C-1) than in the F phase (20.1 +/- 1.1 W.m-2.degrees C-1; P less than 0.05). Calculated skin blood flow (Fsk) was also lower in the L (0.101 +/- 0.008 l.min-1.m-2) than in the F phase (0.131 +/- 0.015 l.min-1.m-2; P less than 0.05). Differences in Tty, Ksk, and Fsk were not correlated with changes in plasma progesterone concentration. It is concluded that, during the L phase, a decreased thermal conductance in women exposed to a neutral environment allows the maintenance of a higher internal temperature.
J Appl Physiol (1985) 1990 Dec
PMID:Decreased thermal conductance during the luteal phase of the menstrual cycle in women. 207 97

At the BMX Cycling European Championship in 1989 with 976 participants of both sexes, aged between six and 40 years, all injuries were registered. A total of 6.3% of the participants sustained injuries (1.6% per individual start), 52.5% required medical attendance and 3.3% necessitated hospital admission. Women were injured twice as frequently as men. Most injuries, 72.1%, were minor, 6.6% were fractures with 75% of the fractures affecting the upper limbs. BMX bicycle riding has the high injury risk of 1190 injuries per 1000 competition hours.
Br J Sports Med 1990 Dec
PMID:Injuries at the BMX Cycling European Championship, 1989. 209 28

To determine whether the viral replication functions of the adenovirus E1B 55K protein play a role in its ability to transform cloned rat embryo fibroblast cells in culture, we constructed an extensive series of insertion mutations throughout the 55K gene. The mutations were recombined into infectious virus and characterized for their abilities to produce stable 55K protein in HeLa cells, replicate virus in HeLa cells, express late viral proteins efficiently, and transform CREF cells following infection. Mutant 55K transforming activity in primary baby rat kidney cells was also assayed following DNA transfection. The functions required for viral replication are encoded in several patches of the 55K linear sequence, while the CREF transforming functions are sensitive to all of the insertions. An insertion at amino acid 380 created a mutant virus which was reduced in transforming activity, but was not reduced for viral replication. Therefore, a function required for efficient transformation of CREF cells can be separated from functions required for late gene expression and viral replication. Transformation of BRK cells following DNA transfection was reduced by complete disruption of the 55K protein gene, but was not significantly affected by any of the insertions.
Virology 1990 Dec
PMID:Dissection of functional domains in the adenovirus 2 early 1B 55K polypeptide by suppressor-linker insertional mutagenesis. 214 3

At present, the mechanism(s) underlying the reduced spontaneous and stimulated GH secretion in aging is still unclear. To obtain new information on this mechanism(s), the GH responses to both single and combined administration of GH-releasing hormone (GHRH; 1 microgram/kg iv) and arginine (ARG; 30 g infused over 30 min), a well known GH secretagogue probably acting via inhibition of hypothalamic somatostatin release, were studied in seven elderly normal subjects and seven young healthy subjects. Basal GH levels were similar in both groups, while insulin-like growth factor-I levels were lower in elderly subjects (76.7 +/- 9.2 vs. 258.3 +/- 29.2 micrograms/L; P = 0.01). In aged subjects GHRH induced a GH increase (area under the curve, 314.9 +/- 91.9 micrograms/L.h) which was lower (P = 0.01) than that in young subjects (709.1 +/- 114.4 micrograms/L.h). On the other hand, the ARG-induced GH increase in the elderly was not significantly different from that in young subjects (372.8 +/- 81.8 vs. 470.6 +/- 126.5 micrograms/L.h). ARG potentiated GH responsiveness to GHRH in both elderly (1787.1 +/- 226.0 micrograms/L.h; P = 0.0001 vs. GHRH alone) and young subjects (2113.0 +/- 444.3 micrograms/L.h; P = 0.001 vs. GHRH alone). The potentiating effect of ARG on the GHRH-induced GH response was greater in elderly than in young subjects (1013.0 +/- 553.5% vs. 237.9 +/- 79.1%; P = 0.0001); thus, the GH increase induced by combined administration of ARG and GHRH overlapped in two groups. In conclusion, these results show that, differently from the GHRH-induced GH increase, the somatotroph response to combined administration of ARG and GHRH does not vary with age. Our finding suggests that an increased somatostatinergic activity may underlie the reduced GH secretion in normal aging.
J Clin Endocrinol Metab 1990 Dec
PMID:Growth hormone (GH) responsiveness to combined administration of arginine and GH-releasing hormone does not vary with age in man. 222 4

Coypus (Myocastor coypus Molina) have recently colonized temperate regions of Europe in large numbers, originating from populations indigenous to subtropical regions of South America. Observations of coypu behavior in the wild and in enclosures under a temperate climate showed a preference for close proximity to water and frequent swimming bouts. Little change was observed in the semiaquatic habit in winter, despite high mortality during this period, particularly among young and adult male coypus. Evidence for constraints on thermal adaptation was sought from measurements in a thermostatic chamber of the resting metabolic rate (RMR) of young coypus caught from wild populations in France and of the body (Tb) and skin (Tsk) temperatures as a function of ambient temperature (Ta). A light heterothermic response with deep Tb falling by 0.8 degree C and stabilizing at a new level of 36.7 degrees C was observed in water and air at Ta below the lower critical temperatures. In common with other semiaquatic mammals, RMR (2.94 W/kg) was high relative to terrestrial mammals of equivalent body mass. Minimal thermal conductance was 0.10 W.kg-1.degree C-1 in air for Ta between -10 and +20 degrees C, and conductance varied in water from 0.24 to 1.18 W.kg-1.degrees C-1 for Ta between 5 and 35 degrees C. The physiological adaptations to cold and particularly the high insulative value of the fur (80-90% of the insulation) help to explain the successful extension of the coypu's range to temperate regions. Energetic costs were nevertheless high in cold water, suggesting that social factors may be implicated in severe winter mortality, particularly dominance hierarchy regulating the persistent use of water bodies even under freezing conditions.
Am J Physiol 1990 Dec
PMID:Temperature regulation of young coypus (Myocastor coypus) in air and water. 226 Jul 32

A non-clinic cohort of 525 homosexually active men from London and South Wales were recruited in 1988 for a study by interview of sexual behaviour. A sample of blood was tested for HIV-1 antibodies. Seropositivity in London was 9.2% compared with 3.4% in South Wales. Men who were not regular STD clinic attenders had a lower rate of seropositivity than did those who were regular attenders. Men who were seropositive reported more sexual partners with whom they had anal intercourse and also reported more episodes of syphilis. Overall, rates of seropositivity were lower than those reported by studies from STD clinics.
Genitourin Med 1990 Dec
PMID:Seroprevalence of HIV-1 infection in a cohort of homosexually active men. 226 39

In this article we estimate the total number of HIV seropositives in the Netherlands with an extended version of the Fast Back Calculation model. As a result we found between 5500 and 6500 seropositives for the end of 1987. This is considerably lower than earlier expectations. The distribution of incidence over time suggests that the HIV epidemic has passed its summit. We argue that the total number of HIV infected persons halfway 1990 lies somewhere between 7500 and 9000. With the estimated number of HIV seropositives we also predict minimum values for the AIDS incidence in future years. We expect the number of new AIDS cases to increase to over 600 per year in the mid-nineties. We briefly discuss the consequences of our findings for AIDS control. We underline the desirability of a policy directed at risk groups and apart from continuing existing preventive measures aimed at these groups we advocate paying more attention to i.v. drug users, visitors of STD clinics and travellers to and applicants for political asylum from endemic areas.
Ned Tijdschr Geneeskd 1990 Dec 22
PMID:[Estimate of the number of HIV-seropositive persons in The Netherlands; implications for the evolution of the AIDS epidemic]. 227 Jan 18

Effects of diethylstilbestrol (DES, 10 mg/d orally, Trial 1) or Synovex-S (SYN, 220 mg ear implant, Trial 2) on gain and N balance (g/d) were determined in steers that consumed 1.3, 2.7, 4.4 and 7.4 kg DM/d (Trial 1) and 1.3, 2.9, 4.3 and 6.6 kg DM/d (Trial 2). Each trial was a replicated 4 x 4 Latin square with four pairs of steers per trial (BW:322 kg, Trial 1; 278 kg Trial 2) and a control and growth promoter steer in each pair. Steers were fed a pelleted 75% concentrate diet containing 16.7% (DM basis). Each period consisted of 1 wk of intake adaptation, 5 wk of feeding and 1 wk in metabolism crates (2-d adjustment and 5-d collection). Steers were switched among DMI but not among promoter treatments. Intercept and slope, respectively, for the regression of BW gain (kg/d) on DMI (kg/d) were -.66 and .276 for control vs -.84 and .328 for DES steers and -.69 and .276 for control vs -.89 and .356 for SYN steers. Similar regression values for N balance (g/d) on DMI (kg/d) were -10.3 and 6.91 for control vs -17.2 and 9.10 for DES steers and -4.5 and 4.67 for control vs -7.6 and 5.85 for SYN steers. Across trials, slopes differed from zero (P less than .01), and promoter slopes differed from controls for gain (P less than .01) and N balance (P less than .10). During an extra period at the end of each trial, all steers were fed the high intake level for 6 wk, followed by N balance determinations the last 3 d of a 7-d fast.(ABSTRACT TRUNCATED AT 250 WORDS)
J Anim Sci 1990 Dec
PMID:Effects of intake level on metabolic response to estrogenic growth promoters in beef steers. 228 70

Analytical performance of the Boehringer Mannheim/Hitachi 717 system was evaluated in a multicenter study involving seven different laboratories. Fifty-five methods including end point chemistries, enzymes, ISE, TDM, DAU, and specific protein assays were assessed over a 7 month period. Methods on the analyzer exhibited excellent precision with CVs less than 2% for within run precision, and CVs less than 3% for between day precision for most analytes; linearity, which met or exceeded manufacturer's claims; minimal sample and reagent carryover, and no significant interference from hemolysis; icterus; and lipemia. Recovery of the assigned value for 10 analytes in SRM 909 was acceptable. Comparison of methods with other BM/Hitachi analyzers resulted in slopes close to unity (0.93-1.06); comparison to other clinical chemistry analyzers yielded slopes of 0.88-1.07. Excellent performance and diverse method applications make the BM/Hitachi 717 analyzer a suitable instrument for work station consolidation.
Clin Biochem 1990 Dec
PMID:A multicenter evaluation of the Boehringer Mannheim/Hitachi 717 system. 228 5

Over the past two decades the incidence of STDs has dramatically increased in the United States. Most patients with these infections present first to primary care physicians. All physicians must be familiar with the common STD syndromes and the indications for specific diagnostic tests in order to provide a comprehensive treatment plan. Primary prevention strategies based on patient education and secondary prevention through judicious use of screening tests in appropriate settings can also limit the morbidity associated with STDs.
Prim Care 1990 Dec
PMID:Sexually transmitted diseases. 229 Aug 78


<< Previous 1 2 3 4 5 6 7 8 9 10 Next >>